Head and neck cancers (HNCs) are often diagnosed late, leading to poor prognosis. Chronic inflammation, particularly periodontitis, has been linked to carcinogenesis, but systemic inflammatory markers remain underexplored. This study was the first to examine whether elevated C-reactive protein (CRP) can serve as a cost-effective adjunct in HNC risk assessment, alongside oral health indicators. A retrospective cohort study analysed 23,742 hospital records (4833 patients, 2015–2022) from the University Hospital of Debrecen. HNC cases were identified using ICD-10 codes, with CRP and periodontitis as key predictors. Kaplan–Meier survival analysis, log-rank tests, and Weibull regression were used to assess risk, with model performance evaluated via AIC/BIC and ROC curves. Periodontitis was significantly associated with HNC (HR 5.99 [1.96–18.30]), while elevated CRP (>15 mg/L) independently increased risk (HR 4.16 [1.45–12.00]). Females had a significantly lower risk than males (HR 0.06 [0.01–0.50]). CRP may serve as a cost-effective, easily accessible biomarker for early HNC detection when combined with oral health screening. Integrating systemic inflammation markers into HNC risk assessment models could potentially improve early diagnosis in high-risk populations.

Az A- és B-típusú haemophilia az egyik leggyakrabban előforduló örökletes vérzési rendellenesség. A veleszületett vérzékenységben szenvedők azonban a népesség kis létszámú csoportját képezik. A betegek kezelése ezért kihívást jelenthet a fogorvosok számára, mivel sokuknak nincs tapasztalata haemophiliás páciensekkel. Ennek következményeként a betegek fogászati ellátása gyakran háttérbe szorul. A vérzékeny páciensek valóban fokozott rizikócsoportba tartoznak a fogorvosi ellátás területén, azonban a legtöbb rutin-, nem sebészeti beavatkozás elvégezhető általános fogászati praxisban is hematológussal történt konzultációt követően, a szakmai protokoll betartása mellett. Átfogó magyar nyelvű ajánlást a veleszületett vérzékeny betegek fogorvosi ellátásának lehetőségeiről nem publikáltak. A közlemény célja, hogy áttekintse és összefoglalja a fogorvosi ellátás irodalmát a haemophiliás betegeket érintően minden fogászati szakterület vonatkozásában. Az irodalmi áttekintés hasznos összefoglalóként szolgálhat a fogorvosok számára, melynek segítségével magabiztosabban kezelhetik pácienseiket, megteremtve a feltételeket a haemophiliás betegek fogászati ellátásának területén tapasztalt nehézségek leküzdéséhez. A közlemény a haemophiliás betegek gondozásában részt vevő szakemberek számára is értékes összefoglalóként szolgálhat a fogorvosi beavatkozásokról és a haemophiliás betegek fogorvosi ellátásának lehetőségeiről. Orv Hetil. 2022; 163(24): 943–951.

Introduction: Patients with haemophilia (PWH) often have difficulty accessing dental services.Aim: To determine the accessibility of dental care for PWH and to examine their perceptions of how coronavirus type‐2 (CoV‐2) disease (COVID‐19) has affected their ability to access dental treatments following the pandemic.Methods: The questionnaire survey was conducted between July 2022 and December 2022 at haemophilia treatment centres in Hungary. Variables with statistical significance (Pearson's Chi‐squared test; p < .05) were included in logistic regression analyses. Least absolute shrinkage and selection operator (LASSO) regression was used as a machine learning technique to identify the most predictive variables.Results: Twenty‐one percent of the sixty‐eight participants reported that they had been refused dental treatment, mainly in primary care (86%). Dental refusal was influenced by infectious disease (OR: 4.48, CI: 1.14–17.69) and previous dental bleeding complications (OR: 4.23, CI: 1.10–16.27). There was correlation between dental visits and having a permanent dentist or receiving oral hygiene advice (OR: 9.95, CI: 2.86–34.62 and OR: 3.84, CI: 1.09–13.58). Participation in an oral hygiene consultation increased patients’ satisfaction with their dental care (OR: 6.28, 95% CI: .71–55.88). Twenty‐eight percent of patients had experienced difficulties since the start of the COVID‐19, but 84% had visited their dentist at least once between 2021 and 2022 (p = .002). Nevertheless, 16% of respondents went for only the most necessary treatments due to pandemic.Conclusion: Refusal of dental care was high among participants, especially in primary care. The COVID‐19 pandemic has exaggerated the difficulties of PWH in accessing dental treatment.Highlights: Patients with haemophilia (PWH) have difficulty accessing dental care, and the coronavirus type 2 (CoV‐2) disease pandemic (COVID‐19) has created a new barrier. The study revealed a high prevalence of dental care refusal (21%), particularly in primary care (86%). This 2022 survey found that 28% of patients experienced difficulties since the pandemic started and 16% only sought necessary treatments.