(1) Background: The pro-resolving lipid mediator Resolvin D1 (RvD1) has already shown protective effects in animal models of diabetic retinopathy. This study aimed to investigate the retinal levels of RvD1 in aged (24 months) and younger (3 months) Balb/c mice, along with the activation of macro- and microglia, apoptosis, and neuroinflammation. (2) Methods: Retinas from male and female mice were used for immunohistochemistry, immunofluorescence, transmission electron microscopy, Western blotting, and enzyme-linked immunosorbent assays. (3) Results: Endogenous retinal levels of RvD1 were reduced in aged mice. While RvD1 levels were similar in younger males and females, they were markedly decreased in aged males but less reduced in aged females. Both aged males and females showed a significant increase in retinal microglia activation compared to younger mice, with a more marked reactivity in aged males than in aged females. The same trend was shown by astrocyte activation, neuroinflammation, apoptosis, and nitrosative stress, in line with the microglia and Müller cell hypertrophy evidenced in aged retinas by electron microscopy. (4) Conclusions: Aged mice had sex-related differences in neuroinflammation and apoptosis and low retinal levels of endogenous RvD1.

Background/Objectives: This is a cross-sectional study designed to explore the contribution of personality factors (the Alternative Five Factor Model) and lower order characteristics (responsive distress and self-discipline) to burnout, work addiction, and stress-related growth among Romanian prehospital emergency healthcare workers. Methods: A total of 266 prehospital professionals (41 physicians, 74 nurses, and 151 paramedics) participated in the study out of the 728 invited (36.5% response rate). The age of participants ranged between 20 and 57 years and 67.3% were men. The participants completed the Oldenburg Burnout Inventory, the Dutch Work Addiction Scale (the short version), the Stress-Related Growth Scale, the Zuckerman–Kuhlman Personality Inventory, the Responsive Distress Scale, and the Self-Discipline Scale. Results: The results show that burnout was predicted by age, gender, impulsive sensation seeking, responsive distress, and self-discipline; work addiction was predicted by aggression–hostility, sociability, and responsive distress, while stress-related growth was predicted by age, activity, and self-discipline. Additionally, we found that emergency healthcare workers displayed lower impulsive sensation seeking, neuroticism–anxiety, and aggression–hostility, but displayed higher levels of activity and sociability in comparison with the general Romanian population, although these differences must be interpreted with caution as the general Romanian population tend to be significantly younger. Conclusions: This study provides new insights into the role of personality traits as risk factors for burnout and work addiction, and as protective factors for stress-related growth in prehospital emergency personnel. It is also among the few studies in this field to employ the Alternative Five Factor Model of personality.

The field of emergency medicine (EM) is a high-stress medical specialty. We aim to comparatively investigate burnout, work addiction, and stress-related growth between EM physicians and EM residents. Our sample consists of 117 EM professionals, 41 physicians and 76 residents, from 5 out of the 12 EM county departments in Romania that run residency programs. Methods: An online survey was sent to 461 EM professionals (170 physicians and 291 residents), with a response rate of 25.4%. The survey comprised two sections: the first focused on sociodemographic and professional data, with the second consisting of six validated assessment instruments: the Oldenburg Burnout Inventory, Dutch Work Addiction Scale—short version, Stress-Related Growth Scale, Responsive Distress Scale, Self-Discipline Scale, and Zuckerman–Kuhlman Personality Questionnaire. Both EM physicians and residents reported moderate to high levels of burnout, disengagement, and exhaustion, but there was no significant difference between them. However, physicians exhibited significantly higher levels of work addiction, excessive work, compulsive work, and stress-related growth. No significant differences were found in compulsive work behaviors. Conclusions: Burnout levels are comparable between EM physicians and residents. However, physicians demonstrate higher work addiction but also higher stress-related growth. Personality variables and sleep duration appear to be more influential in predicting burnout than in work addiction or stress-related growth.

In the original publication, there was a mistake in Figure 4 as published