This page has only limited features, please log in for full access.

Dr. Sören Möller
Open Patient data Explorative Network, Department of Clinical Research, University of Southern Denmark, Odense, Denmark

Basic Info


Research Keywords & Expertise

0 Biostatistics
0 Probability Theory
0 Epidemiological Methods
0 Risk prediction scores
0 Unusual bias sources

Honors and Awards

The user has no records in this section


Career Timeline

The user has no records in this section.


Short Biography

The user biography is not available.
Following
Followers
Co Authors
The list of users this user is following is empty.
Following: 0 users

Feed

Journal article
Published: 27 August 2021 in COVID
Reads 0
Downloads 0

In general, governments and health authorities have taken precautions during the COVID-19 pandemic to reduce the viral spread and protect vulnerable citizens. Patients with multiple myeloma (MM) have an increased risk of being infected with COVID-19 and developing a fatal course due to the related immunodeficiency. We investigated how Danish patients with MM reported their quality of life (QoL) pre-COVID and during COVID, in an ongoing longitudinal QoL survey. The responses given during the first and second wave of the COVID-19 pandemic were pooled, analyzed and compared to the same period the year before. We hypothesized that locking down the society would have caused deteriorated QoL and that patients living alone and those under the age of 65 would be particularly affected by the situation. Surprisingly, our study showed the opposite. Statistically significant and clinically relevant differences were primarily found during the first lock down and represented reduced fatigue, improved role functioning, decreased insomnia and improved physical health summaries in patients below 65 years of age. These results indicate that Danish patients with MM might have felt protected and safe by COVID restrictions. Otherwise, the questionaries used in QoL-MM survey may not have been able to capture the impact of the COVID-19 pandemic. Importantly, this indicates that QoL survey data obtained in clinical studies, in countries with highly developed health-care systems using standard questionnaires during the pandemic, allow room for interpretation without being adjusted for the impacts of the pandemic.

ACS Style

Louise Redder; Sören Möller; Anna Thit Johnsen; Mary Jarden; Christen Lykkegaard Andersen; Bo Amdi Jensen; Henrik Frederiksen; Henrik Gregersen; Anja Klostergaard; Morten Saaby Steffensen; Per Trøllund Pedersen; Maja Hinge; Mikael Frederiksen; Carsten Helleberg; Anne Kærsgaard Mylin; Niels Abildgaard; Lene Kongsgaard Nielsen. Quality of Life in Danish Patients with Multiple Myeloma during the COVID-19 Pandemic. COVID 2021, 1, 303 -314.

AMA Style

Louise Redder, Sören Möller, Anna Thit Johnsen, Mary Jarden, Christen Lykkegaard Andersen, Bo Amdi Jensen, Henrik Frederiksen, Henrik Gregersen, Anja Klostergaard, Morten Saaby Steffensen, Per Trøllund Pedersen, Maja Hinge, Mikael Frederiksen, Carsten Helleberg, Anne Kærsgaard Mylin, Niels Abildgaard, Lene Kongsgaard Nielsen. Quality of Life in Danish Patients with Multiple Myeloma during the COVID-19 Pandemic. COVID. 2021; 1 (1):303-314.

Chicago/Turabian Style

Louise Redder; Sören Möller; Anna Thit Johnsen; Mary Jarden; Christen Lykkegaard Andersen; Bo Amdi Jensen; Henrik Frederiksen; Henrik Gregersen; Anja Klostergaard; Morten Saaby Steffensen; Per Trøllund Pedersen; Maja Hinge; Mikael Frederiksen; Carsten Helleberg; Anne Kærsgaard Mylin; Niels Abildgaard; Lene Kongsgaard Nielsen. 2021. "Quality of Life in Danish Patients with Multiple Myeloma during the COVID-19 Pandemic." COVID 1, no. 1: 303-314.

Correspondence
Published: 11 August 2021 in Vaccine
Reads 0
Downloads 0
ACS Style

Sören Möller; Sebastian Nielsen. Letter to the editor. Vaccine 2021, 1 .

AMA Style

Sören Möller, Sebastian Nielsen. Letter to the editor. Vaccine. 2021; ():1.

Chicago/Turabian Style

Sören Möller; Sebastian Nielsen. 2021. "Letter to the editor." Vaccine , no. : 1.

