Cannabidiol (CBD) is a non-psychotropic compound found in plants of the Cannabis genus, extensively studied for its therapeutic potential. Research has shown that CBD possesses anti-inflammatory, antioxidant, and regenerative properties, and may contribute to the recovery of neural and bone tissues. In light of the aging population and the resulting rise in neurodegenerative and osteodegenerative conditions, exploring novel therapeutic strategies that promote cellular regeneration is increasingly important. This review aims to compile and critically analyze key studies published in recent decades regarding the effects of CBD on the regeneration of the central and peripheral nervous systems, as well as bone tissue. Findings from in vivo studies indicate that CBD can attenuate inflammatory responses, inhibit oxidative stress, and modulate cellular pathways involved in tissue repair, thereby supporting neuronal and bone regeneration. Moreover, evidence suggests that CBD may protect cells from structural damage, enhancing the functional recovery of affected tissues. Despite scientific advances highlighting cannabidiol as a promising agent for bone and nerve regeneration, its therapeutic application still faces significant limitations. The primary challenge lies in the lack of robust clinical trials in humans, as most existing evidence is derived from in vitro and in vivo studies, making it difficult to confirm its efficacy and safety in clinical contexts. Additionally, CBD’s low bioavailability—due to first-pass hepatic metabolism—hinders dose standardization and reduces the predictability of therapeutic outcomes. Compounding these issues are regulatory constraints and the persistent social stigma surrounding cannabis-derived compounds, which further impede their integration and acceptance in regenerative medicine. Therefore, future research is essential to validate the therapeutic benefits of CBD and to establish its clinical applicability in treating neurological and bone disorders.

Objetivos: Investigar a prevalência de sintomas ansiosos e depressivos, bem como a sobrecarga em cuidadores de idosos e identificar associações destas variáveis com fatores sociodemográficos. Métodos: Estudo transversal com 50 cuidadores, com a aplicação de questionário sociodemográfico, Escala Hospitalar de Ansiedade e Depressão e escala de sobrecarga Zarit Burden Interview. Os dados foram analisados por estatística descritiva, teste do Qui-quadrado e análise multivariada, considerando nível de significância de 5%. Resultados: A maioria dos cuidadores era do sexo feminino (82%), com média de idade de 55,8 ± 11,3 anos e escolaridade variada. Não foram observadas associações significativas entre sintomas de ansiedade ou depressão e variáveis sociodemográficas (p>0,05). Entretanto, identificou-se associação significativa entre sobrecarga percebida e sintomas de alteração de humor (p<0,001). Modelos multivariados indicaram que a sobrecarga esteve associada à intensidade de sintomas ansiosos e depressivos (p=0,0061). Conclusão: A sobrecarga dos cuidadores está associada à ansiedade e depressão, evidenciando vulnerabilidade emocional e risco de adoecimento. Entretanto, os achados devem ser interpretados com cautela, considerando o delineamento transversal do estudo, a amostra recrutada em um único serviço e a ausência de confirmação diagnóstica clínica pelos instrumentos utilizados.