Background: Vaginal metastasis should be kept in mind when evaluating the staging tests of all cancers, especially endometrial cancer. Case presentation: We present four patients with vaginal recurrence who recently applied to our clinic. Three cases were of endometrial cancer and one case of rectal cancer. All patients presented with vaginal bleeding. Conclusion: Standard treatment for vaginal metastasis has not yet been established. Therapeutic options for vaginal metastasis—separately or in combination—are surgical resection, radiotherapy, and chemotherapy.

A significant portion of women encounter vaginal infections at some point in their lives. These infections have many effects such as infertility, pelvic inflammatory disease (PID), severe disseminated infections, and complications affecting fetal health during pregnancy. Vaginal infections can be symptomatic or asymptomatic, thereby concealing their presence. This study aimed to determine the frequency and causative agents of vaginal infections in symptomatic and asymptomatic women in Konya. The study included 200 patients aged > 18 years who visited the gynecology clinic for any reason and provided informed consent. Patients who reported at least one of the symptoms of vaginal discharge, burning, or itching were categorized into the symptomatic group, while those without any of these complaints were categorized into the asymptomatic group. Vaginal swab samples collected from the patients were evaluated for bacterial vaginosis (BV) using the Nugent scoring method on Gram-stained smears. Trichomonas vaginalis was investigated through Giemsa-stained microscopic examination and polymerase chain reaction (PCR) analysis. Samples were also cultured on routine media to analyze fungal and bacterial growth. A total of 74% of the patients were symptomatic, and 26% were asymptomatic and were admitted to the gynecology outpatient clinic for reasons other than vaginitis. According to the Nugent scoring system, BV was observed in 21.6% of the symptomatic group and 13.5% of the asymptomatic group. T. vaginalis was detected in only seven patients (3.5%) through microscopic examination and PCR. Among the patients with T. vaginalis, five were in the symptomatic group, and two were in the asymptomatic group. The rate of vaginal candidiasis was found to be 34.5% in the symptomatic group and 21.2% in the asymptomatic group. Aerobic vaginitis was observed in 12.8% of the symptomatic group and 7.7% of the asymptomatic group. The positivity rates for BV, vaginal candidiasis, and trichomoniasis in asymptomatic patients are concerning. Considering the fetal complications and chronic effects of vaginal infections, the decision to establish screening programs in the asymptomatic patient group should be based on national data, considering the prevalence of the pathogen in the region and its outcomes.

Background/Aim: Early differentiation of partial hydatidiform mole from missed abortion remains challenging because clinical and ultrasonographic findings may overlap during the first trimester. The contribution of systemic inflammatory response to this diagnostic process is unclear. This study aimed to compare inflammatory hematological indices derived from routine complete blood counts among patients with partial hydatidiform mole, missed abortion, and uncomplicated early pregnancy, and to assess whether these parameters provide clinically meaningful diagnostic discrimination during early gestation. Methods: Electronic medical records of patients presenting to a university hospital between January 1, 2020, and December 31, 2025, were reviewed retrospectively. Patients with histologically confirmed partial hydatidiform mole (n = 32) were compared with patients with missed abortion (n = 35) and uncomplicated early pregnancy (n = 40). Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), systemic immune-inflammation index (SII), and systemic inflammatory response index (SIRI) were calculated from complete blood counts obtained at initial presentation. Results: Age did not differ significantly among groups (P = 0.860), whereas gestational age differed significantly (P < 0.001). No significant differences were observed among groups for NLR, PLR, MLR, SII, or SIRI (P = 0.740, P = 0.290, P = 0.110, P = 0.850, and P = 0.680, respectively). Gestational age was not significantly correlated with NLR, PLR, MLR, SII, or SIRI (P = 0.154, P = 0.524, P = 0.238, P = 0.371, and P = 0.781, respectively). Receiver operating characteristic analysis showed poor discriminatory performance for all indices, with AUC values ranging from 0.522 to 0.639. Conclusion: Complete blood count-derived inflammatory indices did not provide sufficient diagnostic discrimination to support their use as standalone biomarkers for differentiating partial hydatidiform mole from missed abortion during early gestation. Larger prospective studies are needed to clarify the role of systemic inflammation in this clinical setting.