Understanding brain oxygen metabolism is crucial for evaluating overall health, par-ticularly in high-stress medical situations such as cardiac arrest and cardiopulmonary resuscitation (CPR). This study focuses on two key indicators of brain oxygen metabo-lism: the cerebral metabolic rate of oxygen (CMRO2) and the oxidation state of redox cytochrome c oxidase (rCCO). Using advanced techniques like hyperspectral near-infrared spectroscopy (hNIRS) and laser doppler flowmetry (LDF), we have con-ducted a comprehensive analysis of their relationship in pigs during and after cardiac arrest and CPR. We investigated both the entire duration of these experiments and specific time intervals, providing a detailed view of how these metrics interact. The data reveals non-linear relationship between rCCO and CMRO2. Our findings contribute to a deeper understanding of how the brain manages oxygen during critical episodes, po-tentially guiding future interventions in neurological care and improving outcomes in emergency medical settings.