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Miquel Martorell
Department of Nutrition and Dietetics, Faculty of Pharmacy, and Centre for Healthy Living, University of Concepción, Concepción 4070386, Chile

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Review article
Published: 30 August 2021 in Evidence-Based Complementary and Alternative Medicine
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The mangrove plants are the potential sources of foods and remedies for people living in the forests and nearby communities. Xylocarpus granatum J. Koenig is traditionally used to treat various diseases including diarrhea, cholera, dysentery, fever, malaria, and viral infections, among others. To summarize critically the taxonomy, ethnomedicinal, phytochemistry, and pharmacological activities of X. granatum, information was collected from different databases. An up-to-date search (till June 2020) was carried out with the help of various scientific web resources from databases such as PubMed, Science Direct, Google Scholar, and various patent offices (e.g., WIPO, CIPO, and USPTO) using the keywords “Xylocarpus granatum” and then paired with ethnomedicinal use and phytochemical, phytochemistry, and pharmacological activity (in vitro, ex vivo, and in vivo studies). Findings revealed that seeds, fruits, stem bark, leaf, and twigs of X. granatum exhibited a wide range of key phytochemicals including limonoids, phragmalin, limonoid-based alkaloids, mexicanolides, protolimonoids, flavonols, and lactones. The plant possessed potent antioxidant, anticancer, antidiabetic, antimicrobial, antimalarial, antifeedant, and neuroprotective activities. No clinical studies have been reported in the databases. Ethnomedicinal assessment indicated the application of X. granatum in various fields of medical science specially to treat various human ailments, and this was attributed to the presence of enormous alkaloids as confirmed by pharmacological studies. However, to understand the mechanism of action in-depth studies are required. In view of these findings, more research is necessary to explore and characterize the chemical compounds and toxicological aspects of this medicinal mangrove plant. Overall, it can be stated that X. granatum may be one of the hopeful medicinal herbs for the treatment of various diseases in human beings.

ACS Style

Dipta Dey; Cristina Quispe; Rajib Hossain; Divya Jain; Rasel Ahmed Khan; Pracheta Janmeda; Muhammad Torequl Islam; Hafiz Ansar Rasul Suleria; Miquel Martorell; Sevgi Durna Daştan; Manoj Kumar; Yasaman Taheri; Anka Trajkovska Petkoska; Javad Sharifi-Rad. Ethnomedicinal Use, Phytochemistry, and Pharmacology of Xylocarpus granatum J. Koenig. Evidence-Based Complementary and Alternative Medicine 2021, 2021, 1 -16.

AMA Style

Dipta Dey, Cristina Quispe, Rajib Hossain, Divya Jain, Rasel Ahmed Khan, Pracheta Janmeda, Muhammad Torequl Islam, Hafiz Ansar Rasul Suleria, Miquel Martorell, Sevgi Durna Daştan, Manoj Kumar, Yasaman Taheri, Anka Trajkovska Petkoska, Javad Sharifi-Rad. Ethnomedicinal Use, Phytochemistry, and Pharmacology of Xylocarpus granatum J. Koenig. Evidence-Based Complementary and Alternative Medicine. 2021; 2021 ():1-16.

Chicago/Turabian Style

Dipta Dey; Cristina Quispe; Rajib Hossain; Divya Jain; Rasel Ahmed Khan; Pracheta Janmeda; Muhammad Torequl Islam; Hafiz Ansar Rasul Suleria; Miquel Martorell; Sevgi Durna Daştan; Manoj Kumar; Yasaman Taheri; Anka Trajkovska Petkoska; Javad Sharifi-Rad. 2021. "Ethnomedicinal Use, Phytochemistry, and Pharmacology of Xylocarpus granatum J. Koenig." Evidence-Based Complementary and Alternative Medicine 2021, no. : 1-16.

Review article
Published: 17 August 2021 in Oxidative Medicine and Cellular Longevity
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Cardiovascular diseases (CVD) are one of the main causes of mortality in the world. The development of these diseases has a specific factor—alteration in blood platelet activation. It has been shown that phenolic compounds have antiplatelet aggregation abilities and a positive impact in the management of CVD, exerting prominent antioxidant, anti-inflammatory, antitumor, cardioprotective, antihyperglycemic, and antimicrobial effects. Thus, this review is intended to address the antiplatelet activity of phenolic compounds with special emphasis in preventing CVD, along with the mechanisms of action through which they are able to prevent and treat CVD. In vitro and in vivo studies have shown beneficial effects of phenolic compound-rich plant extracts and isolated compounds against CVD, despite that the scientific literature available on the antiplatelet aggregation ability of phenolic compounds in vivo is scarce. Thus, despite the current advances, further studies are needed to confirm the cardioprotective potential of phenolic compounds towards their use alone or in combination with conventional drugs for effective therapeutic interventions.

ACS Style

Javad Sharifi-Rad; Cristina Quispe; Wissam Zam; Manoj Kumar; Susana M. Cardoso; Olivia R. Pereira; Adedayo O. Ademiluyi; Oluwakemi Adeleke; Ana Catarina Moreira; Jelena Živković; Felipe Noriega; Seyed Abdulmajid Ayatollahi; Farzad Kobarfard; Mehrdad Faizi; Miquel Martorell; Natália Cruz-Martins; Monica Butnariu; Iulia Cristina Bagiu; Radu Vasile Bagiu; Mohammed M. Alshehri; William C. Cho. Phenolic Bioactives as Antiplatelet Aggregation Factors: The Pivotal Ingredients in Maintaining Cardiovascular Health. Oxidative Medicine and Cellular Longevity 2021, 2021, 1 -19.

AMA Style

Javad Sharifi-Rad, Cristina Quispe, Wissam Zam, Manoj Kumar, Susana M. Cardoso, Olivia R. Pereira, Adedayo O. Ademiluyi, Oluwakemi Adeleke, Ana Catarina Moreira, Jelena Živković, Felipe Noriega, Seyed Abdulmajid Ayatollahi, Farzad Kobarfard, Mehrdad Faizi, Miquel Martorell, Natália Cruz-Martins, Monica Butnariu, Iulia Cristina Bagiu, Radu Vasile Bagiu, Mohammed M. Alshehri, William C. Cho. Phenolic Bioactives as Antiplatelet Aggregation Factors: The Pivotal Ingredients in Maintaining Cardiovascular Health. Oxidative Medicine and Cellular Longevity. 2021; 2021 ():1-19.

Chicago/Turabian Style

Javad Sharifi-Rad; Cristina Quispe; Wissam Zam; Manoj Kumar; Susana M. Cardoso; Olivia R. Pereira; Adedayo O. Ademiluyi; Oluwakemi Adeleke; Ana Catarina Moreira; Jelena Živković; Felipe Noriega; Seyed Abdulmajid Ayatollahi; Farzad Kobarfard; Mehrdad Faizi; Miquel Martorell; Natália Cruz-Martins; Monica Butnariu; Iulia Cristina Bagiu; Radu Vasile Bagiu; Mohammed M. Alshehri; William C. Cho. 2021. "Phenolic Bioactives as Antiplatelet Aggregation Factors: The Pivotal Ingredients in Maintaining Cardiovascular Health." Oxidative Medicine and Cellular Longevity 2021, no. : 1-19.

