To understand and respond to the common ecological and environmental challenges faced by human beings, this study investigated the relationship between territorial spatial development (TSD), eco-environmental responses, and territorial spatial planning (TSP) from the perspective of human-environment interactions and explores a feasible way to modulate these human-environment interactions by taking China’s TSP practice as an illustrative case. The research results show that (1) the interplay between territorial development, resource utilization, and environmental feedback forms the crux of human-environment interactions. Notably, eco-environment responses, one of which is the spread of germs, coupled with human development and utilization behavior constitute a complete negative feedback loop. Human beings’ adjustment to the unbalanced conditions in these interactions, employing institutions, technology, planning, and other tools, constitutes a positive cycle within human-environment interactions. (2) TSP can regulate the whole process of human-environment interactions through mechanisms such as coordination and control, adaptation and mitigation, and consolidation and restoration. (3) Unreasonable agricultural development and urban expansion have triggered intense negative feedback on the ecological environment. (4) The Chinese government has carried out a top-down TSP reform initiative to establish a unified planning system. This aims to alleviate the adverse ecological and environmental effects caused by TSD and build a more secure territory space pattern. Therefore, nations around the globe should innovate their spatial planning management systems and spatial planning systems, standardize and guide the development and utilization of spatial resources, and coordinate the relationship between humans and the environment.

Industrial prosperity is the prerequisite and foundation of rural revitalization, while rural collective operating construction land (COCL), as an important resource for rural industrial development, has significant theoretical and practical guiding significance regarding whether its market-oriented reform can promote rural industrial integration (RII). This study innovatively combines the synthetic control method (SCM) and mediation effect model to assess the impact of rural collective operating construction land entering the market (COCLEM) on RII, using panel data from 86 counties in Hunan Province (2011–2022), and its underlying mechanisms. This study finds that COCLEM significantly enhances RII, and this conclusion remains robust after a series of tests. A mechanism analysis indicates that COCLEM primarily promotes RII through population agglomeration, fiscal support, and technological upgrading. Furthermore, this study reveals that COCLEM effectively facilitates the extension of the agricultural industry chain and promotes the development of agricultural services. Nevertheless, the improvement of rural infrastructure still requires policy guidance and sustained investment to provide more robust support for RII. Therefore, policymakers should actively formulate a COCLEM policy framework, enhance rural public services, and increase infrastructure investment to continuously promote regional population agglomeration. Local governments should be responsible for ensuring policy implementation and financial support. Additionally, emphasis should be placed on the role of COCLEM in advancing agricultural technology to support RII. Compared with existing research, this study provides new empirical methods and theoretical insights for detailed research on the development of RII.