Stephan Orzada

Dr. Stephan Orzada

orcid

Research Focus & Metrics

Academic Career Length

22Years (2005-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 June 2011 in NeuroImage
Verified
Journal Article
Closed access
PKPeter J. Koopmans
Peter J. Koopmans
MBMarkus Barth
Markus Barth
SOStephan Orzada
Stephan Orzada
DNDavid G. Norris
David G. Norris

22 June 2010 in Magnetic Resonance in Medicine
Verified
Journal Article
Open access
PDF file
SOStephan Orzada
Stephan Orzada
SMStefan Maderwald
Stefan Maderwald
BPBenedikt A Poser
Benedikt A Poser
ABAndreas K. Bitz
Andreas K. Bitz
HQHarald H. Quick
Harald H. Quick
MLMark E. Ladd
Mark E. Ladd
As the field strength and, therefore, the operational frequency in MRI is increased, the wavelength approaches the size of the human head/body, resulting in wave effects, which cause signal decreases and dropouts. Several multichannel approaches have been proposed to try to tackle these problems, including RF shimming, where each element in an array is driven by its own amplifier and modulated with a certain (constant) amplitude and phase relative to the other elements, and Transmit SENSE, where spatially tailored RF pulses are used. In this article, a relatively inexpensive and easy to use imaging scheme for 7 Tesla imaging is proposed to mitigate signal voids due to B field inhomogeneity. Two time‐interleaved images are acquired using a different excitation mode for each. By forming virtual receive elements, both images are reconstructed together using GRAPPA to achieve a more homogeneous image, with only small SNR and SAR penalty in head and body imaging at 7 Tesla. Magn Reson Med, 2010.

1 November 2009 in Investigative Radiology
Verified
Journal Article
Closed access
OKOliver Kraff
Oliver Kraff
ABAndreas K. Bitz
Andreas K. Bitz
SKStefan Kruszona
Stefan Kruszona
SOStephan Orzada
Stephan Orzada
LSLena C. Schaefer
Lena C. Schaefer
HQHarald H. Quick
Harald H. Quick
To develop a transmit/receive radiofrequency (RF) array for MR imaging of the human spine at 7 T. The prototype is characterized in simulations and bench measurements, and the feasibility of high-resolution spinal cord imaging at 7 T is demonstrated in in vivo images of volunteers. The RF phased array consists of 8 overlapping surface loop coils with a dimension of 12 cm x 12 cm each. Bench measurements were obtained with a phantom made of body-simulating liquid and assessed with a network analyzer. For safety validation, numerical computations of the RF field distribution and the corresponding specific absorption rate were performed on the basis of 3 different human body models. In vivo images of 3 volunteers (2 with a documented scoliosis) were acquired using a 3D-FLASH sequence with a high spatial resolution of 0.57 mm isotropic. The 7 T transmit/receive RF coil could be easily integrated into the patient table for examinations of the cervicothoracic or thoracolumbosacral spine. Comparable results were found for all 3 numerical calculations using different human body models. Measurements of the g-factor indicated good image quality for parallel imaging acceleration factors up to 2.7 along the head-feet direction, which could be validated in the in vivo images. The in vivo images demonstrated very fine anatomic features such as the longitudinal ligaments or the venous drainage through the vertebral bodies. A largely homogeneous excitation over an extensive field-of-view of 40 cm could be obtained. These early results indicate that a multichannel transmit/receive phased array RF coil can be used for in vivo spine imaging at 7 T, thereby rendering high-resolution spine imaging a promising new application in 7 T clinical research.

