Background: Subglottic Stenosis (SGS), with increasing numbers of studies, is the most specific and common clinical type of Laryngotracheal Stenosis (LTS). There is rapid publication turnover with newer management introduced and expanding research field. To our knowledge, there is no bibliometric analysis of SGS yet. Methods: In August 2022, we performed a thorough search in the Web of Science Core Collection database using the word “subglottic stenosis,” and “SGS.” The 580 articles were arranged based on correlation. The collected articles were then analyzed with an assessment of relevant factors. Meanwhile, we analyzed the top 100 most-cited articles on SGS. Results: The frequency of publication on SGS has increased substantially over time. The USA has contributed the most articles (n = 301). Vanderbilt University published most of the articles among other institutions (n = 18). Laryngoscope topped the list of journals and has published 89 SGS-related articles. Research hotspots shift from surgical treatment to conservative management. Conclusions: The SGS-related literature has grown rapidly in recent years. This study represents the first bibliometric analysis of scientific articles on SGS. Areas to improve in SGS research can be identified after this analysis of the most impactful articles on this topic.

Background: Rosa roxburghii Tratt. (Cili), a medicinal-edible herb predominantly distributed in Guizhou Province, exhibits diverse pharmacological properties, including anti-inflammatory, antioxidant, and cell proliferation-promoting effects. Despite its recognized pharmacological value, the therapeutic efficacy and underlying mechanisms in fracture healing remain unexplored. This study aims to systematically investigate its potential mechanisms by integrating network pharmacology and molecular docking. Methods: The components of R. roxburghii Tratt. were retrieved from the PubChem, CNKI, VIP, and WANFANG databases, and their corresponding targets were screened from public databases. The targets of fracture healing were obtained from the GeneCards and OMIM databases. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses revealed the mechanisms of R. roxburghii Tratt. in fracture healing. The potential targets and core components were identified by constructing a protein-protein interaction network and a series of topological networks. Finally, molecular docking was performed to validate the binding of the core targets to the components. Results: Gene Ontology analysis highlighted its regulation of vascular endothelial growth factor signaling pathway, cell migration, epidermal growth factor receptor signaling pathways, and fibroblast growth factor receptor signaling pathways. Kyoto Encyclopedia of Genes and Genomes analysis suggested that R. roxburghii Tratt.’s mechanism may involve key pathways, such as hypoxia-inducible factor 1, phosphoinositide 3-kinase/protein kinase B, mitogen-activated protein kinase, tumor necrosis factor, and ras-associated protein-1 signaling pathway, while topological network analysis identified 4 core targets (tumor necrosis factor, prostaglandin G/H synthase 2, epidermal growth factor receptor, and proto-oncogene tyrosine-protein kinase Src) and 21 core components (naringenin, quercetin, kaempferol, isorhamnetin, luteolin, myricetin, etc), all critically associated with osteogenesis and angiogenesis. Molecular docking confirmed strong binding between these components and targets. Conclusion: These findings propose that R. roxburghii Tratt. may accelerate fracture healing by multitarget, components, and pathways regulating osteogenesis and angiogenesis, providing a scientific basis for its development and utilization.