Article
Published: 05 August 2021 in Scientific Reports
Reads 0
Downloads 0

Bedside detection and early treatment of lasting cerebral ischemia may improve outcome after out-of-hospital cardiac arrest (OHCA). This feasibility study explores the possibilities to use microdialysis (MD) for continuous monitoring of cerebral energy metabolism by analyzing the draining cerebral venous blood. Eighteen comatose patients were continuously monitored with jugular bulb and radial artery (reference) MD following resuscitation. Median time from cardiac arrest to MD was 300 min (IQR 230–390) with median monitoring time 60 h (IQR 40–81). The lactate/pyruvate ratio in cerebral venous blood was increased during the first 20 h after OHCA, and significant differences in time-averaged mean MD metabolites between jugular venous and artery measurements, were documented (p < 0.02). In patients with unfavorable outcome (72%), cerebral venous lactate and pyruvate levels remained elevated during the study period. In conclusion, the study indicates that jugular bulb microdialysis (JBM) is feasible and safe. Biochemical signs of lasting ischemia and mitochondrial dysfunction are frequent and associated with unfavorable outcome. The technique may be used in comatose OHCA patients to monitor biochemical variables reflecting ongoing brain damage and support individualized treatment early after resuscitation.

ACS Style

Simon Mölström; Troels Halfeld Nielsen; Carl H. Nordström; Axel Forsse; Sören Möller; Sören Venö; Dmitry Mamaev; Tomas Tencer; Henrik Schmidt; Palle Toft. Bedside microdialysis for detection of early brain injury after out-of-hospital cardiac arrest. Scientific Reports 2021, 11, 1 -11.

AMA Style

Simon Mölström, Troels Halfeld Nielsen, Carl H. Nordström, Axel Forsse, Sören Möller, Sören Venö, Dmitry Mamaev, Tomas Tencer, Henrik Schmidt, Palle Toft. Bedside microdialysis for detection of early brain injury after out-of-hospital cardiac arrest. Scientific Reports. 2021; 11 (1):1-11.

Chicago/Turabian Style

Simon Mölström; Troels Halfeld Nielsen; Carl H. Nordström; Axel Forsse; Sören Möller; Sören Venö; Dmitry Mamaev; Tomas Tencer; Henrik Schmidt; Palle Toft. 2021. "Bedside microdialysis for detection of early brain injury after out-of-hospital cardiac arrest." Scientific Reports 11, no. 1: 1-11.

Original research article
Published: 29 July 2021 in Acta Obstetricia et Gynecologica Scandinavica
Reads 0
Downloads 0

Introduction The aim of the study was to investigate whether robotic-assisted surgery is associated with lower incremental resource use amongst obese patients relative to non-obese patients after a Danish nationwide adoption of robotic-assisted surgery in women with early-stage endometrial cancer. This is a population-based cohort study based on registers and clinical data. Material and methods All women who underwent surgery (robotic, laparoscopic, and laparotomy) from 2008 to 2015 were included and divided according to body mass index (<30 and ≥30). Robotic-assisted surgery was gradually introduced in Denmark (2008-2013). We compared resource use post-surgery in obese vs non-obese women who underwent surgery before and after a nationwide adoption of robotic-assisted surgery. The key exposure variable was exposure to robotic-assisted surgery. Clinical and sociodemographic data was linked with national register data to determine costs and bed days 12 months before and after surgery applying difference-in-difference analyses. Results In total, 3934 women were included. The adoption of robotic-assisted surgery did not demonstrate statistically significant implications for total costs among obese women (€3417; 95% confidence interval [CI] -€854 to €7688, P = .117). Further, for obese women, a statistically significant reduction in bed days related to the index hospitalization was demonstrated (-1.9 bed days; CI -3.6 to -0.2, P = .025). For non-obese women, the adoption of robotic-assisted surgery was, however, associated with statistically significant total costs increments of €9333 (95% CI €3729 to €14936, P = .001) and no reduction in bed days related to the index hospitalization was observed (+0.9 bed days; 95% CI -0.6 to 2.3, P = .242). Conclusions The national investment in robotic-assisted surgery for endometrial cancer seems to have more modest cost implications post-surgery for obese women. This may be partly driven by a significant reduction in bed days related to the index hospitalization among obese women, as well as reductions in subsequent hospitalizations.

ACS Style

Malene Korsholm; Dorte Gyrd‐Hansen; Ole Mogensen; Sören Möller; Siv L. Joergensen; Pernille T. Jensen. Post robotic investment: Cost consequences and impact on length of stay for obese women with endometrial cancer. Acta Obstetricia et Gynecologica Scandinavica 2021, 1 .

