Large language models (LLMs) are rapidly advancing medical artificial intelligence, offering revolutionary changes in health care. These models excel in natural language processing (NLP), enhancing clinical support, diagnosis, treatment, and medical research. Breakthroughs, like GPT-4 and BERT (Bidirectional Encoder Representations from Transformer), demonstrate LLMs’ evolution through improved computing power and data. However, their high hardware requirements are being addressed through technological advancements. LLMs are unique in processing multimodal data, thereby improving emergency, elder care, and digital medical procedures. Challenges include ensuring their empirical reliability, addressing ethical and societal implications, especially data privacy, and mitigating biases while maintaining privacy and accountability. The paper emphasizes the need for human-centric, bias-free LLMs for personalized medicine and advocates for equitable development and access. LLMs hold promise for transformative impacts in health care.

Deep neural networks suffer from catastrophic forgetting when continually learning new concepts. In this paper, we analyze this problem from a data imbalance point of view. We argue that the imbalance between old task and new task data contributes to forgetting of the old tasks. Moreover, the increasing imbalance ratio during incremental learning further aggravates the problem. To address the dynamic imbalance issue, we propose Uniform Prototype Contrastive Learning (UPCL), where uniform and compact features are learned. Specifically, we generate a set of non-learnable uniform prototypes before each task starts. Then we assign these uniform prototypes to each class and guide the feature learning through prototype contrastive learning. We also dynamically adjust the relative margin between old and new classes so that the feature distribution will be maintained balanced and compact. Finally, we demonstrate through extensive experiments that the proposed method achieves state-of-the-art performance on several benchmark including CIFAR-100, ImageNet-100, TinyImageNet, Food-101, and CUB-200. Experimental results show that our approach not only effectively addresses the issue of imbalanced old data in memory but also tackles the problem of imbalanced new data distributions.

Self-play methods have achieved remarkable success in two-player zero-sum games, attaining superhuman performance in many complex game domains. Parallelizing learners is a feasible approach to handle complex games. However, parallelizing learners often leads to the suboptimal exploitation of computational resources, resulting in inefficiencies. This paper introduces the Mixed Hierarchical Oracle (MHO), which is designed to enhance training efficiency and performance in complex two-player zero-sum games. MHO efficiently leverages interaction data among parallelized solvers during the Parallelized Oracle (PO) process, while employing Model Soups (MS) to consolidate fragmented computational resources and Hierarchical Exploration (HE) to balance exploration and exploitation. These carefully designed enhancements for parallelized systems significantly improve the training performance of self-play. Additionally, MiniStar is introduced as an open source environment focused on small-scale combat scenarios, developed to facilitate research in self-play algorithms. The MHO is evaluated on both the AlphaStar888 matrix game and MiniStar environment, and ablation studies further demonstrates its effectiveness in improving the agent’s decision-making capabilities. This work highlight the potential of the MHO to optimize compute resource utilization and improve performance in self-play methods.

UNSTRUCTURED Large language models (LLMs) are rapidly advancing medical artificial intelligence, offering revolutionary changes in health care. These models excel in natural language processing (NLP), enhancing clinical support, diagnosis, treatment, and medical research. Breakthroughs, like GPT-4 and BERT (Bidirectional Encoder Representations from Transformer), demonstrate LLMs’ evolution through improved computing power and data. However, their high hardware requirements are being addressed through technological advancements. LLMs are unique in processing multimodal data, thereby improving emergency, elder care, and digital medical procedures. Challenges include ensuring their empirical reliability, addressing ethical and societal implications, especially data privacy, and mitigating biases while maintaining privacy and accountability. The paper emphasizes the need for human-centric, bias-free LLMs for personalized medicine and advocates for equitable development and access. LLMs hold promise for transformative impacts in health care.