Bekzat Tynybekov

Prof. Dr. Bekzat Tynybekov


Research Focus & Metrics

Academic Career Length

6Years (2021-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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7 October 2022 in Cancer Cell International
Verified
Journal Article
Open access
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PDPraveen Dhyani
Praveen Dhyani
PSPriyanka Sati
Priyanka Sati
ESEshita Sharma
Eshita Sharma
DADharam Chand Attri
Dharam Chand Attri
ABAmit Bahukhandi
Amit Bahukhandi
William C. ChoWilliam C. Cho
William C. Cho
Plants-based natural compounds are well-identified and recognized chemoprotective agents that can be used for primary and secondary cancer prevention, as they have proven efficacy and fewer side effects. In today's scenario, when cancer cases rapidly increase in developed and developing countries, the anti-cancerous plant-based compounds become highly imperative. Among others, the Asteraceae (Compositae) family's plants are rich in sesquiterpenoid lactones, a subclass of terpenoids with wide structural diversity, and offer unique anti-cancerous effects. These plants are utilized in folk medicine against numerous diseases worldwide. However, these plants are now a part of the modern medical system, with their sesquiterpenoid lactones researched extensively to find more effective and efficient cancer drug regimens. Given the evolving importance of sesquiterpenoid lactones for cancer research, this review comprehensively covers different domains in a spectrum of sesquiterpenoid lactones viz (i) Guaianolides (ii) Pseudoguaianolide (iii) Eudesmanolide (iv) Melampodinin A and (v) Germacrene, from important plants such as Cynara scolymus (globe artichoke), Arnica montana (wolf weeds), Spilanthes acmella, Taraxacum officinale, Melampodium, Solidago spp. The review, therefore, envisages being a helpful resource for the growth of plant-based anti-cancerous drug development.

21 February 2025 in International Journal of Biological Macromolecules
Verified
Journal Article
Open access
YCYan Cao
Yan Cao
JSJingtao Su
Jingtao Su
YXYongshuang Xiao
Yongshuang Xiao
JRJuanna Ren
Juanna Ren
HAHassan Algadi
Hassan Algadi
YMYonggang Min
Yonggang Min
With the growth of energy demand and the depletion of fossil fuels, the need for new energy storage materials is urgent. Phase change materials (PCMs) play a key role in thermal energy storage and can effectively balance energy supply and demand. There is increasing interest in biological macromolecules derived from nature, which have good biocompatibility, non-toxicity, easy biodegradability and tunable mechanical properties. The integration of PCMs with biological macromolecules is highly promising as it combines the advantages of both to meet the requirements of eco-friendly energy solutions. This paper reviews the recent research on this topic, covering biomass source selection, the functionalization process, various phase change composites based on biological macromolecules and biomass, as well as biomass-derived PCMs. Furthermore, the paper explores their performance across various application domains, including degradable materials, solar energy storage and utilization, building energy conservation, multifunctional wearable devices, electromagnetic interference shielding, flame retardant materials, and thermally stimulated drug delivery. Finally, the paper outlines prospective avenues for future research.

9 October 2023 in Chemico-Biological Interactions
Verified
Journal Article
Closed access
Parteek PrasherParteek Prasher
Parteek Prasher
RFRabab Fatima
Rabab Fatima
MSMousmee Sharma
Mousmee Sharma
BTBekzat Tynybekov
Bekzat Tynybekov
AAAsma Alshahrani
Asma Alshahrani
Daniela CalinaDaniela Calina
Daniela Calina

8 August 2022 in BioMed Research International
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Journal Article
Open access
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SASaule Dzhumagalievna Atabayeva
Saule Dzhumagalievna Atabayeva
ARAgilan B. Rakhymgozhina
Agilan B. Rakhymgozhina
АНАкмарал Нурмаханова
Акмарал Нурмаханова
SKSaule Kenzhebayeva
Saule Kenzhebayeva
BUBakdaulet Usenbekov
Bakdaulet Usenbekov
AAAigul K. Amirova
Aigul K. Amirova
Due to the environment pollution by cadmium (Cd) near industrial metallurgic factories and the widespread use of phosphorus fertilizers, the problem of toxic Cd effect on plants is well discussed by many authors, but the phytotoxicity of Cd under iron (Fe) deficiency stress has not been sufficiently studied. The aim of the work was to study comprehensively the effect of Cd under Fe deficiency conditions on physiological, biochemical, and anatomical parameters of rice varieties, to identify varietal differences in plant response to the effect of double stress. Relative resistance and sensitivity to the joint effect of Cd and Fe deficiency stress rice varieties have been identified. Double stress decreased a linear growth and biomass accumulation of roots and shoots (by 36‐50% and 33‐46% and 32‐56% and 32‐48%, accordingly), content of photosynthetic pigments (Chla, Chlb, and carotenoids by 36‐51%, 32‐47%, and 64‐78%, accordingly), and relative water content (by 18‐26%). Proline content increased by 28‐103% in all rice varieties, but to a lesser extent in sensitive varieties. The thickness of the lower and upper epidermis and the diameter of vascular bundles of leaves decreased by 18‐50%, 46‐60%, and 13‐48%, accordingly. The thickness of the root endodermis and exodermis and diameter of the central cylinder mainly decreased. The thickness of the exodermis increased slightly by 7%, and the diameter of the central cylinder remained at the control level in resistant Madina variety while in sensitive Chapsari variety, these indicators decreased significantly by 50 and 45%, accordingly. Thus, the aggravation of adverse effect of Cd under Fe deficiency conditions and the varietal specificity of plants’ response to double stress were shown. It creates the need for further study of these rice varieties using Fe to identify mechanisms for reducing the toxic effect of Cd on plants as well as the study of Fe and Cd transporter genes at the molecular level.

1 September 2023 in Journal of Ecological Engineering
Verified
Journal Article
Open access
АНАкмарал Нурмаханова
Акмарал Нурмаханова
NINazerke Ibisheva
Nazerke Ibisheva
NKNatalia Kurbatova
Natalia Kurbatova
SASaule Dzhumagalievna Atabayeva
Saule Dzhumagalievna Atabayeva
ASAinur Seilkhan
Ainur Seilkhan
GSGulbanu Sadyrova
Gulbanu Sadyrova
The manuscript presents the results of morpho-anatomical structure of vegetative organs of Salvia aethiopis L. S.aethiopis L. is a promising medicinal plant of flora of Kazakhstan, which is able to grow under certain soil and climatic conditions. According to its anatomical and morphological...

1 January 2022 in Journal of Ecological Engineering
Verified
Journal Article
Open access
PDF file
ACAssel Childibayeva
Assel Childibayeva
AAAbibulla Ametov
Abibulla Ametov
NKNatalia Vladimirovna Kurbatova
Natalia Vladimirovna Kurbatova
AAAigul Akhmetova
Aigul Akhmetova
BTBekzat Tynybekov
Bekzat Tynybekov
GMGulzhanat Amangeldykyzy Mukanova
Gulzhanat Amangeldykyzy Mukanova
The article provides brief geobotanical characteristics of plant communities of three populations of R. iliensis Chrshan. found in the floodplains of the Ili and Sharyn rivers, and also presents the morpho-anatomical structure of vegetative organs (stem and leaf) of the species under study. R....