Background and Aims: Patient satisfaction is a critical metric for assessing the quality of pharmaceutical services in healthcare systems. This study aims to build a questionnaire with various items to comprehensively evaluate patient satisfaction with pharmacy services at the 108 Military Central Hospital and to identify key influential factors in their perception. Methods: The cross‐sectional survey was conducted from August 2023 to October 2023. The face and content validity were assessed by experts. The questionnaire's internal consistency (Cronbach's alpha) and construct validity (exploratory factor analysis) were explored. Multivariate linear regression was used to seek determinants. Results: A total of 457 patients were included for synthesis. The final version of the questionnaire, which had 22 items grouped into four factors (attitude and professional capacity of pharmacy staff, accessibility and transparency, services performed, and infrastructure), showed high consistency and validity. General satisfaction was average (4.09 (SD = 0.628) out of a maximum score of five), with the factor having the lowest score of pharmacist consultants and drug prices despite being the leading national hospital. However, the two factors having the most substantial influence coefficient on satisfaction were the infrastructure (0.433), pharmacy attitude, and professional capacity (0.386). Conclusion: The findings based on the comprehensive questionnaire with 22 items grouped into four factors showed that there were available determinants that needed improvement. Enhancing the quality of the strongest impact aspects of patient satisfaction should be done comprehensively and synchronously. In the case of limited resources, prioritizing actions in phases of time could make them more actionable and beneficial.

Introduction: Linezolid (LZD) plays an important role in the treatment of severe infections caused by Gram-positive bacteria. Thrombocytopenia is regarded as one of the most common side effects of linezolid, which results from the destruction of platelets or myelosuppression. The study aimed to identify the risk factors associated with the development of thrombocytopenia in Vietnamese patients. Methodology: This retrospective, descriptive cross-sectional study was performed on adult patients who received parenteral LZD therapy (1,200 mg/day) in at least 3 days between January 2020 and June 2021 at a tertiary referral hospital in Vietnam. Thrombocytopenia was defined as either a final platelet count of less than 100 G/L or a 25% decrease in platelet count from baseline. Multivariate logistic regression analysis was applied to predict risk factors associated with LZD-induced thrombocytopenia. Results: In the 208 patients included in the study, the average age was 69 and males accounted for 73.1%. LZD-induced thrombocytopenia occurred in 37% of patients. LZD-induced thrombocytopenia was significantly associated with shock (HR = 8.26, 95% CI 3.82 – 17.84, p < 0.001), baseline creatinine clearance (HR = 1.02, 95% CI [1.01 – 1.03], p = 0.002), and duration of LZD treatment of at least 14 days (HR = 4.45, 95% CI [1.83 – 11.05], p = 0.001). Conclusions: The results showed that thrombocytopenia was fairly common in patients using linezolid. Shock, renal failure, and duration of linezolid therapy of at least 14 days were significant risk factors for the incidence of linezolid-induced thrombocytopenia.

Purpose: This study aimed to investigate the current practices of VTE prophylaxis in patients undergoing abdominal-pelvic surgery (PAS) and to identify the factors that influence surgeons’ practice of VTE prophylaxis. Patients and Methods: This two-phase explanatory sequential mixed-method study used chart audits followed by semi-structured interviews based on the theoretical domain framework (TDF). During Phase I, quantitative data from 240 medical records of patients with PAS in April 2023 were audited to measure adherence rates to the standard thromboprophylaxis guidelines. In Phase II, in-depth interviews with 16 surgeons were conducted and analyzed using thematic content analysis based on the TDF framework to understand the determinants of thromboprophylaxis in patients with PAS. Results: Audits of 240 medical records of patients showed the rate of appropriate prophylactic methods was low (11.7%). For patients on anticoagulant prophylaxis, adherence rates regarding drug selection and dosage were high (100% and 89.3%, respectively), whereas adherence rates regarding time of initiation and length of prophylaxis were low (50% and 28.6%, respectively). A qualitative analysis identified 12 theoretical domains relevant to thromboprophylaxis practices among surgeons. The most encountered barriers included concerns about bleeding risk, resource issues, low beliefs about preventive benefits for certain patients with PAS, inadequate knowledge and training, and a lack of protocol and policy. The most encountered enablers included positive beliefs in prophylaxis benefits, mandatory policy and computerized supportive tools, thromboprophylaxis set as patient safety goals, leadership and multidisciplinary working, and training. Conclusion: Significant quality gaps were present in VTE prevention practice for abdominal-pelvic surgical patients, and multiple coexisting factors prevented the full adoption of practice standards. The implementation of an anticoagulation stewardship program is essential for addressing practical issues.

