Background: Guillain-Barré Syndrome (GBS) is a rare post-infectious, immune-mediated inflammatory disorder of the peripheral nervous system that can manifest in multiple distinct forms. It significantly impacts patients’ quality of life, causing both short-term and long-term impairments, including reduced strength, respiratory deficits, functional limitations, decreased endurance, and increased fatigue. This scoping review aimed to assess the impact of physical activity on strength, functional independence, and fatigue in patients with GBS, as well as to identify effective types of physical activity for rehabilitation programs. Methods: A literature search was conducted in March 2024 and updated in June 2024 across PubMed, Embase, Cochrane, Scopus, and Web of Science using predefined inclusion and exclusion criteria. We included full-text, peer-reviewed articles written in English, French, Polish, or Italian that focused on strength, fatigue, and functional independence within the context of physical exercise. Results: A total of 1021 papers were eligible for screening, and after the screening process, 16 papers were included in this review. Conclusions: Physical exercise may enhance strength, reduce fatigue, and promote functional independence in GBS. Recommended interventions often include muscle strengthening, functional training, and endurance exercises. Larger, high-quality studies and further research into chronic fatigue mechanisms are needed to refine long-term rehabilitation strategies.