The maize FT-interacting protein (FTIP) gene family represents a group of multiple C2 domain and transmembrane proteins (MCTPs), characterized by their unique structural motifs and membrane-spanning regions., plays crucial roles in intercellular communication and stress responses. Here, we systematically characterized 27 ZmFTIP genes unevenly distributed across 10 maize chromosomes. Phylogenetic analysis with rice, soybean, and Arabidopsis homologs revealed five evolutionary clades with monocot-specific conservation patterns. Promoter cis-element profiling identified hormone-responsive (ABA, JA, auxin) and stress-related motifs, corroborated by differential expression under abiotic stresses and phytohormone treatments. Notably, ZmFTIP18 and ZmFTIP25 showed sustained upregulation under cadmium exposure, while ZmFTIP13 exhibited downregulation. Synteny analysis demonstrated strong conservation with monocot FTIPs, suggesting ancient evolutionary origins. This comprehensive study provides foundational insights into ZmFTIP functional diversification and potential biotechnological applications.