Background/Objectives: Helicobacter pylori (H. pylori) is a significant global health issue causing chronic gastritis, peptic ulcers, and gastric malignancies. Unfortunately, many, particularly in the Middle East, continue to exhibit alarming rates of prevalence. This study aimed to elucidate local epidemiological patterns of H. pylori and examine its histopathological impact on the gastric mucosa. Methods: This retrospective-cross-sectional study included 805 symptomatic adults (329 males, 476 females) who underwent endoscopic evaluation at King Salman Hospital, Ha’il, Saudi Arabia. Biopsies from the antrum and body were processed using routine formalin fixation and paraffin embedding. Staining with hematoxylin–eosin (H&E) and Giemsa permitted assessment of chronic gastritis and detection of H. pylori. Data were evaluated by IBM SPSS (version 23, IBM Corp., Armonk, NY) for associations among infection, histopathology, and patient characteristics. Results: A total of 727 (90.3%) were H. pylori-positive with marginally higher rates in females (91.2%) than males (89.0%). Infection spanned all age groups, reaching 100% in males aged 60–80 years. Overall chronic GI complications were identified in 726 (99.9%), with chronic gastritis being the most profound histopathologically (19.3%). Lymphoid aggregates in 93.0% biopsies reflected a pronounced immune response. Advanced lesions, including metaplasia (0.8%), atrophy (0.3%), and lymphoma (0.1%), were uncommon, though indicative of potential malignant progression. Despite both sexes exhibiting universal symptoms of gastritis, dyspepsia, and heartburn, there were no statistically significant gender-based differences (p > 0.05); specifically, post-H. pylori signs such as vomiting, nausea, weight loss, bleeding or hematemesis occurred equally in all. Histopathology consistently revealed chronic active gastritis with glandular distortion, lymphoplasmacytic infiltration, and occasional mucosal erosions. Giemsa staining further confirmed abundant spiral shapes underscoring a high bacterial load. Conclusion: These findings highlight the age-specific persistently elevating rates of H. pylori significantly associated with chronic gastric inflammatory complications. Although advanced gastric lesions remain rare, reflecting regional epidemiology, early screening, and sleeve treatment efforts, the potential for malignant transformation makes it imperative for continued vigorous eradication, therapy, and vigilant follow-up to avert severe disease outcomes.

Background/Objectives: Helicobacter pylori (H. pylori) is a significant global health issue causing chronic gastritis, peptic-ulcer, and gastric-malignancies. Unfortunately, many, particularly in the Middle East, continue to exhibit alarmingly rates of prevalence. This study aimed to elucidate local epidemiological patterns of H. pylori and examine its histopathological impact on the gastric mucosa. Methods: This retrospective-cross-sectional study included 805 symptomatic adults (329 males, 476 females) who underwent endoscopic evaluation at King Salman Hospital, Ha’il, Saudi Arabia. Biopsies from the antrum and body were processed using routine formalin-fixation and paraffin-embedding. Staining with hematoxylin-eosin (H&E) and Giemsa permitted assessment of chronic gastritis and detection of H. pylori. Data was evaluated by IBM SPSS (version 23, IBM Corp., Armonk, NY) for associations between infection, histopathology, and patient-characteristics. Results: A total of 727 (90.3%) were H. pylori positive with marginally higher rates in females (91.2%) than males (89.0%). Infection spanned all age-groups, reaching 100% in males aged 60–80 years. Chronic GI-complications were identified in 726 (99.9%), with chronic gastritis being the most profound histopathologically (19.3%). Lymphoid-aggregates in 93.0% biopsies, reflected a pronounced immune-response. Advanced lesions, including metaplasia (0.8%), atrophy (0.3%), and lymphoma (0.1%), were uncommon, though indicative of potential malignant-progression. Both sexes exhibited universal symptoms of gastritis, dyspepsia, and heartburn, whereas vomiting, nausea, and weight loss showed minor variability. No statistically significant gender-based differences emerged (p>0.05). Histopathology consistently revealed chronic active-gastritis with glandular-distortion, lymphoplasmacytic infiltration, and occasional mucosal erosions. Giemsa staining further confirmed abundant spiral-shapes underscoring a high bacterial-load. Conclusion: These findings highlight the age-specific persistently elevating rates of H. pylori significantly associated to chronic-gastric-inflammatory complications. Although advanced gastric lesions remain rare, the potential for malignant transformation underscores the importance of early detection, timely eradication therapy, and vigilant follow-up to avert severe disease outcomes.

Background/Objectives : Non-communicable diseases like obesity, diabetes mellitus (DM), and hypertension (HTN) impose major global burdens. Helicobacter pylori infection may worsen these conditions. This study examined the clinical, age-, and gender-specific profiles of H. pylori-infected inpatients and its association with dyslipidemia, obesity, HTN, DM, and other chronic conditions. Methods: Between September 2024 and February 2025, patients were tested using a stool antigen assay (SIMA CHECK–ACON BIOTEC). Demographic data, smoking status, and clinical diagnoses (including kidney, liver, and heart disease) were obtained from hospital records and confirmed with standard criteria. Associations were analyzed using chi-square/Fisher’s tests and logistic regression (adjusted for age, gender, and smoking). Results: Overall, 30.7% (64/208) of inpatients were H. pylori–positive, highest in middle-aged females (42.9%) and lowest in middle-aged males (20.9%). Dyslipidemia rose sharply in males (5.6%→77.1%) versus females (5.7%→58.3%), with infection modestly elevating rates (OR=1.648). Obesity declined with age (males: 36.1%→22.9%; females: 45.7%→20.8%) yet strongly correlated with H. pylori (OR=19.217). HTN (5.6 – 94.3% in males; 11.4 – 100% in females) and DM (16.7 – 80% vs. 17.1 – 95.8%) increased with age but showed no infection link reflecting inflammatory preference. Smoking peaked at 61.1% in younger males. Kidney and heart diseases appeared only in ages 60–85. Overall, the prevalence of comorbidities markedly increased with age. Conclusion: H. pylori infection is common among inpatients, particularly in middle-aged females, and is significantly linked to dyslipidemia and obesity. These findings support targeted screening, especially in females and individuals with metabolic abnormalities, while future studies should assess whether eradication therapy can mitigate chronic metabolic risks.