Introduction: Intradural extramedullary and intramedullary spinal tumors are rare, complex to treat, and require advanced surgical techniques. Ultrasonic aspirators, commonly used for tumor removal, can cause sensory and motor deficits, including loss of motor evoked potentials (MEPs). This study aims to evaluate the safety and efficacy of ultrasonic aspirators in intramedullary tumor surgery using a swine model, comparing different systems and techniques. Methods: Ten pigs underwent D1-D3 laminectomy and myelotomy, with adipose tissue simulating a tumor. The ultrasonic aspirators were tested under varying conditions (fragmentation power, suction, application time, and vibration mode). The primary endpoint is to evaluate the impact of the chosen variables on motor function damage. The secondary endpoints are histological evaluation of the type of damage caused by ultrasound aspirators and the effect of steroid drugs on MEPs’ impairment recovery. Results: Ultrasound aspirators can cause a significant MEP signal reduction when used in continuous mode, with fragmentation power >30 for more than 2 min (p < 0.001). Suction does not affect MEPs. When used in alternating/pulsatile mode, fragmentation power and application time do not affect MEPs. The two-way ANOVA analysis on the interaction between fragmentation power and application time in continuous mode did not demonstrate a significant interaction (p = 0.155). Time alone does not affect motor damage (p = 0.873). Betamethasone can restore MEPs’ signal after damage if administered immediately. Conclusions: Using ultrasonic aspirators in an animal model of intramedullary tumor surgery is safe. The main factor that resulted in the responsibility of motor function impairment is the fragmentation power.

Introduction: Plasminogen deficiency is a congenital autosomal recessive disorder. Ligneous conjunctivitis is pathognomonic for the disease; however, hydrocephalus is a rare complication. Case Presentation: A neonate with prenatal diagnosis of hydrocephalus associated with Dandy-Walker syndrome was sent to our observation. Surgery was followed by multiple shunt malfunctions in the early postoperative period. An ophthalmological evaluation suggested the diagnosis of ligneous conjunctivitis. Laboratory tests lead to the diagnosis of a systemic PLGD. The disease caused the formation of multiple membranes, which prevented the proper functioning of the ventricular shunts. We started an alternated treatment with plasma transfusions and plasma-derived human plasminogen. This has allowed the control of the complications related to the treatment of the hydrocephalus. Discussion: Ligneous conjunctivitis was pivotal in the diagnosis of pathology. It is currently difficult to get sufficient doses of plasma-derived human plasminogen for ev administration, considering that it is still not officially authorized in Europe.