12 September 2019 in PLOS ONE
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Journal Article
Open access
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SOStephan Orzada
Stephan Orzada
KSKlaus Solbach
Klaus Solbach
MGMarcel Gratz
Marcel Gratz
SBSascha Brunheim
Sascha Brunheim
TFThomas M Fiedler
Thomas M Fiedler
MLMark E Ladd
Mark E Ladd
A 32-channel parallel transmit (pTx) add-on for 7 Tesla whole-body imaging is presented. First results are shown for phantom and in-vivo imaging. The add-on system consists of a large number of hardware components, including modulators, amplifiers, SAR supervision, peripheral devices, a control computer, and an integrated 32-channel transmit/receive body array. B1+ maps in a phantom as well as B1+ maps and structural images in large volunteers are acquired to demonstrate the functionality of the system. EM simulations are used to ensure safe operation. Good agreement between simulation and experiment is shown. Phantom and in-vivo acquisitions show a field of view of up to 50 cm in z-direction. Selective excitation with 100 kHz sampling rate is possible. The add-on system does not affect the quality of the original single-channel system. The presented 32-channel parallel transmit system shows promising performance for ultra-high field whole-body imaging.

19 August 2011 in Magnetic Resonance in Medicine
Verified
Journal Article
Open access
PDF file
SOStephan Orzada
Stephan Orzada
SMS. Maderwald
S. Maderwald
BPBenedikt A Poser
Benedikt A Poser
SJS. Johst
S. Johst
SKS. Kannengiesser
S. Kannengiesser
ABA. K. Bitz
A. K. Bitz
As the magnetic field strength and therefore the operational frequency in MRI are increased, the radiofrequency wavelength approaches the size of the human head/body, resulting in wave effects which cause signal decreases and dropouts. Especially, whole‐body imaging at 7 T and higher is therefore challenging. Recently, an acquisition scheme called time‐interleaved acquisition of modes has been proposed to tackle the inhomogeneity problems in high‐field MRI. The basic premise is to excite two (or more) different B modes using static radiofrequency shimming in an interleaved acquisition, where the complementary radiofrequency patterns of the two modes can be exploited to improve overall signal homogeneity. In this work, the impact of time‐interleaved acquisition of mode on image contrast as well as on time‐averaged specific absorption rate is addressed in detail. Time‐interleaved acquisition of mode is superior in B homogeneity compared with conventional radiofrequency shimming while being highly specific absorption rate efficient. Time‐interleaved acquisition of modes can enable almost homogeneous high‐field imaging throughout the entire field of view in PD, T2, and T2*‐weighted imaging and, if a specified homogeneity criterion is met, in T1‐weighted imaging as well. Magn Reson Med, 2011.

24 June 2013 in Magnetic Resonance in Medicine
Verified
Journal Article
Open access
PDF file
MMMarnix C. Maas
Marnix C. Maas
EVEline K. Vos
Eline K. Vos
MLMiriam W. Lagemaat
Miriam W. Lagemaat
ABAndreas K. Bitz
Andreas K. Bitz
SOStephan Orzada
Stephan Orzada
TSTom W. J. Scheenen
Tom W. J. Scheenen
Purpose To demonstrate that high quality T2-weighted (T2w) turbo spin-echo (TSE) imaging of the complete prostate can be achieved routinely and within safety limits at 7 T, using an external transceive body array coil only. Methods Nine healthy volunteers and 12 prostate cancer patients were scanned on a 7 T whole-body system. Preparation consisted of B0 and radiofrequency shimming and localized flip angle calibration. T1 and T2 relaxation times were measured and used to define the T2w-TSE protocol. T2w imaging was performed using a TSE sequence (pulse repetition time/echo time 3000–3640/71 ms) with prolonged excitation and refocusing pulses to reduce specific absorption rate. Results High quality T2w TSE imaging was performed in less than 2 min in all subjects. Tumors of patients with gold-standard tumor localization (MR-guided biopsy or prostatectomy) were well visualized on 7 T imaging (n = 3). The number of consecutive slices achievable within a 10-g averaged specific absorption rate limit of 10 W/kg was ≥28 in all subjects, sufficient for full prostate coverage with 3-mm slices in at least one direction. Conclusion High quality T2w TSE prostate imaging can be performed routinely and within specific absorption rate limits at 7 T with an external transceive body array. Magn Reson Med 71:1711–1719, 2014.