The densification of yellow poplar (Liriodendron tulipifera) has emerged as a critical area of research, driven by its desirable properties and broad potential applications. This study investigated the effects of four densification parameters using a 2⁴ full factorial design to evaluate their impact on physical and mechanical properties. Analysis of variance (ANOVA) and Pareto analyses identified the compression ratio as the most influential factor, significantly affecting bending strength, compression strength, hardness, and spring-back behavior. Pressing temperature was the second most significant factor, with higher levels positively impacting mechanical properties. However, increasing the pre-steaming treatment duration from 30 to 60 min at 130 °C had a detrimental effect on strength and spring-back performance, particularly at a 50% compression ratio. Pressing time showed no significant effect on strength properties but contributed positively to hardness and spring-back behavior at higher levels. Several significant factor interactions were observed, further influencing the outcomes. Differences in density profiles were notable across compression ratios, with higher ratios producing more uniform distributions. Under optimal parameters, densification increased compression strength by 117%, bending strength by 60%, and hardness by 154% compared to undensified control samples, demonstrating the potential of densified yellow poplar (Liriodendron tulipifera) for high-performance applications.