Background/Objectives: Spontaneous macular hole closure is a rare phenomenon, with lamellar hole epiretinal proliferation (LHEP) frequently implicated as a potential mechanism. This study aims to analyze the presence of LHEP in patients with full-thickness macular holes (FTMHs) or lamellar macular holes (LMHs) that closed spontaneously without intervention. Methods: A retrospective longitudinal analysis of optical coherence tomography (OCT) scans was conducted for 73 patients diagnosed with FTMH or LMH in a single institution. Patients with documented spontaneous hole closure were further analyzed for the presence of LHEP, other OCT findings, and clinical characteristics. Results: Of the 73 patients, eight (11%) exhibited spontaneous closure of their macular holes. LHEP was identified in all cases, regardless of hole type (FTMH or LMH). Associated OCT features on diagnosis included VMT in one eye (13%), partial or complete posterior vitreous detachment in seven eyes (88%) and epiretinal membrane in eight eyes (100%). During hole closure, an outer nuclear layer bridge was noted in six eyes (75%). Various extents of outer retinal recovery were noted following closure. After closure, five holes (63%) remained closed without further intervention, while three (38%) reopened and required surgical intervention. Conclusions: Spontaneous macular hole closure is strongly associated with the presence of LHEP, highlighting its potential role in retinal repair mechanisms. While in most patients the spontaneous closure is permanent, surgical intervention may be necessary in cases of hole recurrence.

Purpose: Perfluorocarbon liquids (PFCL) are routinely used in vitreoretinal surgery to flatten the retina and push subretinal fluid. Perfluorocarbon liquid retention is a common complication of vitreoretinal surgery. While retention in the posterior chamber can lead to an inflammatory response, PFCL in the anterior chamber has been shown to be generally well tolerated. Patients and Methods: This report summarizes the findings and treatment of a patient with pathologic myopia and a history of retinal detachment in the left eye repaired with pars plana vitrectomy presenting with one week of blurry vision in the left eye. He was found to have an initial intraocular pressure of 54 mmHg in the left eye along with 1+ conjunctival injection, fine and medium-sized keratic precipitates on the cornea, and 30 cells per high power field. Additionally, there was a retained perfluorocarbon liquid bubble in the anterior chamber from his original retinal detachment repair surgery. Results: After being started on topical steroids and pressure lowering medications, the patient had persistent inflammation and elevated intraocular pressures. The patient’s anterior uveitis and elevated intraocular pressure resolved with removal of the perfluorocarbon liquid bubble by anterior chamber tap. Conclusion: Retained PFCL in the anterior chamber can cause anterior uveitis and can be promptly treated by removal.

Purpose: This study aims to characterize the final stages of eyelid development by assessing infants in the neonatal intensive care unit during a developmental period corresponding to the final weeks of gestation. Methods: Infants admitted to the neonatal intensive care unit were photographed on a weekly basis to generate a neonatal eyelid photo atlas. Morphological features of horizontal palpebral fissure, upper eyelid-to-brow, and medial and lateral intercanthal distances were measured, and the presence of vascularity and skin tones were recorded for each photograph. Results: Ninety-five photographs were obtained from a series of 19 subjects. For each of the anthropomorphic features, growth rates were determined using mixed-effects linear regression analysis. Growth rates for all features were well-described using linear growth. There were no correlations between gestational age and the presence of vascular features, although they were observed less frequently in darker skin tones. Conclusions: While infant populations are subject to variation in eyelid features, the authors report visualized changes in eyelid structures ex utero with measurement of eyelid features. Features demonstrated linear growth rates, and serial photographs offer a route for the longitudinal assessment of eyelid development in the final weeks of gestation.