AMA Style

Malene Korsholm, Dorte Gyrd‐Hansen, Ole Mogensen, Sören Möller, Siv L. Joergensen, Pernille T. Jensen. Post robotic investment: Cost consequences and impact on length of stay for obese women with endometrial cancer. Acta Obstetricia et Gynecologica Scandinavica. 2021; ():1.

Chicago/Turabian Style

Malene Korsholm; Dorte Gyrd‐Hansen; Ole Mogensen; Sören Möller; Siv L. Joergensen; Pernille T. Jensen. 2021. "Post robotic investment: Cost consequences and impact on length of stay for obese women with endometrial cancer." Acta Obstetricia et Gynecologica Scandinavica , no. : 1.

Oncology
Published: 02 July 2021 in PLOS ONE
Reads 0
Downloads 0

Background Although research findings consistently find poor communication about medical procedures to be a key predictor of patient complaints, compensation claims, and malpractice lawsuits (“complaints”), there is insufficient evidence to determine if greater patient involvement could actually affect the inclination to complain. Objectives We conducted an experimental case vignette survey that explores whether greater patient involvement in decision-making is likely to influence the intention to complain given different decisions and consequences. Methods Randomized, national case vignette survey with various levels of patient involvement, decisions, and outcomes in a representative Danish sample of men. We used prostate specific antigen (PSA) screening in men aged 45 to 70 years as the intervention illustrated in 30 different versions of a mock clinical encounter. Versions differed in the amount of patient involvement, the decision made (PSA test or no PSA test), and the clinical outcomes (no cancer detected, detection of treatable cancer, and detection of non-treatable cancer). We measured respondents’ inclination to complain about care in response to the scenarios on a 5-point Likert scale (from 1: very unlikely to 5: very likely). Results The response rate was 30% (6,756 of 22,288). Across all scenarios, the likelihood of complaint increased if the clinical outcome was poor (untreatable cancer). Compared with scenarios that involved shared decision-making (SDM), neutral information, or nudging in favor of screening, the urge to complain increased if the patient was excluded from decision-making or if the doctor had nudged the patient to decline screening (mean Likert differences .12 to .16, p < .001). With neutral involvement or nudging in favor of intervention, the desire to complain depended highly on the decision reached and on the patient’s course. This dependence was smaller with SDM. Conclusions Greater patient involvement in decision-making appears to be associated with less intention to complain about health care, with SDM resulting in the greatest reduction in complaint likelihood.

ACS Style

Søren Birkeland; Marie Bismark; Michael J. Barry; Sören Möller. Does greater patient involvement in healthcare decision-making affect malpractice complaints? A large case vignette survey. PLOS ONE 2021, 16, e0254052 .

AMA Style

Søren Birkeland, Marie Bismark, Michael J. Barry, Sören Möller. Does greater patient involvement in healthcare decision-making affect malpractice complaints? A large case vignette survey. PLOS ONE. 2021; 16 (7):e0254052.

Chicago/Turabian Style

Søren Birkeland; Marie Bismark; Michael J. Barry; Sören Möller. 2021. "Does greater patient involvement in healthcare decision-making affect malpractice complaints? A large case vignette survey." PLOS ONE 16, no. 7: e0254052.

