Background: Maternal thyroid hormones play an essential role in fetal growth and pregnancy maintenance. While thyroid dysfunction earlier in pregnancy has been widely studied, the clinical relevance of thyroid function assessed at the time of labor admission remains unclear. This study aimed to evaluate the association between maternal thyroid function parameters measured at labor ward admission and obstetric and neonatal outcomes in term pregnancies. Methods: This retrospective observational study included 664 women with singleton term pregnancies (≥37 weeks) admitted to the labor ward of a tertiary referral center between May 2020 and May 2025. Maternal thyroid-stimulating hormone (TSH) and free thyroxine (FT4) levels were measured at admission. Obstetric outcomes included gestational age at delivery and mode of delivery, while neonatal outcomes comprised birth weight, Apgar scores, and neonatal intensive care unit (NICU) admission. Univariable analyses and multivariable logistic and ordinal regression models adjusted for key obstetric confounders were performed. Results: Gestational age at delivery differed significantly across FT4 tertiles, with higher FT4 levels associated with a greater proportion of late-term deliveries (p = 0.018). Lower FT4 levels were independently associated with lower neonatal birth weight categories after adjustment for gestational age and parity (adjusted OR per 1 SD decrease: 1.19; 95% CI: 1.02–1.38; p = 0.025). Although an inverse association between FT4 tertiles and cesarean delivery due to fetal distress was observed in unadjusted analyses, this association was not retained after multivariable adjustment. Maternal TSH levels were not independently associated with obstetric or neonatal outcomes. No significant associations were observed with Apgar scores or NICU admission. Conclusions: In term pregnancies, maternal FT4 levels measured at labor admission are associated with delivery timing and neonatal birth weight but do not independently predict cesarean delivery due to fetal distress or adverse immediate neonatal outcomes.
Background: Maternal thyroid hormones are essential for fetal development and the maintenance of pregnancy. While thyroid dysfunction earlier in gestation has been extensively studied, the clinical relevance of thyroid function assessed at labor admission remains unclear. This study investigated the association between maternal thyroid function parameters measured at labor ward admission and obstetric and neonatal outcomes in term pregnancies. Methods: In this retrospective observational study, 664 women with singleton term pregnancies (≥37 weeks) admitted to the labor ward of a tertiary referral center were included. Maternal thyroid-stimulating hormone (TSH), free thyroxine (FT4), and admission complete blood count parameters (hemoglobin, hematocrit, white blood cell count, and platelet count) were recorded. Obstetric and neonatal outcomes were compared across FT4 tertiles using univariable and multivariable regression analyses adjusted for key obstetric confounders. Results: Gestational age at delivery differed significantly across FT4 tertiles, with higher FT4 levels associated with a greater proportion of late-term deliveries. Lower FT4 levels were independently associated with lower neonatal birth weight categories after adjustment for gestational age and parity. Admission complete blood count parameters did not differ significantly across FT4 tertiles or gestational age categories. Maternal TSH levels were not independently associated with obstetric or neonatal outcomes, and no significant associations were observed with Apgar scores or NICU admission. Conclusions: In term pregnancies, maternal FT4 levels measured at labor admission are associated with delivery timing and neonatal birth weight but do not independently predict intrapartum fetal distress or adverse immediate neonatal outcomes.
Purpose: Surgical-site infections (SSI) remain a major complication of cesarean delivery, increasing maternal morbidity, hospital stay, and healthcare costs. Although several risk factors have been identified, the role of maternal nutritional status—particularly the Prognostic Nutritional Index (PNI)—has not been well established in obstetric surgery. Methods: This retrospective case–control study included 190 women who underwent cesarean delivery at a tertiary referral center between 2020 and 2025. Preoperative PNI was calculated using serum albumin and lymphocyte counts obtained within 24 h before surgery. SSI was defined according to the Centers for Disease Control and Prevention criteria. Demographic, perioperative, and postoperative variables were analyzed to evaluate associations between PNI, SSI status, infection severity, and inflammatory markers. Results: A total of 190 women were analyzed, including 98 cases with surgical-site infection (SSI) and 92 controls without SSI. Although preoperative PNI was not an independent predictor of SSI, lower PNI values were associated with more severe infections requiring broad-spectrum antibiotics, longer hospitalization, and higher postoperative C-reactive protein (CRP) levels. A significant inverse correlation was observed between PNI and CRP among patients with SSI ( r = − 0.338, p = 0.001). Longer operative duration and smoking were also associated with an increased risk of SSI. Conclusion: Although PNI was not an independent predictor of SSI, lower values were strongly associated with infection severity and systemic inflammation. Integrating PNI into preoperative risk assessment—alongside body mass index and operative time—may help identify high-risk women. Larger prospective studies are warranted to confirm these findings and to evaluate the impact of nutritional optimization on postoperative outcomes.