Journal article
Published: 19 July 2021
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Genistein is an isoflavone first isolated from the brooming plant Dyer's Genista tinctoria L. and is widely distributed in the Fabaceae family. As an isoflavone, mammalian genistein exerts estrogen-like functions. Several biological effects of genistein have been reported in preclinical studies, such as the antioxidant, anti-inflammatory, antibacterial, and antiviral activities, the effects of angiogenesis and estrogen, and the pharmacological activities on diabetes and lipid metabolism. The purpose of this review is to provide up-to-date evidence of preclinical pharmacological activities with mechanisms of action, bioavailability, and clinical evidence of genistein. The literature was researched using the most important keyword “genistein” from the PubMed, Science, and Google Scholar databases, and the taxonomy was validated using The Plant List. Data were also collected from specialized books and other online resources. The main positive effects of genistein refer to the protection against cardiovascular diseases and to the decrease of the incidence of some types of cancer, especially breast cancer. Although the mechanism of protection against cancer involves several aspects of genistein metabolism, the researchers attribute this effect to the similarity between the structure of soy genistein and that of estrogen. This structural similarity allows genistein to displace estrogen from cellular receptors, thus blocking their hormonal activity. The pharmacological activities resulting from the experimental studies of this review support the traditional uses of genistein, but in the future, further investigations are needed on the efficacy, safety, and use of nanotechnologies to increase bioavailability and therapeutic efficacy.

ACS Style

Javad Sharifi-Rad; Cristina Quispe; Muhammad Imran; Abdur Rauf; Muhammad Nadeem; Tanweer Aslam Gondal; Bashir Ahmad; Muhammad Atif; Mohammad S. Mubarak; Oksana Sytar; Oxana Mihailovna Zhilina; Ekaterina Robertovna Garsiya; Antonella Smeriglio; Domenico Trombetta; Daniel Gabriel Pons; Miquel Martorell; Susana M. Cardoso; Ahmad Faizal Abdull Razis; Usman Sunusi; Ramla Muhammad Kamal; Lia Sanda Rotariu; Monica Butnariu; Anca Oana Docea; Daniela Calina. Genistein: An Integrative Overview of Its Mode of Action, Pharmacological Properties, and Health Benefits. 2021, 2021, 1 .

AMA Style

Javad Sharifi-Rad, Cristina Quispe, Muhammad Imran, Abdur Rauf, Muhammad Nadeem, Tanweer Aslam Gondal, Bashir Ahmad, Muhammad Atif, Mohammad S. Mubarak, Oksana Sytar, Oxana Mihailovna Zhilina, Ekaterina Robertovna Garsiya, Antonella Smeriglio, Domenico Trombetta, Daniel Gabriel Pons, Miquel Martorell, Susana M. Cardoso, Ahmad Faizal Abdull Razis, Usman Sunusi, Ramla Muhammad Kamal, Lia Sanda Rotariu, Monica Butnariu, Anca Oana Docea, Daniela Calina. Genistein: An Integrative Overview of Its Mode of Action, Pharmacological Properties, and Health Benefits. . 2021; 2021 ():1.

Chicago/Turabian Style

Javad Sharifi-Rad; Cristina Quispe; Muhammad Imran; Abdur Rauf; Muhammad Nadeem; Tanweer Aslam Gondal; Bashir Ahmad; Muhammad Atif; Mohammad S. Mubarak; Oksana Sytar; Oxana Mihailovna Zhilina; Ekaterina Robertovna Garsiya; Antonella Smeriglio; Domenico Trombetta; Daniel Gabriel Pons; Miquel Martorell; Susana M. Cardoso; Ahmad Faizal Abdull Razis; Usman Sunusi; Ramla Muhammad Kamal; Lia Sanda Rotariu; Monica Butnariu; Anca Oana Docea; Daniela Calina. 2021. "Genistein: An Integrative Overview of Its Mode of Action, Pharmacological Properties, and Health Benefits." 2021, no. : 1.

Review
Published: 27 June 2021 in Oxidative Medicine and Cellular Longevity
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The genus Peganum includes four species widely distributed in warm temperate to subtropical regions from the Mediterranean to Mongolia as well as certain regions in America. Among these species, Peganum harmala L., distributed from the Mediterranean region to Central Asia, has been studied and its phytochemical profile, traditional folk use, and application in pharmacological and clinical trials are well known. The review is aimed at presenting an insight into the botanical features and geographical distribution of Peganum spp. along with traditional folk uses. This manuscript also reviews the phytochemical profile of Peganum spp. and its correlation with biological activities evidenced by the in vitro and in vivo investigations. Moreover, this review gives us an understanding of the bioactive compounds from Peganum as health promoters followed by the safety and adverse effects on human health. In relation to their multipurpose therapeutic properties, various parts of this plant such as seeds, bark, and roots present bioactive compounds promoting health benefits. An updated search (until December 2020) was carried out in databases such as PubMed and ScienceDirect. Chemical studies have presented beta-carboline alkaloids as the most active constituents, with harmalol, harmaline, and harmine being the latest and most studied among these naturally occurring alkaloids. The Peganum spp. extracts have shown neuroprotective, anticancer, antimicrobial, and antiviral effects. The extracts are also found effective in improving respiratory disorders (asthma and cough conditions), dermatoses, and knee osteoarthritis. Bioactivities and health-enhancing effects of Peganum spp. make it a potential candidate for the formulation of functional foods and pharmaceutical drugs. Nevertheless, adverse effects of this plant have also been described, and therefore new bioproducts need to be studied in depth. In fact, the design of new formulations and nanoformulations to control the release of active compounds will be necessary to achieve successful pharmacological and therapeutic treatments.

ACS Style

Javad Sharifi-Rad; Cristina Quispe; Jesús Herrera-Bravo; Prabhakar Semwal; Sakshi Painuli; Beraat Özçelik; Furkan Ediz Hacıhasanoğlu; Shabnum Shaheen; Surjit Sen; Krishnendu Acharya; Marjan Amirian; Carla Marina Salgado Castillo; María Dolores López; Mauricio Schoebitz; Miquel Martorell; Tamar Goloshvili; Ahmed Al-Harrasi; Ahmed Al-Rawahi; Manoj Kumar; Hafiz Ansar Rasul Suleria; William C. Cho. Peganum spp.: A Comprehensive Review on Bioactivities and Health-Enhancing Effects and Their Potential for the Formulation of Functional Foods and Pharmaceutical Drugs. Oxidative Medicine and Cellular Longevity 2021, 2021, 1 -20.

AMA Style

Javad Sharifi-Rad, Cristina Quispe, Jesús Herrera-Bravo, Prabhakar Semwal, Sakshi Painuli, Beraat Özçelik, Furkan Ediz Hacıhasanoğlu, Shabnum Shaheen, Surjit Sen, Krishnendu Acharya, Marjan Amirian, Carla Marina Salgado Castillo, María Dolores López, Mauricio Schoebitz, Miquel Martorell, Tamar Goloshvili, Ahmed Al-Harrasi, Ahmed Al-Rawahi, Manoj Kumar, Hafiz Ansar Rasul Suleria, William C. Cho. Peganum spp.: A Comprehensive Review on Bioactivities and Health-Enhancing Effects and Their Potential for the Formulation of Functional Foods and Pharmaceutical Drugs. Oxidative Medicine and Cellular Longevity. 2021; 2021 ():1-20.

Chicago/Turabian Style

Javad Sharifi-Rad; Cristina Quispe; Jesús Herrera-Bravo; Prabhakar Semwal; Sakshi Painuli; Beraat Özçelik; Furkan Ediz Hacıhasanoğlu; Shabnum Shaheen; Surjit Sen; Krishnendu Acharya; Marjan Amirian; Carla Marina Salgado Castillo; María Dolores López; Mauricio Schoebitz; Miquel Martorell; Tamar Goloshvili; Ahmed Al-Harrasi; Ahmed Al-Rawahi; Manoj Kumar; Hafiz Ansar Rasul Suleria; William C. Cho. 2021. "Peganum spp.: A Comprehensive Review on Bioactivities and Health-Enhancing Effects and Their Potential for the Formulation of Functional Foods and Pharmaceutical Drugs." Oxidative Medicine and Cellular Longevity 2021, no. : 1-20.

