Agriculture is one of the three major industries in China, and its level of development occupies an important position in the development of the national economy. At present, China vigorously promotes the strategy of rural revitalization, which provides new opportunities for agricultural modernization. Since modern agriculture and regional economy are coupled in a mutually influencing and constraining relationship, this paper constructs a coupled and coordinated evaluation index system of agricultural modernization and regional economic development. Using the entropy value method and coupled coordination degree model, the comprehensive development level and coordinated development degree of agricultural modernization and regional economic development of 31 provinces, autonomous regions, and cities in China from 2011 to 2020 were evaluated, revealing the time evolution and spatial distribution characteristics of the two systems. The results show that: (1) In the past decade, China’s agricultural modernization and regional economy have made some progress in terms of their respective development levels and the degree of coupling and coordination between them. (2) In terms of spatial evolution, there are obvious regional differences between the two systems, and the coupling coordination degree shows a “ladder” distribution pattern from the east to the central, northeastern, and western parts of the country. (3) Regions with a high level of regional economic development also have a relatively high degree of coupling and coordination between agricultural modernization and regional economic development. Our results provide insights into the economic effects of agricultural modernization in China and provide useful insights into the future direction of agricultural development programs in countries around the world.

China is currently in a strategic opportunity period for green and high-quality development, and developing the digital economy is an important choice to achieve environmental pollution control, improve regional ecological efficiency, and enhance social welfare. In this context, the impact of the digital economy on ecological well-being performance and the role of environmental regulation need to be examined. In this study, the super-efficiency SBM-DEA model was used to measure the level of ecological well-being performance in 30 provinces of China from 2011 to 2019. On this basis, the mediating effect model and spatial Durbin model were adopted to explore the transmission mechanism and regional heterogeneity of the impact of the digital economy on ecological well-being performance. The empirical results show that the digital economy significantly contributes to regional ecological well-being performance in China, and there is significant spatial spillover as well. Moreover, the findings still hold under robustness tests. The results also show that environmental regulation is an important transmission path for the digital economy to enhance regional ecological well-being performance, and the impact of environmental regulation on ecological well-being performance varies by region; specifically, the impact in eastern China is positive but not significant. However, the digital economy plays a significant positive role in promoting ecological well-being performance in the central and western regions, and is more obvious in the central region. Finally, suggestions are put forward to enhance the role of the digital economy in regional ecological well-being performance, which is of great significance for promoting green economic growth and high-quality development.

Platelet-derived growth factor receptors (PDGFRs) have been implicated in a wide array of human malignancies, including medulloblastoma (MB), the most common brain tumor of childhood. Although significant progress in MB biology and therapeutics has been achieved during the past decades, MB remains a horrible challenge to the physicians and researchers. Therefore, novel inhibitors targeting PDGFR signaling pathway may offer great promise for the treatment of MB. In the present study, we investigated the cytotoxicity and mechanisms of cambogin in Daoy MB cells. Our results show that cambogin triggers significant S phase cell cycle arrest and apoptosis via down regulation of cyclin A and E, and activation of caspases. More importantly, further mechanistic studies demonstrated that cambogin inhibits PDGFR signaling in Daoy and genetically defined mouse embryo fibroblast (MEF) cell lines. These results suggest that cambogin is preferentially cytotoxic to cells expressing PDGFR. Our findings may provide a novel approach by targeting PDGFR signaling against MB.

With the rapid development of its economy, environmental governance is becoming more important in China. The Yangtze River Economic Belt (YREB), as the world’s largest inland shipping channel, can lead the country’s regional green economy development. As most research on China’s environmental efficiency focuses on provinces or the east and west regions, this paper examines its energy input and output and environmental effects from the aspects of YREB and non-YREB, breaking through the limitations of previous studies that only used cross-section or panel data for environmental assessment. This paper employs the meta-frontier dynamic SBM model, selects fixed assets as carry-over indicators, and considers the interrelationships between the dynamics variables during 2014–2016. The results are as follows: The overall energy efficiency and CO₂ emission efficiency of YREB are higher than those of non-YREB. The difference in energy consumption, CO₂, and AQI efficiency is large, but the performance of YREB is generally better than that of non-YREB. After setting the meta-frontier, non-YREB is better than YREB, for the main reason that the technology gap values of YREB are smaller than those of non-YREB. Our findings thus suggest that YREB should strengthen technical exchanges and promotion within its region, thereby decreasing regional technology differences, while non-YREB should address environment protection and CO₂ emissions and advocate a low-carbon production mode.