Brief report
Published: 01 July 2021 in JAMA Cardiology
Reads 0
Downloads 0

Importance Sodium-glucose cotransporter-2 inhibitors (SGLT2i) improve outcomes in patients with heart failure and a reduced ejection fraction (HFrEF). The association with cardiac remodeling has not been investigated. Objective To investigate the outcome of the SGLT2i empagliflozin, compared with placebo, on cardiac remodeling in patients with HFrEF. Design, Setting, and Participants This exploratory post hoc analysis included participants with stable HFrEF and ejection fractions of 40% or less, who were randomly enrolled in an investigator-initiated, multicenter, double-blind, placebo-controlled randomized clinical trial in Denmark. Enrollment commenced on June 29, 2017, and continued through September 10, 2019, with the last participant follow-up on December 20, 2019. Interventions Randomization (1:1) to empagliflozin (10 mg once daily) or matching placebo in addition to recommended heart failure therapy for 12 weeks. Main Outcomes and Measures Efficacy measures were changes from baseline to week 12 in left ventricular end-systolic and end-diastolic volume indexes, left atrial volume index, and left ventricular ejection fraction adjusted for age, sex, type 2 diabetes, and atrial fibrillation. Secondary efficacy measures included changes in left ventricular mass index, global longitudinal strain, and relative wall thickness. Results A total of 190 patients were randomized (95 each receiving empagliflozin and placebo), with a mean (SD) age of 64 (11) years; 162 were men (85.3%), 97 (51.1%) had ischemic HFrEF, 24 (12.6%) had type 2 diabetes, and the mean (SD) latest recorded left ventricular ejection fraction was 29% (8%). Of the 190, 186 completed the study. Empagliflozin significantly reduced left ventricular end-systolic volume index (−4.3 [95% CI, −8.5 to −0.1] mL/m2;P = .04), left ventricular end-diastolic volume index (−5.5 [95% CI, −10.6 to −0.4] mL/m2;P = .03), and left atrial volume index (−2.5 [95% CI, −4.8 to −0.1] mL/m2;P = .04) compared with placebo at 12 weeks’ follow-up, with no change in left ventricular ejection fraction (1.2% [95% CI, −1.2% to 3.6%];P = .32). These findings were consistent across subgroups. Of secondary efficacy measures, left ventricular mass index was significantly reduced by empagliflozin (−9.0 [95% CI, −17.2 to −0.8] g/m2;P = .03). Conclusions and Relevance In this small, randomized, short-term study, empagliflozin was associated with modest reductions in left ventricular and left atrial volumes with no association with ejection fraction. Effects beyond 12 weeks of SGLT2i use require further study. Trial Registration ClinicalTrials.gov Identifier:NCT03198585

ACS Style

Massar Omar; Jesper Jensen; Mulham Ali; Peter H. Frederiksen; Caroline Kistorp; Lars Videbæk; Mikael Kjær Poulsen; Christian D. Tuxen; Sören Möller; Finn Gustafsson; Lars Køber; Morten Schou; Jacob Eifer Møller. Associations of Empagliflozin With Left Ventricular Volumes, Mass, and Function in Patients With Heart Failure and Reduced Ejection Fraction. JAMA Cardiology 2021, 6, 836 .

AMA Style

Massar Omar, Jesper Jensen, Mulham Ali, Peter H. Frederiksen, Caroline Kistorp, Lars Videbæk, Mikael Kjær Poulsen, Christian D. Tuxen, Sören Möller, Finn Gustafsson, Lars Køber, Morten Schou, Jacob Eifer Møller. Associations of Empagliflozin With Left Ventricular Volumes, Mass, and Function in Patients With Heart Failure and Reduced Ejection Fraction. JAMA Cardiology. 2021; 6 (7):836.

Chicago/Turabian Style

Massar Omar; Jesper Jensen; Mulham Ali; Peter H. Frederiksen; Caroline Kistorp; Lars Videbæk; Mikael Kjær Poulsen; Christian D. Tuxen; Sören Möller; Finn Gustafsson; Lars Køber; Morten Schou; Jacob Eifer Møller. 2021. "Associations of Empagliflozin With Left Ventricular Volumes, Mass, and Function in Patients With Heart Failure and Reduced Ejection Fraction." JAMA Cardiology 6, no. 7: 836.

Original research
Published: 18 June 2021 in International Journal of Gynecologic Cancer
Reads 0
Downloads 0

Background The vast majority of patients with advanced ovarian cancer experience disease recurrence after primary treatment. Objective To explore the diagnostic accuracy of repeated measurement of patient-reported outcomes and quality-of-life scores in relation to ovarian cancer recurrence. Methods Patients with ovarian cancer were recruited to the PROMova study by the end of their primary treatment at eight centers in Denmark. The purpose of the PROMova study was to explore the applicability of repeated use of patient-reported outcomes, which consisted of the European Organization for Research and Treatment of Cancer generic questionnaire and the ovarian specific questionnaire. The patient-reported outcomes were completed 3, 6, 9, 12, and 15 months after enrollment or until recurrence. The 3-month interval between completions was the period in which recurrence was assessed. Imaging and the biomarker CA125 were used as reference modality for recurrence. Mixed effects logistic regression was used to investigate the association between mean patient-reported outcome scores and recurrence. Receiver operating curves were used to establish cut-off scores. The diagnostic accuracy of patient-reported outcomes, including sensitivity, specificity, and positive and negative predictive values was estimated based on the Youden index. For combined scales, diagnostic accuracy was investigated based on multivariate analysis. Results The analysis included 196 patients with an overall recurrence rate of 50.5% and an overall mean time to recurrence of 302 days. With imaging as reference, patients with recurrence reported significantly lower global health, worse physical functioning, and more abdominal symptoms preceding recurrence. With CA125 as reference, global health, physical and emotional functioning were impaired. Despite the worsening of a number of symptoms prior to recurrence whichever reference modality was applied, the patient-reported outcome scores did not provide adequate diagnostic accuracy. Conclusion Repeated use of patient-reported outcomes during surveillance of ovarian cancer was not of diagnostic value. Future efforts should be directed at improving the administration of patient-reported outcomes as well as exploring the potential of using these outcomes as an indicator of clinical relevance.

