Floods pose significant risks worldwide, impacting lives, infrastructure, and economies. The Susurluk basin, covering 24,319 km² in Türkiye, is highly vulnerable to flooding. This study updates the flood management plan for the basin, integrating hydrological modeling, GIS-based flood mapping, and early warning system evaluations in alignment with the EU Flood Directive. A total of 503 hydrodynamic models (226 one-dimensional and 277 two-dimensional) were developed, analyzing 2116 km of stream length. As a result of the evaluation, the capacities of only 33 streams were found to be sufficient. Flood hazard and risk maps for the Q₅₀, Q₁₀₀, Q₅₀₀, and Q₁₀₀₀ return periods identified the remaining 470 high-risk locations as requiring urgent intervention. Economic risk assessments revealed significant exposure of critical infrastructure, especially in urban areas with populations over 100,000. Furthermore, the study introduces a prioritization framework for intervention that balances socioeconomic costs and environmental impacts. Economic damage assessments estimate potential losses in critical infrastructure, including residential areas, industrial zones, and transportation networks. The findings highlight the importance of proactive flood risk mitigation strategies, particularly in high-risk urban centers. Overall, this study provides a data-driven, replicable model for flood risk management, emphasizing early warning systems, spatial analysis, and structural/non-structural mitigation measures. The insights gained from this research can guide policymakers and urban planners in developing adaptive, long-term flood management strategies for flood-prone regions.