This study aimed to investigate the potential use of brown algae Sargassum polycystum as irreversible hydrocolloid (alginate) impression material. Potassium alginate extracted from Sargassum polycystum was prepared in three different compositions (14%, 15%, and 16%) and mixed with other standard components to form an alginate impression material. Prior to that, the purity of potassium alginate was quantified with Fourier Transform Infrared Spectroscopy (FTIR) analysis. As a control material, the alginate impression material from a commercially available product was used. All alginate impression materials were then applied to a die stone model. Dimensional accuracy was measured by calculating the mesiodistal width of incisors in the generated dental cast using a digital caliper 0.01 accuracy (five replications). In addition, to evaluate the dimensional stability, the impression results were poured at four different periods (immediately, 5 min, 10 min, and 15 min). An independent t-test was performed to compare the measurement results with p < 0.05 considered significant. Analytical results confirm that the impression material containing 15% potassium alginate gives the best dimensional accuracy similar to control (p > 0.05). Meanwhile, the optimal dimensional stability was produced in the impression material containing 16% potassium alginate. Our study suggested that brown algae Sargassum polycystum has a promising potential to be used as an alginate impression material in clinical application.

Background/Objectives: Chronic craniofacial inflammation is recognized as a factor in anxiety-like behaviors, yet effective therapeutic options remain limited. Agmatine, a dietary bioactive compound found in fermented foods such as sake lees, exhibits modulatory effects on neural functions, alleviating psychological distress like anxiety associated with local inflammation. Methods: We investigated both the therapeutic and preventive effects of agmatine on anxiety-like behaviors and the related neural basis in a mouse model of persistent craniofacial inflammation induced by complete Freund’s adjuvant (CFA). Results: Comprehensive behavioral assessments, including the elevated plus maze, open field, dark–light box, social interaction, and novel object recognition tests, revealed that therapeutic agmatine administration (1.0 and 30 mg/kg) significantly reduced CFA-induced anxiety-like behaviors, with the higher dose showing more robust and sustained effects across multiple time points. These behavioral improvements were paralleled by reductions in acetylated histone H3, FosB, and c-Fos expression in key anxiety-related brain regions, suggesting a reversal of craniofacial inflammation-associated neural changes. In contrast, preventive agmatine treatment exerted modest and time-dependent behavioral benefits with minimal molecular normalization. Notably, preventive agmatine did not affect general locomotor activity (indicated by total movement distance), indicating that its anxiolytic effects were not confounded by altered locomotor activity. Metabolomic analysis confirmed the presence of agmatine in sake lees (~0.37 mM), supporting the hypothesis that fermented food products might offer dietary routes to emotional resilience. Conclusions: These findings underscore agmatine’s promise as a context-specific epigenetic modulator capable of mitigating anxiety-like behaviors by normalizing inflammation-driven molecular dysregulation in the brain.

Introduction: Craniofacial inflammatory conditions, such as temporomandibular joint disorders and periodontitis, are often linked to heightened anxiety-like responses. Emerging evidence suggests that nutritional strategies may serve as effective, non-pharmacological approaches to mitigate anxiety under such conditions. Objective: To systematically review the evidence on the anxiolytic effects of dietary strategies, such as omega-3 fatty acids, magnesium, probiotics, and curcumin, in individuals or animal models experiencing craniofacial inflammatory conditions. Methods: PubMed, Scopus, and Web of Science were systematically searched for studies published up to January 2025. Studies were included if they evaluated the impact of nutritional interventions on anxiety outcomes in populations with craniofacial inflammation. Relevant data on the study population, interventions, and outcomes were extracted and summarized. Review/Discussion: Five studies were included, comprising human and animal research. Omega-3 fatty acids and magnesium supplementation were associated with reduced anxiety scores and inflammatory markers. Probiotics showed improvement in psychological symptoms and systemic inflammation. Curcumin demonstrated anxiolytic effects by reducing oxidative stress, with combined omega-3 and curcumin showing synergistic benefits. Despite promising results, significant variability in methodologies and outcome measures limits the generalizability of findings. Conclusion: Nutritional strategies hold promise for reducing anxiety in craniofacial inflammatory conditions. Further research with standardized protocols is needed to validate these findings and inform clinical applications.

The present study aimed to report a novel developed technology for disinfecting pathogens in aerosols produced by dental health applications. The proposed method was integrated into a disinfection room installed inside an extraoral dental aerosol suction system. The experimental phase was designed to measure the application of the system during dental care management. These experiments assessed the effectiveness of the proposed mechanism in disinfecting captured micro-organisms. The results showed that the system reduced the quantity and coverage area of harmful splatters and aerosols by ∼50%. Future studies should verify the effectiveness of the approach for measuring the temperature inside the disinfection room and the number of pathogens, including coronavirus, that remain after the disinfection process.