ACS Style

Anette Stolberg Kargo; Pernille Tine Jensen; Kristina Lindemann; Niels Henrik Hjøllund; Gabor Istvan Liposits; Nicoline Raaschou-Jensen; Bettina Mølri Knudsen; Sören Möller; Dorte Gilså Hansen; Karina Dahl Steffensen. Association of patient-reported outcomes and ovarian cancer recurrence. International Journal of Gynecologic Cancer 2021, 1 .

AMA Style

Anette Stolberg Kargo, Pernille Tine Jensen, Kristina Lindemann, Niels Henrik Hjøllund, Gabor Istvan Liposits, Nicoline Raaschou-Jensen, Bettina Mølri Knudsen, Sören Möller, Dorte Gilså Hansen, Karina Dahl Steffensen. Association of patient-reported outcomes and ovarian cancer recurrence. International Journal of Gynecologic Cancer. 2021; ():1.

Chicago/Turabian Style

Anette Stolberg Kargo; Pernille Tine Jensen; Kristina Lindemann; Niels Henrik Hjøllund; Gabor Istvan Liposits; Nicoline Raaschou-Jensen; Bettina Mølri Knudsen; Sören Möller; Dorte Gilså Hansen; Karina Dahl Steffensen. 2021. "Association of patient-reported outcomes and ovarian cancer recurrence." International Journal of Gynecologic Cancer , no. : 1.

Original articles
Published: 06 June 2021 in Journal of Cardiovascular Electrophysiology
Reads 0
Downloads 0

Background Patients receiving an implantable cardioverter defibrillator (ICD) generally adapt well to living with their device, but we know little about the prevalence of patients' body image concerns (BICs) postimplant. Methods The objectives were to evaluate the psychometric properties of the ICD-body image concerns questionnaire (BICQ), find a cut-off indicating BICs and determine the prevalence of BICs. Construct validity was determined using the Kaiser-Meyer-Olkin test, Scree-plot and explorative factor analysis. Internal consistency was examined via Cronbach's alpha. Correlations to other validated questionnaires, a weighted and simple scale and a cut-off indicating BICs was evaluated. Results In total, 331 patients completed the 39-item ICD-BICQ together with: Type D Scale (DS14), Generalized Anxiety Disorder scale (GAD-7), Patient Health Questionnaire (PHQ-9), and Florida Patient Acceptance Survey. Five patients were excluded due to reoperations, leaving 326 patients in the analyses. Results revealed a one-factor structure with 32 items and Cronbach's alpha at .948. A cut-off at 36 points displayed the 20% patients with the highest score of BICs. The prevalence was 29.8% in women and 18.4% in men. Conclusion The psychometric evaluation of the 32-item ICD-BICQ showed acceptable construct validity and internal reliability. We recommend a cut-off score at 36 points to identify patients at risk of having BICs. The prevalence of BICs indicated that both men and women are at risk of having BICs. The ICD-BICQ can be used in clinical practice to help healthcare professionals to identify patients at risk of BICs and as to evaluate BICs when implementing new operation techniques.

ACS Style

Vivi Skibdal Frydensberg; Jens Brock Johansen; Sören Möller; Anna Strömberg; Susanne S. Pedersen. Psychometric evaluation of the implantable cardioverter defibrillator body image concerns questionnaire (ICD‐BICQ). Journal of Cardiovascular Electrophysiology 2021, 32, 2295 -2311.

AMA Style

Vivi Skibdal Frydensberg, Jens Brock Johansen, Sören Möller, Anna Strömberg, Susanne S. Pedersen. Psychometric evaluation of the implantable cardioverter defibrillator body image concerns questionnaire (ICD‐BICQ). Journal of Cardiovascular Electrophysiology. 2021; 32 (8):2295-2311.

Chicago/Turabian Style

Vivi Skibdal Frydensberg; Jens Brock Johansen; Sören Möller; Anna Strömberg; Susanne S. Pedersen. 2021. "Psychometric evaluation of the implantable cardioverter defibrillator body image concerns questionnaire (ICD‐BICQ)." Journal of Cardiovascular Electrophysiology 32, no. 8: 2295-2311.

