This paper studies the strongly asymmetrical distribution of the population, quality of life and economic development in Portugal. It identifies homogeneous areas supported by an analysis of competitiveness, cohesion and environmental quality dimensions. Drawing on a multivariate approach, its findings reveal differences in terms of development across the country. The study identified groups of regions with common characteristics that go beyond the standard north–south or coastal–inland distinctions. Metropolitan areas and export-oriented regions are clearly distinguishable from the remainder of the country. Economic agglomeration indicators, as gross domestic product per capita, population density, resident foreign population and youth index, among others, are those that reveal greater diversity across the country.