Review
Published: 24 June 2021 in Cancer Cell International
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The study describes the current state of knowledge on nanotechnology and its utilization in medicine. The focus in this manuscript was on the properties, usage safety, and potentially valuable applications of chitosan-based nanomaterials. Chitosan nanoparticles have high importance in nanomedicine, biomedical engineering, discovery and development of new drugs. The manuscript reviewed the new studies regarding the use of chitosan-based nanoparticles for creating new release systems with improved bioavailability, increased specificity and sensitivity, and reduced pharmacological toxicity of drugs. Nowadays, effective cancer treatment is a global problem, and recent advances in nanomedicine are of great importance. Special attention was put on the application of chitosan nanoparticles in developing new system for anticancer drug delivery. Pre-clinical and clinical studies support the use of chitosan-based nanoparticles in nanomedicine. This manuscript overviews the last progresses regarding the utilization, stability, and bioavailability of drug nanoencapsulation with chitosan and their safety.

ACS Style

Javad Sharifi-Rad; Cristina Quispe; Monica Butnariu; Lia Sanda Rotariu; Oksana Sytar; Simona Sestito; Simona Rapposelli; Muhammad Akram; Mehwish Iqbal; Akash Krishna; Nanjangud Venkatesh Anil Kumar; Susana S. Braga; Susana M. Cardoso; Karolina Jafernik; Halina Ekiert; Natália Cruz-Martins; Agnieszka Szopa; Marcelo Villagran; Lorena Mardones; Miquel Martorell; Anca Oana Docea; Daniela Calina. Chitosan nanoparticles as a promising tool in nanomedicine with particular emphasis on oncological treatment. Cancer Cell International 2021, 21, 1 -21.

AMA Style

Javad Sharifi-Rad, Cristina Quispe, Monica Butnariu, Lia Sanda Rotariu, Oksana Sytar, Simona Sestito, Simona Rapposelli, Muhammad Akram, Mehwish Iqbal, Akash Krishna, Nanjangud Venkatesh Anil Kumar, Susana S. Braga, Susana M. Cardoso, Karolina Jafernik, Halina Ekiert, Natália Cruz-Martins, Agnieszka Szopa, Marcelo Villagran, Lorena Mardones, Miquel Martorell, Anca Oana Docea, Daniela Calina. Chitosan nanoparticles as a promising tool in nanomedicine with particular emphasis on oncological treatment. Cancer Cell International. 2021; 21 (1):1-21.

Chicago/Turabian Style

Javad Sharifi-Rad; Cristina Quispe; Monica Butnariu; Lia Sanda Rotariu; Oksana Sytar; Simona Sestito; Simona Rapposelli; Muhammad Akram; Mehwish Iqbal; Akash Krishna; Nanjangud Venkatesh Anil Kumar; Susana S. Braga; Susana M. Cardoso; Karolina Jafernik; Halina Ekiert; Natália Cruz-Martins; Agnieszka Szopa; Marcelo Villagran; Lorena Mardones; Miquel Martorell; Anca Oana Docea; Daniela Calina. 2021. "Chitosan nanoparticles as a promising tool in nanomedicine with particular emphasis on oncological treatment." Cancer Cell International 21, no. 1: 1-21.

Journal article
Published: 17 June 2021 in South African Journal of Botany
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The aim of this study was to analyze the protective role of Bridelia tomentosa Blume fruit against oxidative stress-mediated hepatic damage induced by carbofuran in rats and anti-radical effects of phenolic acids and flavonoids. High-performance liquid chromatography analysis was used to determine the presence of benzoic acid, gallic acid, salicylic acid, quercetin, and rutin which have in-vitro anti-radical effects. In-vivo results suggested that carbofuran produced toxic reactive oxygen species and malondialdehyde which significantly affected serum biochemical parameters, endogenous hepatic antioxidants, and histological architecture of hepatocytes. Carbofuran also induced cytochrome P450 enzymes that increased reactive chemical species mediated cellular damage. However, oral treatment with B. tomentosa fruit methanol extract significantly attenuated the toxicant-induced hepatic toxicity on serum biochemical markers such as alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, gamma-glutamyl transferase, lactate dehydrogenase, total bilirubin, total protein and lipid profile. Co-administration of fruit extract also significantly increased the hepatic endogenous antioxidants superoxide dismutase, catalase, glutathione peroxidase, and reduced glutathione. Cytochrome P450 inhibitory activity and histopathological findings further confirmed the protective role against carbofuran induced damage. It could be concluded that phenolic acids and flavonoids of B. tomentosa fruit might neutralize the toxic free radical mediated oxidative hepatic injury.

ACS Style

Milon Mondal; Sukalyan Kumar Kundu; Muhammad Torequl Islam; Željko Reiner; Miquel Martorell; Javad Sharifi-Rad. Protective effect of Bridelia tomentosa due to its phenolic acids and flavonoids against oxidative stress-mediated hepatic toxicity induced by carbofuran. South African Journal of Botany 2021, 141, 447 -456.

AMA Style

Milon Mondal, Sukalyan Kumar Kundu, Muhammad Torequl Islam, Željko Reiner, Miquel Martorell, Javad Sharifi-Rad. Protective effect of Bridelia tomentosa due to its phenolic acids and flavonoids against oxidative stress-mediated hepatic toxicity induced by carbofuran. South African Journal of Botany. 2021; 141 ():447-456.

Chicago/Turabian Style

Milon Mondal; Sukalyan Kumar Kundu; Muhammad Torequl Islam; Željko Reiner; Miquel Martorell; Javad Sharifi-Rad. 2021. "Protective effect of Bridelia tomentosa due to its phenolic acids and flavonoids against oxidative stress-mediated hepatic toxicity induced by carbofuran." South African Journal of Botany 141, no. : 447-456.

Review article
Published: 15 June 2021 in Evidence-Based Complementary and Alternative Medicine
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Wogonin is a flavonoid found in different plants such as roots of Scutellaria baicalensis Georgi distributed mainly in Asia and Europe. Dried root extracts of S. baicalensis with high content of wogonin, popularly known as “Huang-Qin” or Chinese or baical skullcap, have been used for long time in traditional Chinese medicine. Several health benefits are attributed to wogonin and derivatives showing anti-inflammatory, antiviral, anticancer, and antioxidant effects and more recently antineurodegenerative properties. Preclinical pharmacological activities of wogonin against diverse types of cancer such as breast, colorectal, and human gastric cancer will be presented in this review. In addition, studies on oxidative stress and bioavailability of wogonin will be discussed together with antineurodegenerative potential with special focus on Alzheimer’s disease. Outcomes extracted from the last preclinical studies related to therapeutic applications of wogonin will be commented and updated in this review. The scientific evidence collected in this review aims to encourage transfer of the preclinical evidence of wogonin to new clinical studies.

ACS Style

Javad Sharifi-Rad; Jesús Herrera-Bravo; Luis A. Salazar; Shabnum Shaheen; Seyed Abdulmajid Ayatollahi; Farzad Kobarfard; Muhammad Imran; Ali Imran; Luísa Custódio; María Dolores López; Mauricio Schoebitz; Miquel Martorell; Manoj Kumar; Hafiz Ansar Rasul Suleria; William C. Cho. The Therapeutic Potential of Wogonin Observed in Preclinical Studies. Evidence-Based Complementary and Alternative Medicine 2021, 2021, 1 -9.

