Smoking adversely affects tuberculosis (TB) outcomes and may be associated with depression and anxiety among people diagnosed with TB in Botswana. We conducted a cross-sectional study among patients newly diagnosed with TB in Gaborone, Botswana, evaluating factors associated with self-reported cigarette smoking. We performed Poisson regression analyses with robust variance to examine whether depressive and anxiety symptoms were associated with smoking. Among 180 participants with TB enrolled from primary health clinics, depressive symptoms were reported in 47 (26.1%) participants and anxiety symptoms were reported in 85 (47.2%) participants. Overall, 45 (25.0%) participants reported current smoking. Depressive symptoms were associated with a higher prevalence of smoking (adjusted prevalence ratio [aPR]: 2.04; 95% confidence interval [CI]: 1.29–3.25) in the adjusted analysis. The association between anxiety symptoms and smoking did not reach statistical significance (aPR: 1.26; 95% CI: 0.77–2.05). Future studies should further investigate these associations when addressing TB care.

RiSE study aims to evaluate a race-based stress-reduction intervention as an effective strategy to improve coping and decrease stress-related symptoms, inflammatory burden, and modify DNA methylation of stress response-related genes in older AA women. This article will describe genomic analytic methods to be utilized in this longitudinal, randomized clinical trial of older adult AA women in Chicago and NYC that examines the effect of the RiSE intervention on DNAm pre- and post-intervention, and its overall influence on inflammatory burden. Salivary DNAm will be measured at baseline and 6 months following the intervention, using the Oragene-DNA kit. Measures of perceived stress, depressive symptoms, fatigue, sleep, inflammatory burden, and coping strategies will be assessed at 4 time points including at baseline, 4 weeks, 8 weeks, and 6 months. Genomic data analysis will include the use of pre-processed and quality-controlled methylation data expressed as beta (β) values. Association analyses will be performed to detect differentially methylated sites on the targeted candidate genes between the intervention and non-intervention groups using the Δβ(changes in methylation) with adjustment for age, health behaviors, early life adversity, hybridization batch, and top principal components of the probes as covariates. To account for multiple testing, we will use FDR adjustment with a corrected p-value of <0.05 regarded as statistically significant. To assess the relationship between inflammatory burden and Δβamong the study samples, we will repeat association analyses with the inclusion of individual inflammation protein measures. ANCOVA will be used because it is more statistically powerful to detect differences.

Background: Getting and maintaining Hepatitis C Virus (HCV) cure is challenging among people experiencing homelessness (PEH) as a result of critical social determinants of health such as unstable housing, mental health disorders, and drug and alcohol use.Objectives: The purpose of this exploratory pilot study was to compare a registered nurse/community health worker (RN/CHW)‐led HCV intervention tailored for PEH, “I am HCV Free,” with a clinic‐based standard of care (cbSOC) for treating HCV. Efficacy was measured by sustained virological response at 12 weeks after stopping antivirals (SVR12), and improvement in mental health, drug and alcohol use, and access to healthcare.Methods: An exploratory randomized controlled trial design was used to assign PEH recruited from partner sites in the Skid Row Area of Los Angeles, California, to the RN/CHW or cbSOC programs. All received direct‐acting antivirals. The RN/CHW group received directly observed therapy in community‐based settings, incentives for taking HCV medications, and wrap‐around services, including connection to additional healthcare services, housing support, and referral to other community services. For all PEH, drug and alcohol use and mental health symptoms were measured at month 2 or 3 and 5 or 6 follow‐up, depending on HCV medication type, while SVR12 was measured at month 5 or 6 follow‐up.Results: Among PEH in the RN/CHW group, 75% (3 of 4) completed SVR12 and all three attained undetectable viral load. This was compared with 66.7% (n = 4 of 6) of the cbSOC group who completed SVR12; all four attained undetectable viral load. The RN/CHW group, as compared to the cbSOC, also showed greater improvements in mental health, and significant improvement in drug use, and access to healthcare services.Discussion: While this study shows significant improvements in drug use and health service access among the RN/‐CHW group, the sample size of the study limits the validity and generalizability of the results. Further studies using larger sample sizes are necessitated.

Research suggests experiences of racial discrimination influence blood pressure outcomes among Black women, but little is known about how coping strategies may influence this relationship. Our study aimed to assess the moderating effects of coping strategies on perceived racial discrimination and blood pressure among young Black mothers. We conducted a secondary analysis on data from the Intergenerational Impact of Genetic and Psychological Factors on Blood Pressure study. Eligible participants were African American or Black women aged 21 and older, who did not present with any cognitive disorder that may obscure reporting data, and who had a biological child who was 3–5 years old at the time of study enrollment. In our analysis, systolic and diastolic blood pressure were the primary outcomes, and experiences of discrimination situations and frequency subscales were the primary predictors. We considered the three subscales of the Coping Strategy Indicator (problem-solving, seeking social support, and avoidance) as moderators. Linear regression models were used. Of the 246 female participants (mean age: 31.3 years; SD = 5.8), the mean systolic and diastolic blood pressures were 114 mmHg (SD = 13.8) and 73 mmHg (SD = 10.9), respectively. The frequency of experiences of perceived racial discrimination was significantly associated with higher systolic blood pressure, but this relationship was moderated among participants with greater seeking social support scores (p = 0.01). There were no significant moderation effects in models with diastolic blood pressure as the outcome. Future studies should examine this relationship longitudinally and further investigate specific coping strategies Black women use to manage perceived racial discrimination.