Sylvano Mania

Dr. Sylvano Mania

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Research Focus & Metrics

Academic Career Length

5Years (2022-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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27 August 2022 in Journal of Orthopaedic Research
Verified
Journal Article
Open access
SMSylvano Mania
Sylvano Mania
CZChristoph Zindel
Christoph Zindel
TGTobias Götschi
Tobias Götschi
Fabio CarrilloFabio Carrillo
Fabio Carrillo
Philipp FürnstahlPhilipp Fürnstahl
Philipp Fürnstahl
ASAndreas Schweizer
Andreas Schweizer
It remains unclear to what extent the interosseous membrane (IOM) is affected through the whole range of motion (ROM) in posttraumatic deformities of the forearm. The purpose of this study is to describe the ligament‐ and bone‐related factors involved in rotational deficit of the forearm. Through three‐dimensional (3D) kinematic simulations on one cadaveric forearm, angular deformities of 5° in four directions (flexion, extension, valgus, varus) were produced at two locations of the radius and the ulna (proximal and distal third). The occurrence of bone collision in pronation and the linear length variation of six parts of the IOM through the whole ROM were compared between the 32 types of forearm deformities. Similar patterns could be observed among four groups: 12 types of deformity presented increased bone collision in pronation, 8 presented an improvement of bone collision with an increase of the mean linear lengthening of the IOM in neutral rotation, 6 had an increased linear lengthening of the IOM in supination with nearly unchanged bone collision in pronation and 6 types presented nearly unchanged bone collision in pronation with a shortening of the mean linear length of IOM in supination or neutral rotation. This kinematic analysis provides a better understanding of the ligament‐ and bone‐related factors expected to cause rotational deficit in forearm deformity and may help to refine the surgical indications of patient‐specific corrective osteotomy.

19 March 2025 in Journal of Clinical Medicine
Verified
Journal Article
Open access
PDF file
MWMichael Wirth
Michael Wirth
MMMauro Maniglio
Mauro Maniglio
BJBenedikt C. Jochum
Benedikt C. Jochum
SMSylvano Mania
Sylvano Mania
LNLadislav Nagy
Ladislav Nagy
LRLisa Reissner
Lisa Reissner
Background: Scaphoid reconstruction after an established non- or malunion is challenging and recent developments have shown the feasibility to reconstruct it with 3D-planned and -printed patient-specific instrumentation. Methods: Our study compared the clinical outcome of computer assisted 3D-reconstructions of the scaphoid using patient-specific guides for primary and revision reconstructions of scaphoid nonunion regarding clinical outcome. Therefore, 39 patients with primary scaphoid nonunion or malunion and 15 patients with nonunion or malunion after a previous operative treatment were treated with patient-specific guides and followed up for a mean of 10.5 months. The consolidation was assessed with a CT-scan, and the time to consolidation was recorded. Pain level, satisfaction, wrist range of motion, and grip strength were measured and compared. Results: The wrist range of motion and grip strength of the two groups were similar, except for the wrist extension, which was significantly reduced in the revision group. Consolidation was observed in 36/39 patients (92%) in the primary group and in 13/15 patients (87%) in the revision group. Our results showed similar clinical results postoperatively between primary reconstructions and revision surgery. Conclusions: The use of 3D-planned and -printed patient-specific instrumentation proves to be similarly effective in revision surgeries for the reconstruction of the scaphoid as it is in primary surgeries.

11 December 2023 in Foot & Ankle International
Verified
Journal Article
Open access
SMSylvano Mania
Sylvano Mania
SBSilvan Beeler
Silvan Beeler
SWStephan Wirth
Stephan Wirth
AVArnd Viehöfer
Arnd Viehöfer
Background: In progressive collapsing foot deformity (PCFD), an internal and plantar rotation of the talus relative to the calcaneus may result in painful peritalar subluxation. Medial soft tissue procedures (eg, spring ligament repair) aim to correct the talar position via the navicular bone if bony correction alone is not sufficient. The effect of the medial soft tissue reconstruction on the talar reposition remains unclear. We hypothesized that a subtalar talocalcaneal ligament reconstruction might be favorable in PCFD to correct talar internal malposition directly. This pilot study aims to evaluate the anatomical feasibility and kinematic behavior of a subtalar ligament reconstruction in PCFD. Methods: Three-dimensional surface model from 10 healthy ankles were produced. A total of 1089 different potential ligament courses were evaluated in a standardized manner. A motion of inversion/eversion and talar internal/external in relation to the calcaneus were simulated and the ligament strain, expressed as a positive length variation, for each ligament was analyzed. The optimal combination for the ligament reconstruction with increased length in internal rotation of the talus, isometric kinematic behavior in inversion/eversion, and extraarticular insertion on talus and calcaneus was selected. Results: A laterodistal orientation of the talar insertion point in respect to the subtalar joint axis and laterodistal deviation of the calcaneal insertion point presents the highest ligament lengthening in internal talar rotation (+0.56 mm [3.8% of total length]) and presented a near-isometric performance in inversion/eversion (+0.01 to −0.01 mm [0.1% of total length]). Conclusion: This kinematic model shows that a ligament reconstruction in the subtalar space presents a pattern of length variation that may stabilize the internal talar rotation without impeding the physiological subtalar motion. Clinical Relevance: This study investigates the optimal location, feasibility, and kinematic behavior of a ligament reconstruction that could help stabilize peritalar subluxation in progressive collapsing foot deformity.