AMA Style

Javad Sharifi-Rad, Jesús Herrera-Bravo, Luis A. Salazar, Shabnum Shaheen, Seyed Abdulmajid Ayatollahi, Farzad Kobarfard, Muhammad Imran, Ali Imran, Luísa Custódio, María Dolores López, Mauricio Schoebitz, Miquel Martorell, Manoj Kumar, Hafiz Ansar Rasul Suleria, William C. Cho. The Therapeutic Potential of Wogonin Observed in Preclinical Studies. Evidence-Based Complementary and Alternative Medicine. 2021; 2021 ():1-9.

Chicago/Turabian Style

Javad Sharifi-Rad; Jesús Herrera-Bravo; Luis A. Salazar; Shabnum Shaheen; Seyed Abdulmajid Ayatollahi; Farzad Kobarfard; Muhammad Imran; Ali Imran; Luísa Custódio; María Dolores López; Mauricio Schoebitz; Miquel Martorell; Manoj Kumar; Hafiz Ansar Rasul Suleria; William C. Cho. 2021. "The Therapeutic Potential of Wogonin Observed in Preclinical Studies." Evidence-Based Complementary and Alternative Medicine 2021, no. : 1-9.

Review
Published: 12 June 2021 in Neurochemical Research
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Epilepsy is a related chronic neurological condition of a predisposition for recurrent epileptic seizures, with various manifestations and causes. Although there are antiepileptic drugs, complementary natural therapies are widely used. The purpose of this systematic review was to analyze the antiepileptic/anticonvulsant pharmacological properties of plant-food derived bioactive molecules. In this regard, a systematic review of the PubMed database was made based on the inclusion criteria. Natural compounds/herbs with scientifically proven antiepileptic properties were selected. Experimental pharmacological studies in vitro and in vivo have shown that flavonoids, alkaloids and terpenoids may have anticonvulsant mechanisms similar to the new generation antiepileptic drugs. The relationships of structure-anticonvulsant effect, pharmacological models, seizure-inducing factors and response, effective dose were also analyzed and discussed. The results of in vitro and in vivo pharmacological studies analyzed in this systematic review support the clinical importance of plant-food-derived bioactive molecules for the complementary treatment of epilepsy. Thus, are opened new perspectives to develop new natural anticonvulsant drugs.

ACS Style

Javad Sharifi-Rad; Cristina Quispe; Jesús Herrera-Bravo; Miquel Martorell; Farukh Sharopov; Tugba Boyunegmez Tumer; Begum Kurt; Chintha Lankatillake; Anca Oana Docea; Ana Catarina Moreira; Daniel A. Dias; Mohamad Fawzi Mahomoodally; Devina Lobine; Natália Cruz-Martins; Manoj Kumar; Daniela Calina. A Pharmacological Perspective on Plant-derived Bioactive Molecules for Epilepsy. Neurochemical Research 2021, 1 -21.

AMA Style

Javad Sharifi-Rad, Cristina Quispe, Jesús Herrera-Bravo, Miquel Martorell, Farukh Sharopov, Tugba Boyunegmez Tumer, Begum Kurt, Chintha Lankatillake, Anca Oana Docea, Ana Catarina Moreira, Daniel A. Dias, Mohamad Fawzi Mahomoodally, Devina Lobine, Natália Cruz-Martins, Manoj Kumar, Daniela Calina. A Pharmacological Perspective on Plant-derived Bioactive Molecules for Epilepsy. Neurochemical Research. 2021; ():1-21.

Chicago/Turabian Style

Javad Sharifi-Rad; Cristina Quispe; Jesús Herrera-Bravo; Miquel Martorell; Farukh Sharopov; Tugba Boyunegmez Tumer; Begum Kurt; Chintha Lankatillake; Anca Oana Docea; Ana Catarina Moreira; Daniel A. Dias; Mohamad Fawzi Mahomoodally; Devina Lobine; Natália Cruz-Martins; Manoj Kumar; Daniela Calina. 2021. "A Pharmacological Perspective on Plant-derived Bioactive Molecules for Epilepsy." Neurochemical Research , no. : 1-21.

Review article
Published: 01 June 2021 in Evidence-Based Complementary and Alternative Medicine
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This study aimed to summarize the available data on the ethnomedicinal and phytopharmacological activities of Heliotropium indicum L. based on database reports. For this purpose, an up-to-date literature search was carried out in the Google Scholar, Scopus, Springer Link, Web of Science, ScienceDirect, ResearchGate, PubMed, Chem Spider, Elsevier, BioMed Central, and patent offices (e.g., USPTO, CIPO, NPI, Google patents, and Espacenet) for the published materials. The findings suggest that the plant contains many important phytochemicals, including pyrrolizidine alkaloids, indicine, echinitine, supinine, heleurine, heliotrine, lasiocarpine, acetyl indicine, indicinine, indicine N-oxide, cynoglossine, europine N-oxide, heleurine N-oxide, heliotridine N-oxide, heliotrine N-oxide, heliotrine, volatile oils, triterpenes, amines, and sterols. Scientific reports revealed that the herb showed antioxidant, analgesic, antimicrobial, anticancer, antituberculosis, antiplasmodial, anticataract, antifertility, wound healing, antiinflammatory, antinociceptive, antihyperglycemic, anthelmintic, diuretic, antitussive, antiglaucoma, antiallergic, and larvicidal activity. In conclusion, in vitro studies with animal models seem to show the potential beneficial effects of H. indicum against a wide variety of disorders and as a source of phytotherapeutic compounds. However, clinical studies are necessary to confirm the effects observed in animal models, determine the toxicity of the therapeutic dose and isolate the truly bioactive components.

ACS Style

Chandan Sarkar; Milon Mondal; Bilkis Khanom; Monir Hossain; Solayman Hossain; Antoni Sureda; Muhammad Torequl Islam; Miquel Martorell; Manoj Kumar; Javad Sharifi-Rad; Ahmed Al-Harrasi; Ahmed Al-Rawahi. Heliotropium indicum L.: From Farm to a Source of Bioactive Compounds with Therapeutic Activity. Evidence-Based Complementary and Alternative Medicine 2021, 2021, 1 -21.

AMA Style

Chandan Sarkar, Milon Mondal, Bilkis Khanom, Monir Hossain, Solayman Hossain, Antoni Sureda, Muhammad Torequl Islam, Miquel Martorell, Manoj Kumar, Javad Sharifi-Rad, Ahmed Al-Harrasi, Ahmed Al-Rawahi. Heliotropium indicum L.: From Farm to a Source of Bioactive Compounds with Therapeutic Activity. Evidence-Based Complementary and Alternative Medicine. 2021; 2021 ():1-21.

Chicago/Turabian Style

Chandan Sarkar; Milon Mondal; Bilkis Khanom; Monir Hossain; Solayman Hossain; Antoni Sureda; Muhammad Torequl Islam; Miquel Martorell; Manoj Kumar; Javad Sharifi-Rad; Ahmed Al-Harrasi; Ahmed Al-Rawahi. 2021. "Heliotropium indicum L.: From Farm to a Source of Bioactive Compounds with Therapeutic Activity." Evidence-Based Complementary and Alternative Medicine 2021, no. : 1-21.