Journal article
Published: 26 May 2021 in Cancers
Reads 0
Downloads 0

Quality of life data from randomized trials are lacking in older patients with metastatic colorectal cancer (mCRC). In the randomized NORDIC9-study, reduced-dose S1+oxaliplatin (SOx) showed superior efficacy compared to full-dose S1 monotherapy. We hypothesized that treatment with SOx does not result in inferior quality of life. Patients with mCRC aged ≥70 years and that were not a candidate for standard combination chemotherapy were included and randomly assigned to receive either S1 or SOx. The EORTC QLQ-C30 questionnaire was completed at baseline, after 9, and 18 weeks. The primary endpoint was global Quality of Life (QoL) at 9 weeks. For statistical analysis, a non-inferiority design was chosen applying linear mixed effects models for repeated measurements. The results were interpreted according to statistical significance and anchor-based, clinically relevant between-group minimally important differences (MID). A total of 160 patients aged (median (Interquartile range (IQR))) 78 years (76–81) were included. The QLQ-C30 questionnaire was completed by 150, 100, and 60 patients at baseline, at 9, and 18 weeks, respectively. The difference at 9 weeks in global QoL was 6.85 (95%CI—1.94; 15.65) and 7.37 (0.70; 14.05) in the physical functioning domain in favor of SOx exceeding the threshold for MID. At 18 weeks, the between-group MID in physical functioning was preserved. Dose-reduced combination chemotherapy may be recommended in vulnerable older patients with mCRC, rather than full-dose monotherapy.

ACS Style

Gabor Liposits; Henrik Eshøj; Sören Möller; Stine Winther; Halla Skuladottir; Jesper Ryg; Eva Hofsli; Carl-Henrik Shah; Laurids Poulsen; Åke Berglund; Camilla Qvortrup; Pia Österlund; Bengt Glimelius; Halfdan Sorbye; Per Pfeiffer. Quality of Life in Vulnerable Older Patients with Metastatic Colorectal Cancer Receiving Palliative Chemotherapy—The Randomized NORDIC9-Study. Cancers 2021, 13, 2604 .

AMA Style

Gabor Liposits, Henrik Eshøj, Sören Möller, Stine Winther, Halla Skuladottir, Jesper Ryg, Eva Hofsli, Carl-Henrik Shah, Laurids Poulsen, Åke Berglund, Camilla Qvortrup, Pia Österlund, Bengt Glimelius, Halfdan Sorbye, Per Pfeiffer. Quality of Life in Vulnerable Older Patients with Metastatic Colorectal Cancer Receiving Palliative Chemotherapy—The Randomized NORDIC9-Study. Cancers. 2021; 13 (11):2604.

Chicago/Turabian Style

Gabor Liposits; Henrik Eshøj; Sören Möller; Stine Winther; Halla Skuladottir; Jesper Ryg; Eva Hofsli; Carl-Henrik Shah; Laurids Poulsen; Åke Berglund; Camilla Qvortrup; Pia Österlund; Bengt Glimelius; Halfdan Sorbye; Per Pfeiffer. 2021. "Quality of Life in Vulnerable Older Patients with Metastatic Colorectal Cancer Receiving Palliative Chemotherapy—The Randomized NORDIC9-Study." Cancers 13, no. 11: 2604.

Original article
Published: 25 May 2021 in International Journal of Audiology
Reads 0
Downloads 0

Primarily to understand whether clinically relevant factors affect the International Outcome Inventory (IOI-HA) scores and to examine if IOI-HA scores improve when renewing the hearing aids (HA) for experienced users. Secondly, to estimate the overall HA effectiveness using the IOI-HA. A prospective observational study. In total, 1961 patients with hearing loss were included. All patients underwent a hearing examination, were fitted with HAs, and answered the IOI-HA. Factor analysis of IOI-HA separated the items into a Factor 1 (use of HA, perceived benefits, satisfaction, and quality of life) and Factor 2 (residual activity limitation, residual participation restriction and impact on others) score. Degree of hearing loss, word recognition score, motivation, HA usage time, tinnitus, asymmetry, and sex were significantly associated with total IOI-HA, Factor 1, or Factor 2 scores. The seven IOI-HA items increased on average by 0.4 (p < 0.001) when renewing HAs. The total median IOI-HA score at follow-up was 29 (7) for experienced (n = 460) and first-time users (n = 1189), respectively. Degree of hearing loss, word recognition score, motivation, tinnitus, asymmetry, and sex may be used to identify patients who require special attention to become successful HA users.