31 May 2022 in Hand Surgery and Rehabilitation
Verified
Journal Article
Closed access
SMSylvano Mania
Sylvano Mania
SBS. Boudabbous
S. Boudabbous
BDB.M.A. Delattre
B.M.A. Delattre
CLC. Lamy
C. Lamy
JBJ-Y. Beaulieu
J-Y. Beaulieu

1 July 2022 in Bone & Joint Open
Verified
Journal Article
Open access
SHSandro Hodel
Sandro Hodel
FSFarah Selman
Farah Selman
SMSylvano Mania
Sylvano Mania
SMSteven Mark Maurer
Steven Mark Maurer
CLChristoph J. Laux
Christoph J. Laux
MFMazda Farshad
Mazda Farshad
Aims: Preprint servers allow authors to publish full-text manuscripts or interim findings prior to undergoing peer review. Several preprint servers have extended their services to biological sciences, clinical research, and medicine. The purpose of this study was to systematically identify and analyze all articles related to Trauma & Orthopaedic (T&O) surgery published in five medical preprint servers, and to investigate the factors that influence the subsequent rate of publication in a peer-reviewed journal. Methods: All preprints covering T&O surgery were systematically searched in five medical preprint servers (medRxiv, OSF Preprints, Preprints.org, PeerJ, and Research Square) and subsequently identified after a minimum of 12 months by searching for the title, keywords, and corresponding author in Google Scholar, PubMed, Scopus, Embase, Cochrane, and the Web of Science. Subsequent publication of a work was defined as publication in a peer-reviewed indexed journal. The rate of publication and time to peer-reviewed publication were assessed. Differences in definitive publication rates of preprints according to geographical origin and level of evidence were analyzed. Results: The number of preprints increased from 2014 to 2020 (p < 0.001). A total of 38.6% of the identified preprints (n = 331) were published in a peer-reviewed indexed journal after a mean time of 8.7 months (SD 5.4 (1 to 27)). The highest proportion of missing subsequent publications was in the preprints originating from Africa, Asia/Middle East, and South America, or in those that covered clinical research with a lower level of evidence (p < 0.001). Conclusion: Preprints are being published in increasing numbers in T&O surgery. Depending on the geographical origin and level of evidence, almost two-thirds of preprints are not subsequently published in a peer-reviewed indexed journal after one year. This raises major concerns regarding the dissemination and persistence of potentially wrong scientific work that bypasses peer review, and the orthopaedic community should discuss appropriate preventive measures. Cite this article: Bone Jt Open 2022;3(7):582–588.

20 October 2026 in Journal of Orthopaedic Research
Verified
Journal Article
Open access
CZChristoph Zindel
Christoph Zindel
SMSylvano Mania
Sylvano Mania
TTTudor Trache
Tudor Trache
MMMichel Meisterhans
Michel Meisterhans
JHJulian Hasler
Julian Hasler
ASAndreas Schweizer
Andreas Schweizer
Forearm rotation depends on the multiplanar bowing of the radius and ulna. Despite the importance of the fundamental 3D anatomic understanding of the forearm for fracture fixation or implant design, all morphological studies have applied only two‐dimensional methods rather than analyzing the true full 3D space. No study investigated the intra‐pair relation of ulna/radius either. Therefore, we processed CT scans of 30 healthy forearms into 3D models. Each bone was divided into 10 segments along the rotation axis, creating 11 cross‐sections with central points. Connecting these central points yielded the Central‐Line. Bowing was quantified as the Bowing‐Index (area under the Central‐Line). Bowing was analyzed in ap, sagittal and the newly defined Main‐Deformity‐Axis (MDA) plane. Maximal radial deviation averaged 6.4 ± 2.3 mm in frontal, 1.3 ± 3.3 mm sagittal, and 7.2 ± 1.8 mm in MDA plane over all forearms. Maximal ulnar deviation was greater with 8.2 ± 2.9 mm frontal, 9.5 ± 1.7 mm sagittal, and 12.3 ± 2.1 mm in MDA. MDA orientation angle (angular tilt in the dorso‐radial direction in the axial plane) was dorso‐radial, with significantly larger out‐of‐plane bowing in the ulna (60.4° vs. 15.0°; p < 0.01), yielding an average intra‐bone‐pair‐difference of 45.5° ± 33.0°. A negative correlation was found between radius and ulna MDA angles ( r = −0.40, p = 0.030). The Bowing Index was higher in the ulna across all planes ( p ≤ 0.011), with a significant negative correlation between Ulna and Radius (MDA plane, r = −0.38, p = 0.036). Distal ulna analysis revealed consistent dorsal and slight ulnar tilt. The Central Line Method enables 3D characterization of forearm bowing, identifying deformity planes beyond frontal/sagittal axes. For the first time, significant negative correlations between radial and ulnar bowing were demonstrated. These insights hold clinical relevance for fracture fixation, osteotomy planning, and implant design.