Review article
Published: 01 June 2021 in Frontiers in Endocrinology
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Type 2 diabetes Mellitus (T2DM) prevalence has significantly increased worldwide in recent years due to population age, obesity, and modern sedentary lifestyles. The projections estimate that 439 million people will be diabetic in 2030. T2DM is characterized by an impaired β-pancreatic cell function and insulin secretion, hyperglycemia and insulin resistance, and recently the epigenetic regulation of β-pancreatic cells differentiation has been underlined as being involved. It is currently known that several bioactive molecules, widely abundant in plants used as food or infusions, have a key role in histone modification and DNA methylation, and constituted potential epidrugs candidates against T2DM. In this sense, in this review the epigenetic mechanisms involved in T2DM and protein targets are reviewed, with special focus in studies addressing the potential use of phytochemicals as epidrugs that prevent and/or control T2DM in vivo and in vitro. As main findings, and although some controversial results have been found, bioactive molecules with epigenetic regulatory function, appear to be a potential replacement/complementary therapy of pharmacological hypoglycemic drugs, with minimal side effects. Indeed, natural epidrugs have shown to prevent or delay the T2DM development and the morbidity associated to dysfunction of blood vessels, eyes and kidneys due to sustained hyperglycemia in T2DM patients.

ACS Style

Karina Ramírez-Alarcón; Montserrat Victoriano; Lorena Mardones; Marcelo Villagran; Ahmed Al-Harrasi; Ahmed Al-Rawahi; Natália Cruz-Martins; Javad Sharifi-Rad; Miquel Martorell. Phytochemicals as Potential Epidrugs in Type 2 Diabetes Mellitus. Frontiers in Endocrinology 2021, 12, 1 .

AMA Style

Karina Ramírez-Alarcón, Montserrat Victoriano, Lorena Mardones, Marcelo Villagran, Ahmed Al-Harrasi, Ahmed Al-Rawahi, Natália Cruz-Martins, Javad Sharifi-Rad, Miquel Martorell. Phytochemicals as Potential Epidrugs in Type 2 Diabetes Mellitus. Frontiers in Endocrinology. 2021; 12 ():1.

Chicago/Turabian Style

Karina Ramírez-Alarcón; Montserrat Victoriano; Lorena Mardones; Marcelo Villagran; Ahmed Al-Harrasi; Ahmed Al-Rawahi; Natália Cruz-Martins; Javad Sharifi-Rad; Miquel Martorell. 2021. "Phytochemicals as Potential Epidrugs in Type 2 Diabetes Mellitus." Frontiers in Endocrinology 12, no. : 1.

Journal article
Published: 18 May 2021 in Current Medicinal Chemistry
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Background: Triterpenes are a large group of secondary metabolites mainly produced by plants with a variety of biological activities, including potential antitumor effects. Hepatocellular carcinoma (HCC) is a very common primary liver disease spread worldwide. The treatment can consist of surgical intervention, radiotherapy, immunotherapy and chemotherapeutic drugs. These drugs mainly include tyrosine multikinase inhibitors, although their use is limited by the underlying liver disease and displays side effects. For that reason, the utility of natural compounds such as triterpenes to treat HCC is an interesting line of research. No clinical studies are reported in humans so far. Objective: The aim of the present work is to review the knowledge about the effects of triterpenes as a possible coadjuvant tool to treat HCC. Results: In vitro and xenograft models have pointed out the cytotoxic and anti-proliferative effects as well as improvements in tumor growth and development of many triterpenes. In addition, they have also shown to be chemosensitizing agents when co-administered with chemotherapeutic agents. The mechanisms of action are diverse and involve the participation of mitogen-activated protein kinases, including JNK, p38 MAPK and ERK, and the survival-associated PI3K / Akt signaling pathway. However, no clinical studies are still reported in humans. Conclusion: Triterpenes could become a future strategy to address HCC or at least improve results when administered in combination with chemotherapeutic agents.

ACS Style

Antoni Sureda; Miquel Martorell; Xavier Capó; Margalida Monserrat-Mesquida; Maria Magdalena Quetglas-Llabrés; Mahsa Rasekhian; Seyed M. Nabavi; Silvia Tejada. Antitumor Effects of Triterpenes in Hepatocellular Carcinoma. Current Medicinal Chemistry 2021, 28, 2465 -2484.

AMA Style

Antoni Sureda, Miquel Martorell, Xavier Capó, Margalida Monserrat-Mesquida, Maria Magdalena Quetglas-Llabrés, Mahsa Rasekhian, Seyed M. Nabavi, Silvia Tejada. Antitumor Effects of Triterpenes in Hepatocellular Carcinoma. Current Medicinal Chemistry. 2021; 28 (13):2465-2484.

Chicago/Turabian Style

Antoni Sureda; Miquel Martorell; Xavier Capó; Margalida Monserrat-Mesquida; Maria Magdalena Quetglas-Llabrés; Mahsa Rasekhian; Seyed M. Nabavi; Silvia Tejada. 2021. "Antitumor Effects of Triterpenes in Hepatocellular Carcinoma." Current Medicinal Chemistry 28, no. 13: 2465-2484.

Review article
Published: 11 May 2021 in Frontiers in Pharmacology
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The genus Cinnamomum includes a number of plant species largely used as food, food additives and spices for a long time. Different traditional healing systems have used these plants as herbal remedies to cure diverse ailments. The aim of this comprehensive and updated review is to summarize the biodiversity of the genus Cinnamomum, its bioactive compounds, the mechanisms that underlie the pharmacological activities and molecular targets and toxicological safety. All the data in this review have been collected from databases and recent scientific literature including Web of Science, PubMed, ScienceDirect etc. The results showed that the bioactive compounds of Cinnamomum species possess antimicrobial, antidiabetic, antioxidant, anti-inflammatory, anticancer and neuroprotective effects. The preclinical (in vitro/in vivo) studies provided the possible molecular mechanisms of these action. As a novelty, recent clinical studies and toxicological data described in this paper support and confirm the pharmacological importance of the genus Cinnamomum. In conclusion, the obtained results from preclinical studies and clinical trials, as well as reduced side effects provide insights into future research of new drugs based on extracts and bioactive compounds from Cinnamomum plants.

ACS Style

Javad Sharifi-Rad; Abhijit Dey; Niranjan Koirala; Shabnum Shaheen; Nasreddine El Omari; Bahare Salehi; Tamar Goloshvili; Nathália Cristina Cirone Silva; Abdelhakim Bouyahya; Sara Vitalini; Elena M. Varoni; Miquel Martorell; Anna Abdolshahi; Anca Oana Docea; Marcello Iriti; Daniela Calina; Francisco Les; Víctor López; Constantin Caruntu. Cinnamomum Species: Bridging Phytochemistry Knowledge, Pharmacological Properties and Toxicological Safety for Health Benefits. Frontiers in Pharmacology 2021, 12, 1 .

AMA Style

Javad Sharifi-Rad, Abhijit Dey, Niranjan Koirala, Shabnum Shaheen, Nasreddine El Omari, Bahare Salehi, Tamar Goloshvili, Nathália Cristina Cirone Silva, Abdelhakim Bouyahya, Sara Vitalini, Elena M. Varoni, Miquel Martorell, Anna Abdolshahi, Anca Oana Docea, Marcello Iriti, Daniela Calina, Francisco Les, Víctor López, Constantin Caruntu. Cinnamomum Species: Bridging Phytochemistry Knowledge, Pharmacological Properties and Toxicological Safety for Health Benefits. Frontiers in Pharmacology. 2021; 12 ():1.

Chicago/Turabian Style

Javad Sharifi-Rad; Abhijit Dey; Niranjan Koirala; Shabnum Shaheen; Nasreddine El Omari; Bahare Salehi; Tamar Goloshvili; Nathália Cristina Cirone Silva; Abdelhakim Bouyahya; Sara Vitalini; Elena M. Varoni; Miquel Martorell; Anna Abdolshahi; Anca Oana Docea; Marcello Iriti; Daniela Calina; Francisco Les; Víctor López; Constantin Caruntu. 2021. "Cinnamomum Species: Bridging Phytochemistry Knowledge, Pharmacological Properties and Toxicological Safety for Health Benefits." Frontiers in Pharmacology 12, no. : 1.

