Food safety is a major priority and aims to protect the population from various diseases that can be caused by the food they consume. Food hazards can occur at any stagse of the food chain, from production, supply, processing, distribution to consumption, and can be attributed to biological, chemical, or physical agents. The most common cause of illness resulting from contaminated food is microbiological contamination due to the presence of bacteria, viruses, and parasites. Furthermore, chemical hazards include natural plant toxins, industrial and environmental pollutants that can unintentionally contaminate food, agricultural residues, contaminants from thermal treatment or food processing, and the presence of regulated food ingredients, used for some particular technological purposes, in quantities exceeding maximum permitted limits. Physical hazards are represented by materials that can accidentally contaminate food (glass, metal, plastic objects). To guaranty food safety and protect consumer health, food hazards must be properly managed and controlled. Hazard analysis and critical control point (HACCP) systems and good manufacturing practices (GMP) are important components of these strategies. Hygiene measures for preventing food contamination, aimed to protect consumer health, are addressed to the hygiene and sanitation conditions of food establishments, to food products and personnel. Effective prevention requires an integrated approach that combines the responsibility of food business operators, through the implementation of food safety management systems, with public health measures, consumer education, and a rigorous legislative framework.