Purpose: To investigate the psychological impact of cases of coronavirus disease 19 (COVID-19) on medical staff of Beijing Xiaotangshan Hospital. Methods: The 287 online questionnaires were distributed to medical staff working at Beijing Xiaotangshan Hospital, comprising three main sections and 17 questions: basic information, current departmental position, and the 12-item General Health Questionnaire (GHQ-12). The threshold for emotional distress was defined to be a total score of 4 on the GHQ-12 and above. Results: A total of 255 members of medical staff participating in this study presented an emotional distress rate of 17%. Members who were male, aged 50– 59, married with children, positioned as doctors, and in administration were the population with the highest rate of emotional distress. Furthermore, the severity of emotional distress among those under 30 was significantly lower than those aged 30– 39 and 50– 59. Doctors and other occupations shared a lower level of satisfaction on routine activities compared with nurses, so did staff in the administration compared with those who were working in screening or logistic departments. Besides, males and staff of the confirmation department had more difficulty in concentrating than females and those of the screening department, respectively. Conclusion: Medical staff working at Xiaotangshan Hospital underwent relatively low levels of emotional distress thanks to sufficient medical and psychological preparations. However, special attention should be paid to those who were male, married with children, senior, doctors, in administration, and in the confirmation department.

Overactive bladder syndrome (OAB) has made increasing progress in mechanism and treatment research. Traditional Chinese medicine (TCM) is a common complementary therapy for OAB, and it has been found to be effective. However, the intervention mechanism of TCM in the treatment of OAB is still unclear. The aim of this review is to consolidate the current knowledge about the mechanism of TCM: acupuncture, moxibustion, herbs in treating OAB, and the animal models of OAB commonly used in TCM. Finally, we put forward the dilemma of TCM treatment of OAB and discussed the insufficiency and future direction of TCM treatment of OAB.

Background: The microdeletion of chromosome 13 has been rarely reported. Here, we report a 14-year old Asian female with a de novo microdeletion on 13q12.3. Case presentation: The child suffered mainly from two types of epileptic seizures: partial onset seizures and myoclonic seizures, accompanied with intellectual disability, developmental delay and minor dysmorphic features. The electroencephalogram disclosed slow waves in bilateral temporal, together with generalized spike-and-slow waves, multiple-spike-and-slow waves and slow waves in bilateral occipitotemporal regions. The exome sequencing showed no pathogenic genetic variation in the patient’s DNA sample. While the single nucleotide polymorphism (SNP) array analysis revealed a de novo microdeletion spanning 2.324 Mb, within the cytogenetic band 13q12.3. Conclusions: The epilepsy may be associated with the mutation of KATNAL1 gene or the deletion unmasking a recessive mutation on the other allele, and our findings could provide a phenotypic expansion.

Purpose: To explore the impact of epidemic diseases outbreak on the psychological status of medical workers. Methods: A total of 266 online questionnaires were distributed to medical staff in several mobile cabin hospitals in Beijing. The questionnaires were divided into a General Demographic Characteristics Questionnaire and the 12-item General Health Questionnaire (GHQ-12), and a total score of ≥4 in the GHQ-12 was considered to be a decline in mental health. Results: A total of 266 members of medical staff participated in this study, and 30.1% experienced a decline in mental health recently. The highest prevalence of emotional distress was found among those who were female, married without children, working as doctors and other occupations, aged 30–39 years, working in the confirmation department, supporting the mobile cabin hospitals three times or more, the duration of this support for 1 month or longer, and having a previous state of anxiety and depression. In addition, females experienced higher rates of insomnia due to worry compared to males, as did medical staff in the confirmation department compared to the administration and logistics departments. In the same stressful environment, men and doctors had a greater rate of perceived loss of self-worth than women and nurses. Conclusion: The outbreak of epidemic makes medical workers face the risk of emotional distress. To achieve the purpose of preventing and treating emotional distress of medical workers, we need to carry out continuous and strict research and evaluation on the mental health planning of medical workers, formulate relevant policies and carry out professional psychological intervention.

Background Obstructive sleep apnea hypopnea syndrome (OSAHS) is a sleep disorder characterized by repeated apnea and hypopnea while you're asleep, and the prevalence rate increases annually. Previous research revealed that the fire needle therapy for OSAHS good clinical efficacy but lacked proof from clinical trials. Therefore, we designed this single-arm clinical trial protocol to investigate the effectiveness and safety of treating OSAHS using fire needle therapy. Methods/design: 166 adult subjects with mild to moderate OSAHS, ranging in age from 18 to 70, will be included in this study. All subjects will receive fire needle therapy twice a week for 4 weeks and follow-up for 12 months. The following points will include outcome assessment: (1) baseline;(2) 4 weeks following treatment's start;(3) 3 months following treatment's start; (4) 12 months following treatment's start. The primary outcome of the trial is the AHI index, and the secondary outcomes include oxygen desaturation index(ODI), lowest nocturnal oxygen saturation (LSpO2), percentage of SaO2 < 90% in total sleep time (TS90%), apnea index (AI), hypopnea index (HI), subjective symptoms (by ESS score, TCM syndrome score). Safety assessments include vital sign monitoring, routine blood tests, routine urine tests, blood biochemistry, the skin Reaction Scale, the modified Vancouver scar score, and adverse events. Discussion This single-arm clinical registry study will provide evidence-based medical evidence for the efficacy and safety of fire needle therapy in OSAHS. Trail registration: Chinese Clinical Trial Registry, ChiCTR2100042309. Registered on January 7, 2021.