Journal article
Published: 27 April 2021 in Archives of Endocrinology and Metabolism
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Lorena Mardones; Fanny Petermann-Rocha; Maria Adela Martinez-Sanguinetti; Ana Maria Leiva; Claudia Troncoso-Pantoja; Miquel Martorell; Nicole Lasserre; Natalia Ulloa; Francisco Perez-Bravo; Carlos Celis-Morales; Marcelo Villagran. Genetic variants in the SLC16A11 gene are associated with increased BMI and insulin levels in nondiabetic Chilean population. Archives of Endocrinology and Metabolism 2021, 1 .

AMA Style

Lorena Mardones, Fanny Petermann-Rocha, Maria Adela Martinez-Sanguinetti, Ana Maria Leiva, Claudia Troncoso-Pantoja, Miquel Martorell, Nicole Lasserre, Natalia Ulloa, Francisco Perez-Bravo, Carlos Celis-Morales, Marcelo Villagran. Genetic variants in the SLC16A11 gene are associated with increased BMI and insulin levels in nondiabetic Chilean population. Archives of Endocrinology and Metabolism. 2021; (AHEAD):1.

Chicago/Turabian Style

Lorena Mardones; Fanny Petermann-Rocha; Maria Adela Martinez-Sanguinetti; Ana Maria Leiva; Claudia Troncoso-Pantoja; Miquel Martorell; Nicole Lasserre; Natalia Ulloa; Francisco Perez-Bravo; Carlos Celis-Morales; Marcelo Villagran. 2021. "Genetic variants in the SLC16A11 gene are associated with increased BMI and insulin levels in nondiabetic Chilean population." Archives of Endocrinology and Metabolism , no. AHEAD: 1.

Review
Published: 05 March 2021 in Phytotherapy Research
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Plants of the genus Brassica occupy the top place among vegetables in the world. This genus, which contains a group of six related species of a global economic significance, three of which are diploid: Brassica nigra (L.) K. Koch, Brassica oleracea L., and Brassica rapa L. and three are amphidiploid species: Brassica carinata A. Braun, Brassica juncea (L.) Czern., and Brassica napus L. These varieties are divided into oily, fodder, spice, and vegetable based on their morphological structure, chemical composition, and usefulness of plant organs. The present review provides information about habitat, phytochemical composition, and the bioactive potential of Brassica plants, mainly antioxidant, antimicrobial, anticancer activities, and clinical studies in human. Brassica vegetables are of great economic importance around the world. At present, Brassica plants are grown together with cereals and form the basis of global food supplies. They are distinguished by high nutritional properties from other vegetable plants, such as low fat and protein content and high value of vitamins, fibers along with minerals. In addition, they possess several phenolic compounds and have a unique type of compounds namely glucosinolates that differentiate these crops from other vegetables. These compounds are also responsible for numerous biological activities to the genus Brassica as described in this review.

ACS Style

Bahare Salehi; Cristina Quispe; Monica Butnariu; Ioan Sarac; Ilias Marmouzi; Madhu Kamle; Vijay Tripathi; Pradeep Kumar; Abdelhakim Bouyahya; Esra Capanoglu; Fatma Duygu Ceylan; Laxman Singh; Indra D. Bhatt; Barbara Sawicka; Barbara Krochmal‐Marczak; Dominika Skiba; Meryem El Jemli; Yousra El Jemli; Ericsson Coy‐Barrera; Javad Sharifi‐Rad; Senem Kamiloglu; María De La Luz Cádiz‐Gurrea; Antonio Segura‐Carretero; Manoj Kumar; Miquel Martorell. Phytotherapy and food applications from Brassica genus. Phytotherapy Research 2021, 35, 3590 -3609.

AMA Style

Bahare Salehi, Cristina Quispe, Monica Butnariu, Ioan Sarac, Ilias Marmouzi, Madhu Kamle, Vijay Tripathi, Pradeep Kumar, Abdelhakim Bouyahya, Esra Capanoglu, Fatma Duygu Ceylan, Laxman Singh, Indra D. Bhatt, Barbara Sawicka, Barbara Krochmal‐Marczak, Dominika Skiba, Meryem El Jemli, Yousra El Jemli, Ericsson Coy‐Barrera, Javad Sharifi‐Rad, Senem Kamiloglu, María De La Luz Cádiz‐Gurrea, Antonio Segura‐Carretero, Manoj Kumar, Miquel Martorell. Phytotherapy and food applications from Brassica genus. Phytotherapy Research. 2021; 35 (7):3590-3609.

Chicago/Turabian Style

Bahare Salehi; Cristina Quispe; Monica Butnariu; Ioan Sarac; Ilias Marmouzi; Madhu Kamle; Vijay Tripathi; Pradeep Kumar; Abdelhakim Bouyahya; Esra Capanoglu; Fatma Duygu Ceylan; Laxman Singh; Indra D. Bhatt; Barbara Sawicka; Barbara Krochmal‐Marczak; Dominika Skiba; Meryem El Jemli; Yousra El Jemli; Ericsson Coy‐Barrera; Javad Sharifi‐Rad; Senem Kamiloglu; María De La Luz Cádiz‐Gurrea; Antonio Segura‐Carretero; Manoj Kumar; Miquel Martorell. 2021. "Phytotherapy and food applications from Brassica genus." Phytotherapy Research 35, no. 7: 3590-3609.

Review
Published: 16 February 2021 in Phytotherapy Research
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Oxidative stress is the imbalance between reactive oxygen species (ROS) production, and accumulation and the ability of a biological system to clear these reactive products. This imbalance leads to cell and tissue damage causing several disorders in human body, such as neurodegeneration, metabolic problems, cardiovascular diseases, and cancer. Cucurbitaceae family consists of about 100 genera and 1,000 species of plants including mostly tropical, annual or perennial, monoecious, and dioecious herbs. The plants from Cucurbita species are rich sources of phytochemicals and act as a rich source of antioxidants. The most important phytochemicals present in the cucurbits are cucurbitacins, saponins, carotenoids, phytosterols, and polyphenols. These bioactive phyto‐constituents are responsible for the pharmacological effects including antioxidant, antitumor, antidiabetic, hepatoprotective, antimicrobial, anti‐obesity, diuretic, anti‐ulcer activity, and antigenotoxic. A wide number of in vitro and in vivo studies have ascribed these health‐promoting effects of Cucurbita genus. Results of clinical trials suggest that Cucurbita provides health benefits for diabetic patients, patients with benign prostate hyperplasia, infertile women, postmenopausal women, and stress urinary incontinence in women. The intend of the present review is to focus on the protective role of Cucurbita spp. phytochemicals on oxidative stress‐related disorders on the basis of preclinical and human studies. The review will also give insights on the in vitro and in vivo antioxidant potential of the Cucurbitaceae family as a whole.

ACS Style

Bahare Salehi; Cristina Quispe; Javad Sharifi‐Rad; Lalit Giri; Renu Suyal; Arun K. Jugran; Paolo Zucca; Antonio Rescigno; Stefania Peddio; Otilia Bobiş; Adela Ramona Moise; Gerardo Leyva‐Gómez; María L. Del Prado‐Audelo; Hernán Cortes; Marcello Iriti; Miquel Martorell; Natália Cruz‐Martins; Manoj Kumar; Wissam Zam. Antioxidant potential of family Cucurbitaceae with special emphasis on Cucurbita genus: A key to alleviate oxidative stress‐mediated disorders. Phytotherapy Research 2021, 35, 3533 -3557.

