As unmanned aerial vehicle (UAV) applications expand across logistics, agriculture, and emergency response, safety and security threats are becoming increasingly complex. Addressing these evolving threats, including physical safety and network security threats, requires continued advancement by integrating traditional artificial intelligence (AI) tools such as machine learning (ML) and deep learning (DL), which contribute to significantly enhancing UAV safety and security. Large language models (LLMs), a cutting-edge trend in the AI field, are associated with strong capabilities for learning and adapting across various environments. Their emergence reflects a broader trend toward intelligent systems that may eventually demonstrate behavior comparable to human-level reasoning. This paper summarizes the typical safety and security threats affecting UAVs, reviews the progress of traditional AI technologies, as described in the literature, and identifies strategies for reducing the impact of such threats. It also highlights the limitations of traditional AI technologies and summarizes the current application status of LLMs in UAV safety and security. Finally, this paper discusses the challenges and future research directions for improving UAV safety and security with LLMs. By leveraging their advanced capabilities, LLMs offer potential benefits in critical domains such as urban air traffic management, precision agriculture, and emergency response, fostering transformative progress toward adaptive, reliable, and secure UAV systems that address modern operational complexities.

With the development of unmanned aerial vehicle (UAV) technology, multimachine collaborative operations have become the core model for increasing mission effectiveness. However, large-scale UAV clusters face challenges such as dynamic security threats, heterogeneous data fusion difficulties, and resource-constrained decision-making delays. Traditional single-machine intelligent architectures have limitations when addressing new threats, such as insufficient real-time response capabilities. To address these issues, this paper presnts an LLM-layered collaborative security architecture (LLM-LCSA) for multimachine collaborative security. This architecture optimizes the spatiotemporal fusion efficiency of multisource asynchronous data through cloud–edge–end collaborative deployment, combining an end lightweight LLM, an edge medium LLM, and a cloud-based foundation LLM. Additionally, a Mixture of Experts (MoEs) intelligent algorithm that dynamically activates the most relevant expert models by leveraging a threat–expert association matrix is introduced, thereby increasing the accuracy of complex threat identification and dynamic adaptability. Moreover, a resource-aware multi-objective optimization model is constructed to generate optimal decisions under resource constraints. Simulation results indicate that compared with traditional methods, LLM-LCSA achieves an average 7.92% improvement in the threat detection accuracy, reduces the system’s total response time by 44.52%, and enables resource scheduling during off-peak periods. This architecture provides an efficient, intelligent, and scalable solution for secure collaboration among UAV swarms. Future research should further explore its application potential in 6G network integration and large-scale swarm environments.