Amaç: Yenidoğanın geçici takipnesi (YDGT), yenidoğan yoğun bakımda çalışan hekimlerin en sık karşılaştığı solunumsal problem olup geç preterm bebeklerde görülme oranları, term bebeklere göre daha yüksektir. Trombositler, tam olarak bilinmeyen bir mekanizma ile akciğerde sıvı toplanmasını ve akciğer ödemini engeller. Trombositin fonksiyonu, sadece MPV (ortalama trombosit hacmi) ya da sadece trombosit sayısından ziyade, trombosit kitle indeksi ile daha doğru olarak değerlendirilebilir. Çalışmamızda, YDGT tanılı geç preterm bebeklerde sonunum destek ihtiyacı süresini ve diğer solunumsal sonlanımları ile PMI (trombosit kitle indeksi) başta olmak üzere trombosit belirteçlerinin ilişkisinin araştırılması planlanmıştır. Gereçler ve Yöntem: Bu retrospektif çalışmada, 1 Ağustos 2020-31Temmuz 2021 tarihleri arasında, YDGT tanısı ile Buca Seyfi Demirsoy Eğitim ve Araştırma Hastanesi yenidoğan yoğun bakım ünitesinde yatırılmış, takipnesi en az 12 saat sürmüş tüm geç preterm yenidoğanlara ait veriler hastane kayıtlarından incelendi. Bebeklerin trombosit belirteçleri, lökosit ve nötrofil değerleri ile solunum destek süreleri karşılaştırıldı. Ayrıca bu parametreler, gestasyonel haftalara göre olası farklılıklar açısından değerlendirildi. Bulgular: Çalışmaya 52 bebek dahil edildi. Gestasyonel hafta ortancası 35 hafta (34-366/7), ortalama doğum ağırlıkları 2647474 idi. Bebeklerin toplam solunum destek süreleri ya da >48 saat solunum desteği almaları ile trombosit sayısı, MPV, PMI, lökosit ve absolut nötrofil sayısı (ANS) ile ilişkili saptanmadı. Ancak 72 saatten fazla solunum desteği alan bebeklerde PMI değerlerinin daha düşük olduğu ve bunun da istatistiksel olarak anlamlı olduğu görüldü. Ayrıca MPV değerinin 35.gestasyon haftasında, ANS değerinin ise 36. gestasyon haftasında doğan bebeklerde anlamlı olarak yüksek olduğu görüldü. Sonuç: Çalışmamızda, trombosit belirteçlerinden, PMI’nın, YDGT tanılı geç preterm bebeklerin 72 saatten uzun süre solunum desteği almaları ile ilişkili olduğu, bu bebeklerin ortalama PMI değerlerinin daha düşük olduğu görülmüştür. Ancak benzer bir ilişki diğer trombosit belirteçleri ile solunum destek süresi arasında saptanmamıştır.

Background/Objectives: Retinopathy of prematurity (ROP) is a significant cause of childhood blindness, particularly among preterm infants. Patent ductus arteriosus (PDA) is commonly observed in neonates and may contribute to the development of ROP through increased oxygen delivery to the retina. However, the association between PDA and the severity of ROP remains unclear. This study aims to evaluate the relationship between PDA and the development of treatment-requiring ROP in preterm infants. Methods: A retrospective cohort study was conducted on preterm infants born between 2014 and 2020 at Izmir Private Medical Park Hospital. Infants with a birth weight of less than 2000 g and a gestational age of ≤36 + 6 weeks were included. Data on demographics, prematurity-related complications, PDA status, ROP severity, and treatment requirements were collected. Statistical analysis was performed using univariate and multivariate logistic regression models to identify predictors of ROP. Results: Of 516 infants, 328 did not have PDA, 117 had spontaneous PDA closure, and 71 required PDA treatment. Neonates requiring PDA treatment had significantly lower gestational age and birth weight, as well as longer respiratory support duration. PDA presence was associated with increased ROP incidence in univariate analysis (p < 0.001); however, it was not an independent predictor of treatment-requiring ROP in multivariate models. Significant predictors for treatment-requiring ROP included longer non-invasive ventilation duration (OR = 1.029) and total respiratory support (OR = 1.009). Conclusions: The findings of this study highlight the central role of respiratory morbidity in ROP pathogenesis and suggest that optimal respiratory management may be more critical for ROP prevention than PDA treatment alone.