AMA Style

Bahare Salehi, Cristina Quispe, Javad Sharifi‐Rad, Lalit Giri, Renu Suyal, Arun K. Jugran, Paolo Zucca, Antonio Rescigno, Stefania Peddio, Otilia Bobiş, Adela Ramona Moise, Gerardo Leyva‐Gómez, María L. Del Prado‐Audelo, Hernán Cortes, Marcello Iriti, Miquel Martorell, Natália Cruz‐Martins, Manoj Kumar, Wissam Zam. Antioxidant potential of family Cucurbitaceae with special emphasis on Cucurbita genus: A key to alleviate oxidative stress‐mediated disorders. Phytotherapy Research. 2021; 35 (7):3533-3557.

Chicago/Turabian Style

Bahare Salehi; Cristina Quispe; Javad Sharifi‐Rad; Lalit Giri; Renu Suyal; Arun K. Jugran; Paolo Zucca; Antonio Rescigno; Stefania Peddio; Otilia Bobiş; Adela Ramona Moise; Gerardo Leyva‐Gómez; María L. Del Prado‐Audelo; Hernán Cortes; Marcello Iriti; Miquel Martorell; Natália Cruz‐Martins; Manoj Kumar; Wissam Zam. 2021. "Antioxidant potential of family Cucurbitaceae with special emphasis on Cucurbita genus: A key to alleviate oxidative stress‐mediated disorders." Phytotherapy Research 35, no. 7: 3533-3557.

Journal article
Published: 12 February 2021 in Current Pharmaceutical Design
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Mental disorders comprise diverse human pathologies, including depression, bipolar affective disorder, schizophrenia, and dementia that affect millions of people around the world. The causes of mental disorders are unclear, but growing evidence suggests that oxidative stress and the purine/adenosine system play a key role in their development and progression. Xanthine oxidase (XO) is a flavoprotein enzyme essential for the catalysis of the oxidative hydroxylation of purines -hypoxanthine and xanthine- to generate uric acid. As a consequence of the oxidative reaction of XO, reactive oxygen species (ROS) such as superoxide and hydrogen peroxide are produced and, further, contribute to the pathogenesis of mental disorders. Altered XO activity has been associated with free radical-mediated neurotoxicity inducing cell damage and inflammation. Diverse studies reported a direct association between an increased activity of XO and diverse mental diseases including depression or schizophrenia. Small-molecule inhibitors, such as the well-known allopurinol, and dietary flavonoids, can modulate the XO activity and subsequent ROS production. In the present work, we review the available literature on XO inhibition by small molecules and their potential therapeutic application in mental disorders. In addition, we discuss the chemistry and molecular mechanism of XO inhibitors, as well as the use of structure-based and computational methods to design specific inhibitors with the capability of modulating XO activity.

ACS Style

Miquel Martorell; Xavier Lucas; Pedro Alarcón-Zapata; Xavier Capó; Maria Magdalena Quetglas-Llabrés; Silvia Tejada; Antoni Sureda. Targeting Xanthine Oxidase by Natural Products as a Therapeutic Approach for Mental Disorders. Current Pharmaceutical Design 2021, 27, 367 -382.

AMA Style

Miquel Martorell, Xavier Lucas, Pedro Alarcón-Zapata, Xavier Capó, Maria Magdalena Quetglas-Llabrés, Silvia Tejada, Antoni Sureda. Targeting Xanthine Oxidase by Natural Products as a Therapeutic Approach for Mental Disorders. Current Pharmaceutical Design. 2021; 27 (3):367-382.

Chicago/Turabian Style

Miquel Martorell; Xavier Lucas; Pedro Alarcón-Zapata; Xavier Capó; Maria Magdalena Quetglas-Llabrés; Silvia Tejada; Antoni Sureda. 2021. "Targeting Xanthine Oxidase by Natural Products as a Therapeutic Approach for Mental Disorders." Current Pharmaceutical Design 27, no. 3: 367-382.

Review
Published: 01 February 2021 in Seminars in Cancer Biology
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The conventional therapies for cancer have a major concern of poor accessibility to tumor tissues. Furthermore, the requirement of higher doses and non-selective nature of therapeutic are associated with a range of adverse drug reactions (ADRs). However, flavonoids are documented to be effective against various types of cancer, but they are not evaluated for their safety profile and tumor site-specific action. Low solubility, rapid metabolism and poor absorption of dietary flavonoids in gastrointestinal tract hinder their pharmacological potential. Some studies have also suggested that flavonoids may act as pro-oxidant in some cases and may interact with other therapeutic agents, especially through biotransformation. Nanocarriers can alter pharmacokinetics and pharmacodynamic profile of incorporating drug. Moreover, nanocarriers are designed for targeted drug delivery, improving the bioavailability of poorly water-soluble drugs, delivery of macromolecules to site of action within the cell, combining therapeutic agents with imaging techniques which may visualize the site of drug delivery and co-delivery of two or more drugs. Combining two or more anti-cancer agents can reduce ADRs and nanotechnology played a pivotal role in this regard. In vitro and in vivo studies have shown the potential of flavonoids nano-formulations, especially quercetin, naringenin, apigenin, catechins and fisetin in the prevention and treatment of several types of cancer. Similarly, clinical trials have been conducted using flavonoids alone or in combination, however, the nano-formulations effect still needs to be elucidated. This review focuses on the impact of flavonoids nano-formulations on the improvement of their bioavailability, therapeutic and safety profile and will open new insights in the field of drug discovery for cancer therapeutics.

ACS Style

Haroon Khan; Hammad Ullah; Miquel Martorell; Susana Esteban Valdes; Tarun Belwal; Silvia Tejada; Antoni Sureda; Mohammad Amjad Kamal. Flavonoids nanoparticles in cancer: Treatment, prevention and clinical prospects. Seminars in Cancer Biology 2021, 69, 200 -211.

AMA Style

Haroon Khan, Hammad Ullah, Miquel Martorell, Susana Esteban Valdes, Tarun Belwal, Silvia Tejada, Antoni Sureda, Mohammad Amjad Kamal. Flavonoids nanoparticles in cancer: Treatment, prevention and clinical prospects. Seminars in Cancer Biology. 2021; 69 ():200-211.

Chicago/Turabian Style

Haroon Khan; Hammad Ullah; Miquel Martorell; Susana Esteban Valdes; Tarun Belwal; Silvia Tejada; Antoni Sureda; Mohammad Amjad Kamal. 2021. "Flavonoids nanoparticles in cancer: Treatment, prevention and clinical prospects." Seminars in Cancer Biology 69, no. : 200-211.

Review
Published: 25 January 2021 in Critical Reviews in Food Science and Nutrition
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Flavonoids are common in the plant kingdom and many of them have shown a wide spectrum of bioactive properties. Hesperetin (Hst), the aglycone form of hesperidin, is a great example, and is the most abundant flavonoid found in Citrus plants. This review aims to provide an overview on the in vitro, in vivo and clinical studies reporting the Hst pharmacological effects and to discuss the bioavailability-related issues. Preclinical studies have shown promising effects on cancer, cardiovascular diseases, carbohydrate dysregulation, bone health, and other pathologies. Clinical studies have supported the Hst promissory effects as cardioprotective and neuroprotective agent. However, further well-designed clinical trials are needed to address the other Hst effects observed in preclinical trials, as well as to a more in-depth understanding of its safety profile.

