Nutrients such as ω-3 fatty acids including fish oil components eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) suppress the growth and promote apoptosis of tumor cells, improve immune function and reduce the effects of systemic inflammatory response syndrome. We sought to investigate the effect of ω-3 fish oil fat emulsion-based parenteral nutrition (PN) on nutritional state, immune function, inflammatory reaction, expression of tumor factors and complication incidence in patients after surgical resection of gastric cancer.

Organoids, three-dimensional (3D) in vitro models derived from patient tissues or stem cells, have developed into transformative tools in oncology by recapitulating the structural, genetic, and functional heterogeneity of native tumors. move from fundamental research to clinical application. This review outlines key applications of organoids in cancer research, including tumor modeling, high-throughput drug screening, immunotherapy evaluation, and dissection of metastatic mechanisms. Case studies of various cancers highlight their ability to preserve patient-specific genomic alterations and predict treatment outcomes. Although challenges remain in many areas, multidisciplinary advances in bioengineering and multi-omics integration are expected to overcome these limitations, demonstrating the unprecedented potential of this technology.

Objective: To investigate the therapeutic effect and adverse drug reactions(ADRs) of neoadjuvant chemotherapy combined with docetaxel,oxaliplatin and capecitabine(DOX regimen) in the treatment of advanced gastric cancer.Methods: One hundred and eighty-six patients with advanced gastric cancer in Department of Gastrointestinal Surgery,Changzheng Hospital,Second Military Medical University from 2008-06-01 to 2011-05-31 received neoadjuvant chemotherapy.Neoadjuvant chemotherapy regimen was as follows:75 mg/m2 docetaxel(iv gtt,on day 1),130 mg/m2 oxaliplatin(iv gtt,on day 2),1 000 mg/m2 capecitabine(bid,po,on days 1-14) with 3 weeks as one treatment course,totalling 2-3 courses.And the patients received surgery,2-3 weeks after termination of chemotherapy.Results: Total response rate was 67.8%,complete response rate was 3.8%(7 patients),partial response rate was 64.0%(119 patients).Total resection rate was 81.5%,R0 resection rate was 80.4%.Main ADRs were myelosuppression,nausea and vomiting.Conclusion: Overall curative resection rate was increased in patients with advanced gastric cancer,after neoadjuvant chemotherapy with docetaxel,oxaliplatin and capecitabine.The ADRs rate of neoadjuvant chemotherapy was within acceptable range.

Stomach adenocarcinoma (STAD) remains a significant threat to human health. This study sought to discover clinically relevant biomarkers for STAD by integrating bioinformatics analysis and in vitro experimental methods. We utilized the GSE64951 dataset to screen for differentially expressed genes (DEGs), which were then subjected to weighted gene co-expression network analysis (WGCNA). Candidate modules were subjected to Molecular Complex Detection (MCODE) analysis to extract key genes. Survival analysis and immune infiltration analysis were conducted to identify hub genes associated with STAD prognosis. Among them, cytochrome c oxidase subunit 7 C (COX7C) was selected for further investigation. Its expression levels in normal versus tumor tissues were compared, and its diagnostic performance was assessed via receiver operating characteristic (ROC) curve analysis. Functional experiments, including COX7C overexpression and knockdown, were performed in MGC803 cells to evaluate its effects on viability, apoptosis, migration, and invasion. WGCNA identified multiple gene modules, among which the blue and turquoise modules showed the strongest correlations with clinical traits and were selected for further analysis. MCODE analysis identified 11 key genes. COX7C was identified as hub gene, and its prognostic signature demonstrated robust predictive power. Gene Set Enrichment Analysis (GSEA) indicated that COX7C was significantly involved in pathways such as amino acid metabolism and non - alcoholic fatty liver disease. Notably, COX7C mRNA expression was significantly downregulated in STAD tissues (AUC = 0.7253, P = 0.0032). Functional experiments demonstrated that overexpression of COX7C significantly inhibited cell viability, promoted apoptosis, and reduced cell migration and invasion. Conversely, knockdown of COX7C led to opposite effects. COX7C functions as a tumor suppressor and a potential prognostic biomarker in STAD. These findings provide new insights into STAD pathogenesis and suggest COX7C as a promising target for improving diagnostic and therapeutic strategies.