In-space manufacturing represents a transformative frontier in space exploration and industrial production, offering the potential to revolutionize how goods are produced and resources are utilized beyond Earth. This paper explores the multifaceted aspects of in-space manufacturing, including its evolution, technologies, challenges, and future prospects, while also addressing ethical and legal dimensions critical to its development. Beginning with an overview of its significance and historical context, this paper underscores key concepts such as resource optimization and the reduction of launch costs. It examines terrestrial and space-based manufacturing processes, emphasizing additive manufacturing, advanced materials processing, autonomous robotic systems, and biomanufacturing for pharmaceuticals. Unique challenges posed by the space environment, such as microgravity, vacuum conditions, and radiation exposure, are analyzed alongside issues related to supply chains, quality assurance, and energy management. Drawing from case studies, including missions aboard the International Space Station, this paper evaluates the lessons learned over six decades of innovation in in-space manufacturing. It further explores the potential for large-scale production to support deep-space missions and assesses the commercial and economic feasibility of these technologies. This paper also delves into the policy, legal, and ethical considerations to address as space-based manufacturing becomes integral to future space exploration and the global space economy. Ultimately, this work provides a comprehensive roadmap for advancing in-space manufacturing technologies and integrating them into humanity’s pursuit of sustainable and scalable space exploration.

The global transition from internal combustion engines (ICEs) to hybrid (HEVs) and electric vehicles (EVs) is fundamentally reshaping lubricant design requirements, driven by evolving thermal demands, electrical constraints, and material compatibility challenges. Conventional ICE lubricants are primarily formulated to withstand high operating temperatures, mechanical stresses, and combustion-derived contaminants through established additive chemistries such as zinc dialkyldithiophosphate (ZDDP), with thermal stability and wear protection as dominant considerations. In contrast, HEV lubricants must accommodate frequent start–stop operation, pronounced thermal cycling, and fuel dilution while maintaining performance across coupled mechanical and electrical subsystems. EV lubricants represent a paradigm shift, where requirements extend beyond tribological protection to include electrical insulation and conductivity control, thermal management of electric motors and battery systems, and compatibility with copper windings, polymers, elastomers, and advanced coatings, alongside mitigation of noise, vibration, and harshness (NVH). This review critically examines lubricant behavior, formulation strategies, and performance requirements across ICE, HEV, and EV powertrains, with specific emphasis on heat transfer, electrical performance, and lubricant–material interactions, covering mineral, synthetic, and bio-based fluids. Additionally, regulatory drivers, sustainability considerations, and emerging innovations such as nano-additives, multifunctional and smart lubricants, and AI-assisted formulation are discussed. By integrating recent research into industrial practice, this work highlights the increasingly interdisciplinary role of tribology in enabling efficient, durable, and sustainable mobility for next-generation automotive systems.