ACS Style

Bahare Salehi; Natália Cruz-Martins; Monica Butnariu; Ioan Sarac; Iulia-Cristina Bagiu; Shahira M. Ezzat; Jinfan Wang; Aaron Koay; Helen Sheridan; Charles Oluwaseun Adetunji; Prabhakar Semwal; Mauricio Schoebitz; Miquel Martorell; Javad Sharifi-Rad. Hesperetin’s health potential: moving from preclinical to clinical evidence and bioavailability issues, to upcoming strategies to overcome current limitations. Critical Reviews in Food Science and Nutrition 2021, 1 -16.

AMA Style

Bahare Salehi, Natália Cruz-Martins, Monica Butnariu, Ioan Sarac, Iulia-Cristina Bagiu, Shahira M. Ezzat, Jinfan Wang, Aaron Koay, Helen Sheridan, Charles Oluwaseun Adetunji, Prabhakar Semwal, Mauricio Schoebitz, Miquel Martorell, Javad Sharifi-Rad. Hesperetin’s health potential: moving from preclinical to clinical evidence and bioavailability issues, to upcoming strategies to overcome current limitations. Critical Reviews in Food Science and Nutrition. 2021; ():1-16.

Chicago/Turabian Style

Bahare Salehi; Natália Cruz-Martins; Monica Butnariu; Ioan Sarac; Iulia-Cristina Bagiu; Shahira M. Ezzat; Jinfan Wang; Aaron Koay; Helen Sheridan; Charles Oluwaseun Adetunji; Prabhakar Semwal; Mauricio Schoebitz; Miquel Martorell; Javad Sharifi-Rad. 2021. "Hesperetin’s health potential: moving from preclinical to clinical evidence and bioavailability issues, to upcoming strategies to overcome current limitations." Critical Reviews in Food Science and Nutrition , no. : 1-16.

Review
Published: 16 December 2020 in Phytotherapy Research
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Astragalus L. is widely distributed throughout the temperate regions of Europe, Asia, and North America. The genus is widely used in folk medicine and in dietary supplements, as well as in cosmetics, teas, coffee, vegetable gums, and as forage for animals. The major phytoconstituents of Astragalus species with beneficial properties are saponins, flavonoids, and polysaccharides. Astragalus extracts and their isolated components exhibited promising in vitro and in vivo biological activities, including antiaging, antiinfective, cytoprotective, antiinflammatory, antioxidant, antitumor, antidiabesity, and immune‐enhancing properties. Considering their proven therapeutic potential, the aim of this work is to give a comprehensive summary of the Astragalus spp. and their active components, in an attempt to provide new insight for further clinical development of these xenobiotics. This is the first review that briefly describes their ethnopharmacology, composition, biological, and toxicological properties.

ACS Style

Bahare Salehi; Joara Nályda Pereira Carneiro; Janaína Esmeraldo Rocha; Henrique Douglas Melo Coutinho; Maria Flaviana Bezerra Morais Braga; Javad Sharifi‐Rad; Prabhakar Semwal; Sakshi Painuli; Laila Moujir Moujir; Victoria De Zarate Machado; Shriyaa Janakiram; Nanjangud Venkatesh Anil Kumar; Miquel Martorell; Natalia Cruz‐Martins; Marc El Beyrouthy; Carmen Sadaka. Astragalus species: Insights on its chemical composition toward pharmacological applications. Phytotherapy Research 2020, 35, 2445 -2476.

AMA Style

Bahare Salehi, Joara Nályda Pereira Carneiro, Janaína Esmeraldo Rocha, Henrique Douglas Melo Coutinho, Maria Flaviana Bezerra Morais Braga, Javad Sharifi‐Rad, Prabhakar Semwal, Sakshi Painuli, Laila Moujir Moujir, Victoria De Zarate Machado, Shriyaa Janakiram, Nanjangud Venkatesh Anil Kumar, Miquel Martorell, Natalia Cruz‐Martins, Marc El Beyrouthy, Carmen Sadaka. Astragalus species: Insights on its chemical composition toward pharmacological applications. Phytotherapy Research. 2020; 35 (5):2445-2476.

Chicago/Turabian Style

Bahare Salehi; Joara Nályda Pereira Carneiro; Janaína Esmeraldo Rocha; Henrique Douglas Melo Coutinho; Maria Flaviana Bezerra Morais Braga; Javad Sharifi‐Rad; Prabhakar Semwal; Sakshi Painuli; Laila Moujir Moujir; Victoria De Zarate Machado; Shriyaa Janakiram; Nanjangud Venkatesh Anil Kumar; Miquel Martorell; Natalia Cruz‐Martins; Marc El Beyrouthy; Carmen Sadaka. 2020. "Astragalus species: Insights on its chemical composition toward pharmacological applications." Phytotherapy Research 35, no. 5: 2445-2476.

Review
Published: 22 October 2020 in Frontiers in Pharmacology
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Analysis of the most relevant studies on the pharmacological properties and molecular mechanisms of psoralidin, a bioactive compound from the seeds of Cullen corylifolium (L.) Medik. confirmed its complex therapeutic potential. In the last years, the interest of the scientific community regarding psoralidin increased, especially after the discovery of its benefits in estrogen-related diseases and as a chemopreventive agent. Growing preclinical pieces of evidence indicate that psoralidin has anticancer, antiosteoporotic, anti-inflammatory, anti-vitiligo, antibacterial, antiviral, and antidepressant-like effects. Here, we provide a comprehensive and critical review of psoralidin on its bioavailability, pharmacological activities with focus on molecular mechanisms and cell signaling pathways. In this review, we conducted literature research on the PubMed database using the following keywords: “Psoralidin” or “therapeutic effects” or “biological activity” or “Cullen corylifolium” in order to identify relevant studies regarding PSO bioavailability and mechanisms of therapeutic effects in different diseases based on preclinical, experimental studies. In the light of psoralidin beneficial actions for human health, this paper gathers complete information on its pharmacotherapeutic effects and opens new natural therapeutic perspectives in chronic diseases.

ACS Style

Javad Sharifi-Rad; Senem Kamiloglu; Balakyz Yeskaliyeva; Ahmet Beyatli; Mary Angelia Alfred; Bahare Salehi; Daniela Calina; Anca Oana Docea; Muhammad Imran; Nanjangud Venaktesh Anil Kumar; Maria Eugenia Romero-Román; Alfred Maroyi; Miquel Martorell. Pharmacological Activities of Psoralidin: A Comprehensive Review of the Molecular Mechanisms of Action. Frontiers in Pharmacology 2020, 11, 571459 .

AMA Style

Javad Sharifi-Rad, Senem Kamiloglu, Balakyz Yeskaliyeva, Ahmet Beyatli, Mary Angelia Alfred, Bahare Salehi, Daniela Calina, Anca Oana Docea, Muhammad Imran, Nanjangud Venaktesh Anil Kumar, Maria Eugenia Romero-Román, Alfred Maroyi, Miquel Martorell. Pharmacological Activities of Psoralidin: A Comprehensive Review of the Molecular Mechanisms of Action. Frontiers in Pharmacology. 2020; 11 ():571459.

Chicago/Turabian Style

Javad Sharifi-Rad; Senem Kamiloglu; Balakyz Yeskaliyeva; Ahmet Beyatli; Mary Angelia Alfred; Bahare Salehi; Daniela Calina; Anca Oana Docea; Muhammad Imran; Nanjangud Venaktesh Anil Kumar; Maria Eugenia Romero-Román; Alfred Maroyi; Miquel Martorell. 2020. "Pharmacological Activities of Psoralidin: A Comprehensive Review of the Molecular Mechanisms of Action." Frontiers in Pharmacology 11, no. : 571459.