Urban commercial centers play a critical role in the development of cities, and it is of significant relevance to research the influencing variables of the urban vitality of commercial centers to improve the quality of urban commercial centers. This study employs big data to construct a multiple linear regression model in order to uncover the spatial-distribution characteristics of urban vitality and commercial sectors in commercial centers within the primary urban region of Guangzhou. The findings indicate that the commercial sectors of life, business, finance, and leisure have a substantial influence on the fluctuation of pedestrian flow in commercial centers throughout the day. Conversely, public service commercial sectors do not have a significant impact on pedestrian flow. Furthermore, the effect of various commercial sectors on the vibrancy of urban commercial centers varies, and their performance differs on weekdays and holidays. Additionally, the level of integration among commercial sectors affects the vitality of the city’s commercial space. This research presents empirical facts that can be used to optimize the logical allocation of urban commercial resources in urban planning.