ACS Style

S. S. Houmøller; A. Wolff; S. Möller; V. K. Narne; S. K. Narayanan; C. Godballe; D. D. Hougaard; G. Loquet; M. Gaihede; D. Hammershøi; J. H. Schmidt. Prediction of successful hearing aid treatment in first-time and experienced hearing aid users: Using the International Outcome Inventory for Hearing Aids. International Journal of Audiology 2021, 1 -11.

AMA Style

S. S. Houmøller, A. Wolff, S. Möller, V. K. Narne, S. K. Narayanan, C. Godballe, D. D. Hougaard, G. Loquet, M. Gaihede, D. Hammershøi, J. H. Schmidt. Prediction of successful hearing aid treatment in first-time and experienced hearing aid users: Using the International Outcome Inventory for Hearing Aids. International Journal of Audiology. 2021; ():1-11.

Chicago/Turabian Style

S. S. Houmøller; A. Wolff; S. Möller; V. K. Narne; S. K. Narayanan; C. Godballe; D. D. Hougaard; G. Loquet; M. Gaihede; D. Hammershøi; J. H. Schmidt. 2021. "Prediction of successful hearing aid treatment in first-time and experienced hearing aid users: Using the International Outcome Inventory for Hearing Aids." International Journal of Audiology , no. : 1-11.

Journal article
Published: 21 May 2021 in International Journal of Environmental Research and Public Health
Reads 0
Downloads 0

Relative risk (RR) is a preferred measure for investigating associations in clinical and epidemiological studies with dichotomous outcomes. However, if the outcome of interest is rare, it frequently occurs that no events are observed in one of the comparison groups. In this case, many of the standard methods used to obtain confidence intervals (CIs) for the RRs are not feasible, even in studies with strong statistical evidence of an association. Different strategies for solving this challenge have been suggested in the literature. This paper, which uses both mathematical arguments and statistical simulations, aims to present, compare, and discuss the different statistical approaches to obtain CIs for RRs in the case of no events in one of the comparison groups. Moreover, we compare these frequentist methods with Bayesian approaches to determine credibility intervals (CrIs) for the RRs. Our results indicate that most of the suggested approaches can be used to obtain CIs (or CrIs) for RRs in the case of no events, although one-sided intervals obtained by methods based on deliberate, probabilistic considerations should be preferred over ad hoc methods. In addition, we demonstrate that Bayesian approaches can be used to obtain CrIs in these situations. Thus, it is possible to obtain statistical inference for the RR, even in studies with no events in one of the comparison groups, and CIs for the RRs should always be provided. However, it is important to note that the obtained intervals are sensitive to the method chosen in the case of small sample sizes.

ACS Style

Sören Möller; Linda Ahrenfeldt. Estimating Relative Risk When Observing Zero Events—Frequentist Inference and Bayesian Credibility Intervals. International Journal of Environmental Research and Public Health 2021, 18, 5527 .

AMA Style

Sören Möller, Linda Ahrenfeldt. Estimating Relative Risk When Observing Zero Events—Frequentist Inference and Bayesian Credibility Intervals. International Journal of Environmental Research and Public Health. 2021; 18 (11):5527.

Chicago/Turabian Style

Sören Möller; Linda Ahrenfeldt. 2021. "Estimating Relative Risk When Observing Zero Events—Frequentist Inference and Bayesian Credibility Intervals." International Journal of Environmental Research and Public Health 18, no. 11: 5527.

Commentary
Published: 14 May 2021 in BJOG: An International Journal of Obstetrics & Gynaecology
Reads 0
Downloads 0

Further debate about the effect of incisional negative pressure wound therapy (iNPWT) versus standard wound dressing on surgical‐site infection (SSI) in obese women after caesarean section (CS) has resurfaced. This is because of a study published in JAMA1 that was stopped early on the grounds of “futility”. This was counterintuitive to us having published a systematic review,2 a randomised controlled trial (RCT)3 and a health economic evaluation on the same subject,4 the latter two of which were published in BJOG.

ACS Style

Nana Hyldig; Jan Stener Joergensen; Ronald F. Lamont; Sören Möller; Christina Anne Vinter. Prophylactic negative pressure wound therapy in obese women undergoing caesarean section: a commentary on new evidence that fuels the debate. BJOG: An International Journal of Obstetrics & Gynaecology 2021, 1 .