Objective: Early-onset hypocalcemia (EOH) is a common metabolic disorder in neonates, which occurs during the first three days of life. The purpose of the study is to define the hypocalcemia characteristics, its clinical presentations, laboratory findings, and treatment for early-onset hypocalcemia in newborns. Method: This is a cross sectional study obtaining the patient’s data retrospectively from the Neonatal Intensive Care Unit at İzmir Buca Seyfi Demirsoy Training and Research Hospital. Fifty-one neonates born with ≥ 37 weeks of gestation who were diagnosed with hypocalcemia within the first three days of life between 2022-2024 were included in the study. The study analyzed demographic characteristics, laboratory values, timing and severity of hypocalcemia, treatment methods, and discharge details. Results: The study found no significant association between 25-OH vitamin D levels and birth weight or gestational age in neonates with EOH. Neonatal hypocalcemia onset on the 2nd and 3rd days of life showed higher initial calcium levels, suggesting early calcium levels may play a role. No significant association was found between 25-OH vitamin D levels and serum calcium, ionized calcium, or albumin levels, and hospitalization length. The use of calcium or vitamin D supplements did not influence 25-OH vitamin D levels or hypocalcemia outcomes. Conclusion: Gestational age and initial calcium levels are predictive of the timing and severity of EOH. However, 25-OH vitamin D levels were not significantly associated with birth weight, blood calcium, ionized calcium, or albumin levels in this population. These findings suggest that other factors influencing vitamin D metabolism in neonates with EOH require further investigation.

Backround: Neonatal pulmonary hypertension(PHT) is a significant cause of morbidity and mortality in newborns. Early diagnosis and treatment of pulmonary hypertension are critical for preventing long-term respiratory and cardiovascular complications. The aim of this study is to contribute to the literature by investigating the differences between neonates with PHT who receive medical treatment and those who do not, the relationship between echocardiographic measurements and the initiation of treatment, and the differences between preterm and term neonates. Methods: In this retrospective cohort study, 75 neonates diagnosed with pulmonary hypertension and treated in the neonatal intensive care unit were retrospectively analyzed. The diagnosis of PHT was established by echocardiography with estimation of pulmonary artery pressure via tricuspid regurgitation jet velocity measurement. Right Ventricular Systolic Pressure(RVSP) measurements were recorded as RVSP1 for the first three days, RVSP2 between days 3-7, and RVSP3 after 7 days. For statistical evaluation, patients were divided into two groups based on whether they received medical treatment for PHT and were compared. The group receiving PHT treatment was further divided into preterm (<37 weeks) and term (≥37 weeks) neonates and compared. Results: Among the 7578 patients in the neonatal intensive care unit, 75 (0.99%) were diagnosed with pulmonary hypertension. 47 of these patients received PHT treatment. The treatment group had a greater gestational age and higher birth weight. There was no significant difference in laboratory parameters between the groups receiving and not receiving PHT treatment. However, in the group not receiving PHT, patients with low RVSP measurements had lower CRP values. The duration of invasive and non-invasive mechanical ventilation was longer in the group receiving PHT treatment. RVSP2 and RVSP3 values were higher in the treatment group. The RVSP1-2 difference was significant in the treatment group. Conlusions: In echocardiographic evaluation, persistently elevated pulmonary artery pressure measured by tricuspid regurgitation jet velocity after the third day is strongly associated with PHT treatment. Neonates with RVSP lower than 40 mmHg and negative CRP did not require pulmonary hypertension treatment.