Introduction: Diabetes mellitus and hypertension are major contributors to cardiovascular and renal disease mortality, yet their combined long‐term impact on mortality trends in the United States remains underexplored. This study evaluates national trends in DM and hypertension‐related mortality from 2000 to 2023, analyzing disparities across sex, age groups, race/ethnicity, urbanization, and geographic regions.Methods: We analyzed mortality data from the CDC‐WONDER database, identifying deaths with DM and hypertension as listed causes among adults aged 25 and older. Age‐adjusted mortality rates (AAMRs) per 100,000 were calculated, and temporal trends were assessed using Joinpoint regression to determine annual percentage changes.Results: A total of 2,742,668 DM and hypertension‐related deaths were recorded. The AAMR nearly doubled from 33.7 per 100,000 in 2000 to 66.2 per 100,000 in 2023. A sharp increase was observed from 2018 to 2021 (APC: 16.3 [95% CI: 11.8–19.6]), followed by a decline through 2023. Men had consistently higher mortality rates than females. Mortality rates were highest among older adults (65+ years), Non‐Hispanic Black individuals, and nonmetropolitan populations. The South had the highest mortality rates, with Mississippi and the District of Columbia reporting the greatest burden.Conclusions: DM and hypertension‐related mortality has significantly increased over the past two decades, with notable demographic and geographic disparities. Public health interventions should prioritize high‐risk populations to mitigate mortality trends and improve health equity.

Congenital heart disease (CHD) remains the leading cause of infant mortality due to birth defects in the United States. We analyzed long-term CHD mortality trends across age, sex, and racial groups from 1968 to 2022. We extracted CHD mortality data from the CDC WONDER database (1968-2022), using ICD-8/9/10 codes. Age-adjusted mortality rates (AAMRs) and crude mortality rates (CMRs) were calculated per 100,000 population. Joinpoint regression was used to assess temporal trends in mortality, reporting annual percentage changes (APCs) and average APCs (AAPCs) with 95 % confidence intervals (CIs). From 1968 to 2019, 234,658 CHD-related deaths were recorded. Overall AAMR declined from 3.2 (1968) to 0.8 (2019) per 100,000 (AAPC: -2.7 %; 95 % CI: -2.9 to -2.5). Males consistently had higher AAMRs than females. Racial disparities persisted, with slower declines among Black or African American individuals. Infants under 1 year accounted for 56.0 % of CHD deaths and showed the steepest mortality decline (AAPC: -3.2 %). Mortality rates plateaued in recent years. CHD mortality in the U.S. has declined markedly over the past five decades, though progress has slowed since 2009. Persistent disparities by race and sex emphasize the need for equitable access to specialized CHD care and ongoing public health efforts.

Aim: Cancer and diabetes are major public health concerns, with diabetes linked to increased cancer‐related mortality. However, national trends and disparities remain underexplored. Methods: Using CDC WONDER data, we analysed deaths where both diabetes and cancer were listed as causes. Age‐adjusted mortality rates (AAMRs) were calculated for diabetic cancer patients aged ≥ 25 years and stratified by demographics and geography. Joinpoint regression estimated annual percent changes (APCs) and average annual percent changes (AAPCs). Results: From 1999 to 2019, 699,007 cancer‐related deaths occurred among individuals with diabetes. The overall AAMR increased from 15.06 to 15.23 per 100,000 (AAPC: +0.07%; p = 0.20), with a rise from 1999 to 2003, a decline from 2003 to 2015, and a resurgence from 2015 to 2019. Men (AAMR: 20.83) had higher mortality than women (AAMR: 11.80). Non‐Hispanic Black individuals had the highest AAMRs (23.72), but NH American Indian/Alaska Natives had the largest increase (AAPC: 0.60). The Midwest (AAMR: 17.03) and rural areas (AAMR: 18.70) had the highest mortality, with rural rates rising significantly (AAPC: 0.92). Gastrointestinal cancers were the leading cause (AAMR: 4.31), followed by haematological (AAMR: 1.80), prostate (AAMR: 1.59), and breast cancer (AAMR: 1.38). Conclusion: Cancer‐related mortality in individuals with diabetes has increased, with notable disparities. Targeted interventions, screening, and better diabetes management are essential to reducing risks in high‐risk populations.

Despite advancements in medical management, pericardial disease (PD)-related mortality is on the rise, yet comprehensive data on its prevalence and mortality rates in the United States remains limited. This study aimed to analyze PD-related mortality trends in the United States from 1999 to 2019, focusing on demographic variations based on sex, age, race/ethnicity, geographical regions, and urban-rural distinctions. A descriptive analysis was conducted using death certificate data from the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research database. Mortality rates were assessed among adults aged ≥25 years diagnosed with PD, using International Classification of Diseases-10th Revision codes. Crude mortality rates and age-adjusted mortality rates (AAMRs) were calculated, and temporal trends were analyzed using joinpoint regression. A total of 87,285 PD-related deaths were recorded during this period. AAMR initially decreased from 2.36 in 1999 to 1.70 in 2012, with an annual percentage change of -2.74% (P < 0.001) However, this trend reversed, as AAMR increased significantly to 2.04 by 2019, with an annual percentage change of +2.94% (P < 0.001). Higher mortality rates were observed among males, older adults (≥65 years), and non-Hispanic Black or African American individuals. The Western region exhibited the highest AAMR, whereas rural areas showed slightly elevated mortality rates compared to urban areas after 2012. These findings underscore a resurgence in PD-related mortality, highlighting the urgent need for improved public health strategies to address this growing burden, particularly among vulnerable populations.

Obesity is a major public health crisis in the United States and a key contributor to heart failure (HF). Both conditions independently increase mortality risk, yet national trends in obesity and HF-related deaths remain underexplored across demographic and geographic subgroups. The purpose of this study was to evaluate long-term trends in obesity and HF-related mortality among U.S. adults from 1999 to 2024, with emphasis on disparities by sex, race/ethnicity, age, urbanization, and region. Age-adjusted mortality rates (AAMRs) per 100,000 adults aged ≥25 years were extracted from the Centers for Disease Control and Prevention Wide-Ranging Online Data for Epidemiologic Research database. Deaths with both obesity and HF listed as underlying or contributing causes were included. Temporal trends were assessed using joinpoint regression to calculate annual percent change (APC) and average APC with 95% CIs. From 1999 to 2024, 161,870 obesity and HF-related deaths were identified. The AAMR increased from 1.2 (95% CI: 1.1-1.2) to 4.5 (95% CI: 4.4-4.6), with an average APC of 5.3% (95% CI: 4.9-5.7; P < 0.001). Mortality was higher in men than women (5.0 vs 4.0). Non-Hispanic Black adults had the highest AAMR (7.7), followed by White (4.6) and Hispanic (2.2). The Midwest had the greatest burden (4.8), and rural areas exceeded urban ones. Adults ≥65 years had the highest rate (13.2 in 2024), while those aged 25 to 44 years saw a threefold increase. Obesity and HF-related mortality have more than tripled, with persistent disparities underscoring the need for urgent, equity-focused public health strategies.