To comprehensively analyze the prevention, diagnosis and management strategies of periprosthetic joint infections(PJIs), provide new ideas for overcoming PJI, and provide references for clinicians. By synthesizing the latest research results at home and abroad, this study deeply analyzed the multidimensional prevention strategies, diagnostic criteria and technological advances, and treatment management strategies for PJI. The management of PJI remains a significant challenge in orthopedic surgery, which warrants focused attention. The prevention of PJI holds paramount priority and should be integrated throughout the perioperative period. Although diagnostic criteria for PJI have undergone multiple updates, the 2011 MSIS criteria remain the most widely adopted, requiring comprehensive evaluation of laboratory, pathological, and imaging examinations for diagnosis. PJI treatment necessitates combined antibiotic and surgical interventions. Antibiotic therapy includes empirical treatment after diagnosis, targeted therapy following pathogen identification, and suppressive antibiotic therapy(SAT) for non-surgical candidates. Surgical options comprise debridement, antibiotics, and implant retention(DAIR), one-stage/two-stage revision, and salvage procedures. Implementation of standardized infection prevention protocols, rational antibiotic use, surgical technical innovations, and advancements in biomaterials have contributed to a reduction in PJI incidence. However, the spread of bacterial resistance and multidrug-resistant organisms in healthcare settings pose new challenges for PJI prevention and treatment. In the future, the research and development of new antimicrobial materials, the innovation of biofilm control technology and the application of precision medicine are expected to further reduce the incidence of PJI, improve the quality of life of patients, and promote a breakthrough in the field of arthroplasty regarding this issue.

Objective: To systematically assess the efficacy and safety of the proximal femoral bionic nail (PFBN) compared with the InterTAN nail in the management of intertrochanteric femoral fractures (IFFs) among elderly individuals. Methods: Eligibility criteria (inclusion and exclusion) were established in accordance with the PICOS framework. Relevant clinical studies were systematically retrieved from both Chinese (CNKI, VIP, and Wanfang Data) and English databases (PubMed, Embase, Web of Science, the Cochrane Library) with a search cutoff date of October 31, 2025. The Risk of Bias in Non-randomized Studies of Interventions (ROBINS-I) tool was employed to appraise methodological quality of the included literature. Meta-analyses of outcome measures, including intraoperative duration, intraoperative haemorrhage, length of hospital stay, postoperative weight-bearing duration, Harris Hip Score (HHS), and internal fixation-related complications, were conducted using RevMan 5.3 and Stata 15 software. Results: Six relevant studies were finally enrolled in the present analysis, consisting of 2 prospective cohort studies and 4 retrospective cohort studies, with a total of 683 participants. Among all cases, 334 patients were allocated to the PFBN group and the remaining 349 cases received InterTAN nail fixation. Meta-analysis outcomes demonstrated no significant inter-group differences in intraoperative blood loss ( P = 0.17), postoperative weight-bearing time ( P = 0.47) and Harris Hip Score (HHS) ( P = 0.11). When compared with the InterTAN nail system, the PFBN group presented a shorter hospital stay ( P = 0.04) and a decreased rate of internal fixation-related complications ( P = 0.01), whereas the PFBN group had a longer operative time ( P = 0.03). Sensitivity analysis further confirmed the good overall stability and reliability of the pooled outcomes in this meta-analysis. Conclusion: Based on the limited evidence from current non-randomized studies, PFBN exhibits potential benefits in shortening hospital duration and reducing the risk of internal fixation-related complications among elderly patients with intertrochanteric femoral fractures. Meanwhile, this implant yields equivalent effects to the InterTAN nail with regard to functional recovery. Given the observational design of all included trials and substantial heterogeneity in several outcomes, these findings warrant cautious interpretation.

Background: Rosa roxburghii Tratt. (Cili), a medicinal-edible herb predominantly distributed in Guizhou Province, exhibits diverse pharmacological properties, including anti-inflammatory, antioxidant, and cell proliferation-promoting effects. Despite its recognized pharmacological value, the therapeutic efficacy and underlying mechanisms in fracture healing remain unexplored. This study aims to systematically investigate its potential mechanisms by integrating network pharmacology and molecular docking. Methods: The components of R. roxburghii Tratt. were retrieved from the PubChem, CNKI, VIP, and WANFANG databases, and their corresponding targets were screened from public databases. The targets of fracture healing were obtained from the GeneCards and OMIM databases. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses revealed the mechanisms of R. roxburghii Tratt. in fracture healing. The potential targets and core components were identified by constructing a protein-protein interaction network and a series of topological networks. Finally, molecular docking was performed to validate the binding of the core targets to the components. Results: Gene Ontology analysis highlighted its regulation of vascular endothelial growth factor signaling pathway, cell migration, epidermal growth factor receptor signaling pathways, and fibroblast growth factor receptor signaling pathways. Kyoto Encyclopedia of Genes and Genomes analysis suggested that R. roxburghii Tratt.’s mechanism may involve key pathways, such as hypoxia-inducible factor 1, phosphoinositide 3-kinase/protein kinase B, mitogen-activated protein kinase, tumor necrosis factor, and ras-associated protein-1 signaling pathway, while topological network analysis identified 4 core targets (tumor necrosis factor, prostaglandin G/H synthase 2, epidermal growth factor receptor, and proto-oncogene tyrosine-protein kinase Src) and 21 core components (naringenin, quercetin, kaempferol, isorhamnetin, luteolin, myricetin, etc), all critically associated with osteogenesis and angiogenesis. Molecular docking confirmed strong binding between these components and targets. Conclusion: These findings propose that R. roxburghii Tratt. may accelerate fracture healing by multitarget, components, and pathways regulating osteogenesis and angiogenesis, providing a scientific basis for its development and utilization.