The advancement of technology and its developments have provided the forensic sciences with many cutting-edge tools, devices, and applications, allowing forensics a better and more accurate understanding of the crime scene, a better and optimal acquisition of data and information, and faster processing, allowing more reliable conclusions to be obtained and substantially improving the scientific investigation of crime. This article describes the technological advances, their impacts, and the challenges faced by forensic specialists in using and implementing these technologies as tools to strengthen their field and laboratory investigations. The systematic review of the scientific literature used the PRISMA^® methodology, analyzing documents from databases such as SCOPUS, Web of Science, Taylor & Francis, PubMed, and ProQuest. Studies were selected using a Cohen Kappa coefficient of 0.463. In total, 63 reference articles were selected. The impact of technology on investigations by forensic science experts presents great benefits, such as a greater possibility of digitizing the crime scene, allowing remote analysis through extended reality technologies, improvements in the accuracy and identification of biometric characteristics, portable equipment for on-site analysis, and Internet of things devices that use artificial intelligence and machine learning techniques. These alternatives improve forensic investigations without diminishing the investigator’s prominence and responsibility in the resolution of cases.