As bacteria transition from exponential to stationary phase they change greatly in size, morphology, growth and expression-profiles. These responses also vary between individual cells, but it has proven difficult to track cell lineages along the growth curve to determine the progression of events or correlations between how individual cells enter and exit dormancy. We developed a platform for tracking >10 ⁵ parallel cell lineages in dense and changing cultures, independently validating that the imaged cells closely track batch populations. Initial applications show that for both Escherichia coli and Bacillus subtilis , growth changes from an ‘adder’ mode in exponential phase to mixed ‘adders-timers’ entering stationary phase, and then a near-perfect ‘sizer’ upon exit – creating broadly distributed cell sizes in stationary phase but rapidly returning to narrowly distributed sizes upon exit. Furthermore, cells that undergo more divisions entering stationary phase suffer reduced survival after long periods of dormancy but are the only cells observed that persist against antibiotics.

Günümüzde ölümler tipik olarak kademeli fiziksel ve işlevsel bir düşüş döneminden sonra ileri bir yaşta meydana gelmektedir. Bu durum yaşamın son aşamasındaki hastalara yönelik yüksek kaliteli bakımı, XXI. yüzyılın sağlık hizmetlerinin temel zorluklarından birisi hâline getirmektedir. Biyomedikal araştırmalardaki ilerlemeler ve biyoetikte yeni disiplinlerin kurulması yaşam sonu bakımı, ötanazi ve hekim yardımlı intihar konusunda güncel tartışmaları beraberinde getirmektedir. Geçmişten günümüze gelen tartışmalar hâlâ güncelliğini korurken, ötanazi ve hekim yardımlı intihar dünya çapında giderek daha fazla yasallaşmaktadır. Bu tür düzenlemelerin temel amaçları; uygulamaları netliğe kavuşturmak, hekimlere yasal zemini açık bir şekilde sunmak ve hastaları korumaktır. Buna rağmen ölümde tıbbi yardım konusu, paradoksik unsurlar içeren çok boyutlu ciddi tartışmaları gündeme getirerek kamunun dikkatini çekmektedir. Bu uygulamaların evrimi ile ilgili tarihsel yönlerin ve ilgili literatürün araştırılması geçmişten günümüze gelen tartışmaları aydınlatabilir. Bu terimlerin evrimi ve olgularla biçimlenen yasal düzenlemeler, multidisipliner bir yaklaşımın gerekliliğini vurgulamaktadır. Metinde uygulamaların lehindeki ve aleyhindeki yaygın argümanlar literatür verileri ışığında sunulmaktadır. Ayrıca ölümde tıbbi yardım konusunu adli boyutları ve uygulanma biçimleriyle karşılaştırmak klinisyenlere farklı görüşler sunabilir. Derleme ötanazi ve hekim yardımlı intihar uygulamaları sürecinde yer alan ve genellikle ihmal edilen hekimin profesyonel yükümlülükleriyle çelişen gerilimini ortaya koymaktadır. Gözden geçirme, ötanazi ve hekim yardımlı intihar talebinde bulunan hastaların değerlendirilmesinde rol alan psikiyatristlerin ikilem içeren görüşlerinin tartışılmasıyla sona ermektedir.

Stressful or traumatic life events can lead to emergence of mood episodes. Events such as migration, relocation, job loss, bankruptcy, economic loss, divorce, natural disasters, accidental injury, or the loss of a loved one can trigger the first episode of bipolar disorder. After such life events, symptoms of depressive episodes often appear. Funeral mania, on the other hand, is defined as the emergence of manic episodes following the death of a close family member. Information on funeral mania, which occurs shortly after the loss of a loved one, is limited with a few case reports. In this study, a 26-year-old female patient who presented with the symptoms of a manic episode for the first time after her father’s death and who had no previous psychiatric disease or treatment history was presented in the light of findings in the literature. It is noteworthy that the patient, who was followed up with the diagnosis of bipolar disorder (mania period) according to DSM-5 diagnostic criteria, had a temporal closeness between her mood symptoms and her father’s death, and had not developed such a reaction to previous traumatic life events. Therefore, the diagnosis was evaluated as funeral mania. It should be kept in mind that, although rare, symptoms of mania can be seen among possible grief reactions

Emerging evidence suggests that individual chronotypes may influence eating behavior through different dimensions of hedonic processing. This study aimed to examine the mediating role of anticipatory (“wanting”) and consummatory (“liking”) pleasure in the relationship between morningness chronotype and emotional eating behavior within a framework informed by the wanting-liking balance model. A cross-sectional design was used with 236 medical students aged 18–30 years. Participants completed the Morningness–Eveningness Questionnaire (MEQ) to determine chronotype, the Temporal Experience of Pleasure Scale (TEPS) with consummatory (TEPS-CPF) and anticipatory (TEPS-CAPF) subscales, and the Dutch Eating Behavior Questionnaire (DEBQ), which assesses restrained (RE), emotional (EE), and external eating (ExE). Based on MEQ scores, 236 students (66.5% female; median age = 21 years) were classified as evening (24.6%), morning (17.8%), or neither type (57.6%). Chronotype groups differed only in daily smoking, which was more common among evening types (p = .003). SEM showed direct effects of MEQ on DEBQ-RE (β = .31, p < .01) and DEBQ-ExE (β = –.21, p < .01), while TEPS-CAPF partially mediated these associations (DEBQ-RE: β = –.05, p = .026; DEBQ-ExE: β = .08, p = .002). These findings highlight the complex, multidimensional role of hedonic pleasure in shaping eating behaviors and suggest that chronotype-related differences in reward processing may contribute to individual variability in eating regulation. The study supports a transdiagnostic perspective of hedonic functioning and highlights the need to assess both the “wanting” and “liking” dimensions in the context of eating behavior and chronobiology.