25 October 2026 in Journal of Medicine and Palliative Care
Aims: This study aimed to evaluate prenatal care satisfaction among migrant pregnant women in Turkiye using a multidimensional questionnaire and to identify demographic and healthcare-related factors independently associated with satisfaction.Methods: This cross-sectional study included 525 migrant pregnant women receiving routine antenatal care at a tertiary referral hospital. Data were collected using a questionnaire comprising 12 demographic and obstetric questions and 40 satisfaction items covering communication and information, language and interpreter support, respect and cultural sensitivity, accessibility, emotional support and trust, and overall satisfaction and healthcare rights awareness. Internal consistency was assessed using Cronbach’s alpha, and the structural properties of the questionnaire were examined using factor-analytic methods. Group comparisons were performed using nonparametric tests. Independent factors associated with overall satisfaction were evaluated using multivariable linear regression with HC3 robust standard errors. Results: The mean maternal age was 27.54±5.20 years, and 71.2% of participants were Syrian. The questionnaire demonstrated excellent internal consistency (Cronbach's α=0.963). The prespecified six-component solution explained approximately 70.0% of the total variance, while parallel analysis suggested a four-factor empirical structure. The mean overall satisfaction score was 150.0±28.9 out of 200 (3.75±0.72/5). In multivariable analysis, Afghan and Azerbaijani nationality, parity of one or >3, General Health Insurance, Green Card coverage, and unknown insurance status were independently associated with lower satisfaction, whereas postgraduate education, moderate Turkish language proficiency, having an occupation other than housewife, and obtaining healthcare information from social media or interpreters were associated with higher satisfaction. Several household income categories were also associated with higher satisfaction compared with the lowest income category. Conclusion: Migrant pregnant women reported generally favorable overall satisfaction with prenatal care; however, language and interpreter support remained the lowest-rated aspect. These findings highlight the importance of considering language support, access to healthcare information, and culturally responsive care when evaluating prenatal care experiences among migrant women.
Objectives: To evaluate ultrasonographic measurements of the fetal adrenal gland in pregnancies complicated by preeclampsia (PE), with and without fetal growth restriction (FGR), and to assess the utility of adrenal gland dimensions and ratios as potential diagnostic radiologic markers for PE. Methods: This prospective study included pregnant women between 20 and 41 weeks of gestation followed at the Obstetrics and Gynecology Department of Başakşehir Çam and Sakura City Hospital. Participants were divided into three groups: PE (n=63), PE+FGR (n=63), and healthy controls (n=65). Fetal adrenal gland total width and medulla width were measured via ultrasonography. The cortex width = (total width-medulla width) / 2 and the adrenal gland ratio (cortex width/medulla width) were calculated. Statistical analyses were conducted to evaluate differences between groups and to determine the predictive value of the adrenal gland ratio. Results: Fetal adrenal gland total width (adrenal width), cortex width, and adrenal gland ratio were significantly increased in both the PE and PE+FGR groups compared to healthy controls (p<0.001). An adrenal gland ratio ≥2.8 was significantly associated with PE and PE+FGR (p<0.001), showing high diagnostic accuracy. The adrenal gland ratio was not correlated with gestational age. Conclusions: Fetal adrenal gland enlargement, particularly increased cortex width, is associated with preeclampsia and may serve as a noninvasive ultrasonographic biomarker. An adrenal glandthe ratio≥2.8 demonstrates strong diagnostic potential for identifying PE and PE+FGR, offering a valuable tool for early diagnosis and management.