Critical mineral resources (CMRs) are essential for emerging high-tech industries and are geopolitically significant, prompting countries to pursue resource exploration and development. Tibetan geothermal systems, recognized for their CMR potential, have not yet been systematically evaluated. This study presents a comprehensive investigation of the spatial distributions, resource flux, reserves, and resource effects of CMRs, integrating and analyzing hydrochemical and discharge flow rate data. Geochemical findings reveal significant enrichment of lithium (Li), rubidium (Rb), cesium (Cs), and boron (B) in the spring waters and sediments, primarily located along the Yarlung Zangbo suture and north–south rift zones. Resource flux estimates include approximately 246 tons of Li, 54 tons of Rb, 233 tons of Cs, and 2747 tons of B per year, underscoring the mineral potential of the geothermal spring waters. Additionally, over 40,000 tons of Cs reserves are preserved in siliceous sinters in Tagejia, Gulu, and Semi. The Tibetan geothermal systems thus demonstrate considerable potential for CMRs, especially Cs, through stable discharge and widespread distribution, also serving as indicators for endogenous mineral exploration and providing potential sources for lithium in exogenous salt lakes. This study evaluates the CMR potential of the Tibetan geothermal systems, advancing CMR exploration while contributing to the future security of CMR supplies.