SCHIZOPHRENIA IS characterized by subtle but significant gray matter deficits, particularly affecting the prefrontal and temporal cortices.¹ Morphometric studies have focused on the measurement of cortical volume. The human cerebral cortex, however, is a 6-layered sheet of neural tissue that has been extensively folded, such that approximately two thirds is buried within cortical sulci. We identified sites of cortical thinning in schizophrenia using an automated morphometric method that yields measures of cortical gray matter thickness.