Objectives To compare the effects of interval training and moderate-intensity continuous training (MOD) on body adiposity in humans, and to perform subgroup analyses that consider the type and duration of interval training in different groups. Design Systematic review and meta-analysis. Data sources English-language, Spanish-language and Portuguese-language searches of the electronic databases PubMed and Scopus were conducted from inception to 11 December 2017. Eligibility criteria for selecting studies Studies that met the following criteria were included: (1) original articles, (2) human trials, (3) minimum exercise training duration of 4 weeks, and (4) directly or indirectly compared interval training with MOD as the primary or secondary aim. Results Of the 786 studies found, 41 and 36 were included in the qualitative analysis and meta-analysis, respectively. Within-group analyses showed significant reductions in total body fat percentage (%) (interval training: −1.50 [95% CI −2.14 to −0.86, p<0.00001] and MOD: −1.44 [95% CI −2.00 to −0.89, p<0.00001]) and in total absolute fat mass (kg) (interval training: −1.58 [95% CI −2.74 to −0.43, p=0.007] and MOD: −1.13 [95% CI −2.18 to −0.08, p=0.04]), with no significant differences between interval training and MOD for total body fat percentage reduction (−0.23 [95% CI −1.43 to 0.97], p=0.705). However, there was a significant difference between the groups in total absolute fat mass (kg) reduction (−2.28 [95% CI −4.00 to −0.56], p=0.0094). Subgroup analyses comparing sprint interval training (SIT) with MOD protocols favour SIT for loss of total absolute fat mass (kg) (−3.22 [95% CI −5.71 to −0.73], p=0.01). Supervised training, walking/running/jogging, age (<30 years), study quality and intervention duration (<12 weeks) favourably influence the decreases in total absolute fat mass (kg) observed from interval training programmes; however, no significant effect was found on total body fat percentage (%). No effect of sex or body mass index was observed on total absolute fat mass (kg) or total body fat percentage (%). Conclusion Interval training and MOD both reduce body fat percentage (%). Interval training provided 28.5% greater reductions in total absolute fat mass (kg) than MOD. Trial registration number CRD42018089427.

Background: The present study compared the effects of training and detraining periods of high-intensity interval training (HIIT), moderate-intensity interval training (MIIT) and moderate-intensity continuous training (MICT) on functional performance, body composition, resting blood pressure and heart rate in elderly women nursing home residents. Methods: Forty-six volunteers (age, 80.8 ± 5.2 y; body mass, 69.8 ± 5.2 kg, height, 164.2 ± 4.12 cm) were divided into groups that performed treadmill exercise twice-weekly HIIT (4 bouts of 4-min intervals at 85–95% of the maximal heart rate [HR_max], interspersed by 4 min at 65% HR_max), MIIT (4 bouts of 4 min intervals at 55–75% HR_max, interspersed by 4 min at 45–50% HR_max) and MICT (30-min at 55–75% HR_max). Tests were performed before and after 8 weeks of training and 2 and 4 weeks of detraining. ANCOVA was used to analyze dependent variable changes. Results: After 8 weeks HIIT promoted greater reductions in body mass (HIIT = − 1.6 ± 0.1 kg; MICT = − 0.9 ± 0.1 kg; MIIT = − 0.9 ± 0.1 kg; p = 0.001), fat mass (HIIT = − 2.2 ± 0.1%; MICT = − 0.7 ± 0.1%; MIIT = − 1.2 ± 0.1%; p < 0.001) and resting heart rate (HIIT = − 7.3 ± 0.3%; MICT = − 3.6 ± 0.3%; MIIT = − 5.1 ± 0.3%; p < 0.001) and greater improvement in the chair stand test (HIIT = 3.4 ± 0.1 reps; MICT = 2.5 ± 0.1 reps; MIIT = 3.1 ± 0.1 reps; p < 0.001) when compared to MIIT and MICT. These improvements were sustained after 2 and 4 weeks of detraining only in the HIIT group. Conclusion: HIIT promoted greater benefits for body composition and functional performance than MICT and MIIT and also showed less pronounced effects of detraining. This suggests that the intensity of physical exercise is an important factor to consider when prescribing exercise to the elderly.

