Lithium-ion cells are increasingly being used as central power storage systems for modern applications, i.e., e-bikes, electric vehicles (EVs), satellites, and spacecraft, and they face significant and constant vibrations. This review examines how these vibrations affect the batteries’ mechanical, thermal, and electrical properties. Vibrations can cause structural issues, such as the separation of electrodes and the deformation of separators. These problems raise internal resistance and lead to localized heat generation. As a result, thermal management becomes more complicated, battery aging accelerates, and safety risks arise, including short circuits and thermal runaways. To tackle these challenges, we need more realistic testing protocols that consider the combined effects of vibrations, temperature, and mechanical stress. Improving thermal management systems (TMSs) using advanced cooling techniques and materials, e.g., phase change solutions, can help to alleviate these problems. It is also essential to design batteries with vibration-resistant materials and enhanced structural integrity to boost their durability. Moreover, vibrations play a significant role in various degradation mechanisms, including dendrite formation, self-discharge, and lithium plating, all of which can reduce battery capacity and lifespan. Our current research builds on these insights using a multiscale physics-based modeling approach to investigate how vibrations interact with thermal behavior and contribute to battery degradation. By combining computational models with experimental data, we aim to develop strategies and tools to enhance lithium-ion batteries’ safety, reliability, and longevity in challenging environments.