Land Degradation Neutrality (LDN) is an ambitious initiative by the United Nations Convention to Combat Desertification (UNCCD) to tackle land degradation. Inspired by the “no net loss” concept, LDN seeks to counterbalance unavoidable land degradation—primarily driven by food systems—through targeted regenerative actions at multiple scales—such as regenerative agriculture or grazing practices that simultaneously support production and preserve land fertility. The objective is to ensure that degradation does not surpass the 2015 baseline. While the UNCCD’s Science–Policy Interface provides guidance and the LDN Target Setting Programme has led many countries to define baselines using agreed indicators (soil organic carbon, land use change, and primary productivity), concrete intervention strategies often remain poorly defined. Moreover, the voluntary nature of LDN has limited its effectiveness. A key shortcoming is the lack of integrated planning. LDN should function as a “Plan of Plans”—a coordinating framework to align policies across sectors and scales, reconciling conflicting agendas in areas such as food, energy, and water. To this end, we advocate for a systemic approach to uncover synergies, manage trade-offs, and guide decision-making in complex socio-ecological landscapes. Land degradation is intricately linked to issues such as food insecurity, land acquisitions, and transboundary water stress. Although LDN is implemented at the national level, its success also depends on accounting for global dynamics—particularly “LDN leaks”, where land degradation is outsourced through international trade in food and raw materials. In an increasingly complex world shaped by globalization, resource depletion, and unpredictable system dynamics, effective responses demand an integrated socio-ecological management approach. LDN is not simply a strategy to address desertification. It offers a comprehensive framework for sustainable resource management, enabling the balancing of trade-offs and the promotion of long-term resilience.