Background: In the literature, there is no study investigating the relationship between thyroid hormones in pregnancies at 41 weeks and above and the birth timing, labor duration, frequency of fetal distress, premature rupture of membranes (PROM), and maternal hemogram values. Methods: A total of 68 nulliparous pregnant women who were admitted to Basaksehir Cam and Sakura City Hospital with indications of delivery between August 2023 and January 2024, between the ages of 20 and 38 and with no comorbidities, were included in the study. Pregnant women with ≥41 weeks of gestation were classified as the late-term pregnancy group (n = 37), and those between 37 and 38 weeks were classified as the control group (n = 31). The thyrotropin (TSH), free thyroxine (FT4), and hemoglobin levels and relevant parameters were evaluated. Results: The FT4 values of pregnant women diagnosed with fetal distress in the entire population were observed to be statistically significantly lower (p < 0.05). A statistically significant negative linear relationship was detected between the FT4 values of the entire population and the weights of newborns (p < 0.05). It was determined that, as the FT4 values decreased, the newborn weights increased. There was no statistically significant difference between the two groups in terms of the TSH/FT4 values, birth types, labor duration, or postpartum Hb/Htc decrease (p > 0.05). No statistically significant relationship was found between the TSH/FT4 values of the entire population and the diagnosis of PROM, labor duration, or Hb/Htc decrease amount (p > 0.05). Conclusions: TSH/FT4 levels may be important in the mature and late–mature periods of pregnancy. There may be an association between the FT4 levels and the fetal distress risk, type of birth, and newborn weight.

Background: Maternal thyroid hormones play an essential role in fetal growth and pregnancy maintenance. While thyroid dysfunction earlier in pregnancy has been widely studied, the clinical relevance of thyroid function assessed at the time of labor admission remains unclear. This study aimed to evaluate the association between maternal thyroid function parameters measured at labor ward admission and obstetric and neonatal outcomes in term pregnancies. Methods: This retrospective observational study included 664 women with singleton term pregnancies (≥37 weeks) admitted to the labor ward of a tertiary referral center between May 2020 and May 2025. Maternal thyroid-stimulating hormone (TSH) and free thyroxine (FT4) levels were measured at admission. Obstetric outcomes included gestational age at delivery and mode of delivery, while neonatal outcomes comprised birth weight, Apgar scores, and neonatal intensive care unit (NICU) admission. Univariable analyses and multivariable logistic and ordinal regression models adjusted for key obstetric confounders were performed. Results: Gestational age at delivery differed significantly across FT4 tertiles, with higher FT4 levels associated with a greater proportion of late-term deliveries (p = 0.018). Lower FT4 levels were independently associated with lower neonatal birth weight categories after adjustment for gestational age and parity (adjusted OR per 1 SD decrease: 1.19; 95% CI: 1.02–1.38; p = 0.025). Although an inverse association between FT4 tertiles and cesarean delivery due to fetal distress was observed in unadjusted analyses, this association was not retained after multivariable adjustment. Maternal TSH levels were not independently associated with obstetric or neonatal outcomes. No significant associations were observed with Apgar scores or NICU admission. Conclusions: In term pregnancies, maternal FT4 levels measured at labor admission are associated with delivery timing and neonatal birth weight but do not independently predict cesarean delivery due to fetal distress or adverse immediate neonatal outcomes.

Background: Maternal thyroid hormones are essential for fetal development and the maintenance of pregnancy. While thyroid dysfunction earlier in gestation has been extensively studied, the clinical relevance of thyroid function assessed at labor admission remains unclear. This study investigated the association between maternal thyroid function parameters measured at labor ward admission and obstetric and neonatal outcomes in term pregnancies. Methods: In this retrospective observational study, 664 women with singleton term pregnancies (≥37 weeks) admitted to the labor ward of a tertiary referral center were included. Maternal thyroid-stimulating hormone (TSH), free thyroxine (FT4), and admission complete blood count parameters (hemoglobin, hematocrit, white blood cell count, and platelet count) were recorded. Obstetric and neonatal outcomes were compared across FT4 tertiles using univariable and multivariable regression analyses adjusted for key obstetric confounders. Results: Gestational age at delivery differed significantly across FT4 tertiles, with higher FT4 levels associated with a greater proportion of late-term deliveries. Lower FT4 levels were independently associated with lower neonatal birth weight categories after adjustment for gestational age and parity. Admission complete blood count parameters did not differ significantly across FT4 tertiles or gestational age categories. Maternal TSH levels were not independently associated with obstetric or neonatal outcomes, and no significant associations were observed with Apgar scores or NICU admission. Conclusions: In term pregnancies, maternal FT4 levels measured at labor admission are associated with delivery timing and neonatal birth weight but do not independently predict intrapartum fetal distress or adverse immediate neonatal outcomes.

Aim: We aimed to investigate the association between vitamin D deficiency and severity of preeclampsia. Material and Methods: We conducted a case-control study aiming to evaluate vitamin D serum levels in patients with preeclampsia(PE), severe preeclampsia, eclampsia and HELLP syndrome (Hemolysis, Elevated Liver enzymes, Low Platelets). Total number of 69 patients between the ages of 18 and 40 either had a spontaneous vaginal delivery or C-section were included in the study. Results: The demographic data of the patients were similar, and age was higher in severe PE than in the other groups. When body mass index (BMI) was evaluated, the average BMI of the patients in the severe PE group was found to be significantly higher than PE and similar to the other groups. The average vitamin D levels of all groups was 8.75±3.5 and the mean of severe PE was 6.69±3, which was significantly lower than the other groups. The average vitamin D level in PE was 10.99±2.91, and it was higher than all groups and was significantly higher than patients with severe PE and HELLP syndrome. Conclusion: We think that there is a significant relationship between the severity of hypertensive disorders that begin during pregnancy and the degree of vitamin D deficiency. We think that the control of vitamin D level and its addition to the treatment will positively affect the course of the disease in order to prevent hypertensive disorders and reduce the severity of disease.