The study aimed to investigate the determinants of pharmacy postgraduates’ satisfaction to suggest essential recommendations to enhance educational quality at Hanoi University of Pharmacy in Vietnam. A cross-sectional survey was conducted among 202 postgraduates using structured questionnaires, with 31 multidimensional questions and 1 question addressing overall satisfaction. Cronbach’s alpha was used to evaluate the questionnaire’s internal consistency, Exploratory Factor Analysis (EFA) identified key factors, and multiple linear regression analysis was applied to assess the impact of these factors. Overall satisfaction had a high mean score of 4.49 out of 5 (SD = 0.602). The final 29 questions were retained and divided into four main factors affecting satisfaction after rotating EFA. The dimension of “Support and Evaluation” was the most influential factor (β = 0.475), followed by “Training Organization”, “Facilities and Library”, and “Lecturers and Curriculum”. The variables with the lowest scores needed much more attention, including digital systems (4.2, SD = 0.852), information technology support (4.32, SD = 0.772), activities boosting lifelong learning skills (4.48, SD = 0.624), and the reasonability of the education program’s structure (4.48, SD = 0.608) and the studying program’s schedule (4.45, SD = 0.607). The findings indicate the issues that should be addressed, and have highlighted that improvements in electronic library accessibility and updated curricula are also recommended to further optimize the educational experience of postgraduate students.

Mục tiêu: Phân tích thực trạng theo dõi nồng độ (Therapeutic drug monitoring-TDM) vancomycin trên bệnh nhân lọc máu liên tục (Continuous renal replacement therapy-CRRT) tại các đơn vị hồi sức, Bệnh viện Trung ương Quân đội (TWQĐ) 108. Đối tượng và phương pháp: Nghiên cứu quan sát tiến cứu từ 01/06/2024 đến 28/02/2025, lựa chọn bệnh nhân trưởng thành điều trị tại các đơn vị hồi sức, sử dụng vancomycin truyền liên tục đồng thời với liệu pháp CRRT và có ít nhất một mẫu định lượng nồng độ. Kết quả: Nghiên cứu ghi nhận tổng cộng 25 bệnh nhân, tất cả bệnh nhân đều sử dụng lọc thẩm tách máu tĩnh mạch – tĩnh mạch liên tục với trung vị tốc độ dịch thải nền là 40,57 ml/giờ/kg. Vancomycin chủ yếu được chỉ định cho các loại nhiễm khuẩn là nhiễm khuẩn hô hấp (84,00%) và sốc nhiễm khuẩn (52,00%). Tất cả bệnh nhân đều được chỉ định liều nạp, mức liều duy trì ban đầu là 23,83 ± 10,91 mg/kg/ngày. Trong tổng số 113 mẫu nồng độ được ghi nhận, 23,01% nồng độ đạt đích và có đến 54,87% nồng độ thuốc có giá trị vượt ngưỡng 25 mg/L. Tỷ lệ bệnh nhân đạt đích nồng độ thuốc giữa các lần TDM dao động rất lớn và đạt cao nhất ở lần thứ 3 (43,75%). Nghiên cứu ghi nhận 3 trường hợp nồng độ vancomycin rất cao (> 60 mg/L), chủ yếu liên quan đến việc chưa điều chỉnh liều duy trì sau khi ngừng CRRT. Kết luận: Thực trạng TDM vancomycin trên bệnh nhân CRRT tại Bệnh viện TWQĐ 108 cho thấy nồng độ vancomycin dao động lớn và tỷ lệ đạt đích còn thấp. Kết quả nhấn mạnh sự cần thiết của một quy trình TDM vancomycin dành riêng cho nhóm bệnh nhân CRRT để nâng cao khả năng đạt đích và an toàn trong điều trị.