We aimed to describe the nutritional and behavioral strategies for rapid weight loss (RWL), investigate the effects of RWL and weight regain in winners and losers, and verify mood state and technical–tactical/time–motion parameters in mixed martial arts. The sample consisted of mixed martial arts athletes after a single real match and was separated into two groups: winners (n = 8; age: 25.4 ± 6.1 years, height: 173.9 ± 0.2 cm, habitual body mass: 89.9 ± 17.3 kg) and losers (n = 7; age: 24.4 ± 6.8 years, height: 178.4 ± 0.9 cm, habitual body mass: 90.8 ± 19.5 kg). Both groups exhibited RWL and weight regain, verified their macronutrient intake, underwent weight and height assessments, and completed two questionnaires (Profile of Mood States and RWL) at (a) 24 hr before weigh-in, (b) weigh-in, (c) postbout, and (d) during a validated time–motion and technical–tactical analysis during the bout. Variance analysis, repeated measures, and a logistic regression analysis were used. The main results showed significant differences between the time points in terms of total caloric intake as well as carbohydrate, protein, and lipid ingestion. Statistical differences in combat analysis were observed between the winners and losers in terms of high-intensity relative time (58 [10–98] s and 32 [1–60] s, respectively), lower limb sequences (3.5 [1.0–7.5] sequences and 1.0 [0.0–1.0] sequences, respectively), and ground and pound actions (2.5 [0.0–4.5] actions and 0.0 [0.0–0.5] actions, respectively), and logistic regression confirmed the importance of high-intensity relative time and lower limb sequences on mixed martial arts performance. RWL and weight regain strategies were related to technical–tactical and time–motion patterns as well as match outcomes. Weight management should be carefully supervised by specialized professionals to reduce health risks and raise competitive performance.

To evaluate the addition of blood flow restriction to passive mobilization in patients in the intensive care unit. The study was a within-patient randomized trial. Two intensive care units in Belém, from September to October 2017. In total, 34 coma patients admitted to the intensive care unit sector, and 20 patients fulfilled the study requirements. All participants received the passive mobilization protocol for lower limbs, and blood flow restriction was added only for one side in a concurrent fashion. Intervention lasted the entire patient’s hospitalization time. Thigh muscle thickness and circumference. In total, 34 subjects were enrolled in the study: 11 were excluded for exclusion criteria, 3 for death, and 20 completed the intervention (17 men and 3 women; mean age: 66 ± 4.3 years). Despite both groups presented atrophy, the atrophy rate was lower in blood flow restriction limb in relation to the control limb (–2.1 vs. –2.8 mm, respectively, in muscle thickness; P = 0.001). In addition, the blood flow restriction limb also had a smaller reduction in the thigh circumference than the control limb (–2.5 vs. –3.6 cm, respectively; P = 0.001). The use of blood flow restriction did not present adverse effects and seems to be a valid strategy to reduce the magnitude of the rate of muscle wasting that occurs in intensive care unit patients.

The purpose of this study was to compare biochemical and hormonal responses between mixed martial arts (MMA) competitors with minimal prefight weight loss and those undergoing rapid weight loss (RWL). Blood samples were taken from 17 MMA athletes (Mean± SD; age: 27.4 ±5.3yr; body mass: 76.2 ± 12.4kg; height: 1.71 ± 0.05m and training experience: 39.4 ± 25 months) before and after each match, according to the official events rules. The no rapid weight loss (NWL, n = 12) group weighed in on the day of the event (~30 min prior fight) and athletes declared not having used RWL strategies, while the RWL group (n = 5) weighed in 24 hr before the event and the athletes claimed to have lost 7.4 ± 1.1kg, approximately 10% of their body mass in the week preceding the event. Results showed significant (p < .05) increases following fights, regardless of group, in lactate, glucose, lactate dehydrogenase (LDH), creatinine, and cortisol for all athletes. With regard to group differences, NWL had significantly (p < .05) greater creatinine levels (Mean± SD; pre to post) (NWL= 101.6 ± 15–142.3 ± 22.9μmol/L and RWL= 68.9 ± 10.6–79.5 ± 15.9μmol/L), while RWL had higher LDH (median [interquartile range]; pre to post) (NWL= 211.5[183–236] to 231[203–258]U/L and RWL= 390[370.5–443.5] to 488[463.5–540.5]U/L) and AST (NWL= 30[22–37] to 32[22–41]U/L and 39[32.5–76.5] to 72[38.5–112.5] U/L) values (NWL versus RWL, p < .05). Post hoc analysis showed that AST significantly increased in only the RWL group, while creatinine increased in only the NWL group. The practice of rapid weight loss showed a negative impact on energy availability and increased both muscle damage markers and catabolic expression in MMA fighters.