AMA Style

Nana Hyldig, Jan Stener Joergensen, Ronald F. Lamont, Sören Möller, Christina Anne Vinter. Prophylactic negative pressure wound therapy in obese women undergoing caesarean section: a commentary on new evidence that fuels the debate. BJOG: An International Journal of Obstetrics & Gynaecology. 2021; ():1.

Chicago/Turabian Style

Nana Hyldig; Jan Stener Joergensen; Ronald F. Lamont; Sören Möller; Christina Anne Vinter. 2021. "Prophylactic negative pressure wound therapy in obese women undergoing caesarean section: a commentary on new evidence that fuels the debate." BJOG: An International Journal of Obstetrics & Gynaecology , no. : 1.

Journal article
Published: 10 May 2021 in International Journal of Environmental Research and Public Health
Reads 0
Downloads 0

It is well recognized that socioeconomic status (SES) is an important determinant of health, but many studies fail to address the possibility of reverse causation. We aim to investigate the reciprocal relationship between trajectories of SES and health, and how these associations differ by sex. We performed a longitudinal study including 29,824 men and 37,263 women aged 50+ participating in at least two consecutive waves of the Survey of Health, Ageing and Retirement in Europe (SHARE). Using structural equation modeling, we found that baseline household income and wealth led to improvements in cognitive function, grip strength, quality of life and depressive symptoms, and a better initial health led to higher income and wealth for both sexes. However, the results indicated that the relative effect of cognitive function and grip strength on SES trajectories was overall greater than the corresponding effect of SES on health changes, particularly regarding income among women, but for quality of life and depressive symptoms, the reverse was indicated, though most pronounced for the associations with wealth. The reciprocal associations between SES and physical function were stronger for men than for women, whereas most associations with cognitive function and mental health were similar between sexes. This study demonstrates that both social causation and health selection contribute to social inequalities in health, but the influence of each direction and the importance of sex differences may vary according to the health outcomes investigated.

ACS Style

Linda Ahrenfeldt; Sören Möller. The Reciprocal Relationship between Socioeconomic Status and Health and the Influence of Sex: A European SHARE-Analysis Based on Structural Equation Modeling. International Journal of Environmental Research and Public Health 2021, 18, 5045 .

AMA Style

Linda Ahrenfeldt, Sören Möller. The Reciprocal Relationship between Socioeconomic Status and Health and the Influence of Sex: A European SHARE-Analysis Based on Structural Equation Modeling. International Journal of Environmental Research and Public Health. 2021; 18 (9):5045.

Chicago/Turabian Style

Linda Ahrenfeldt; Sören Möller. 2021. "The Reciprocal Relationship between Socioeconomic Status and Health and the Influence of Sex: A European SHARE-Analysis Based on Structural Equation Modeling." International Journal of Environmental Research and Public Health 18, no. 9: 5045.

Journal article
Published: 03 May 2021 in Stem Cell Research & Therapy
Reads 0
Downloads 0

Background Transplantation of human bone marrow stromal cells (hBMSCs) is a promising therapy for bone regeneration due to their ability to differentiate into bone forming osteoblastic cells. However, transplanted hBMSCs exhibit variable capacity for bone formation resulting in inconsistent clinical outcome. The aim of the study was to identify a set of donor- and cell-related characteristics that detect hBMSCs with optimal osteoblastic differentiation capacity. Methods We collected hBMSCs from 58 patients undergoing surgery for bone fracture. Clinical profile of the donors and in vitro characteristics of cultured hBMSCs were included in uni- and multivariable analysis to determine their predictive value for osteoblastic versus adipocytic differentiation capacity assessed by quantification of mineralized matrix and mature adipocyte formation, respectively. Results We identified a signature that explained > 50% of variation in osteoblastic differentiation outcome which included the following positive predictors: donor sex (male), absence of osteoporosis diagnosis, intake of vitamin D supplements, higher fraction of CD146+, and alkaline phosphate (ALP+) cells. With the exception of vitamin D and ALP+ cells, these variables were also negative predictors of adipocytic differentiation. Conclusions Using a combination of clinical and cellular criteria, it is possible to predict differentiation outcome of hBMSCs. This signature may be helpful in selecting donor cells in clinical trials of bone regeneration.

ACS Style

Justyna Magdalena Kowal; Sören Möller; Dalia Ali; Florence Figeac; Torben Barington; Hagen Schmal; Moustapha Kassem. Identification of a clinical signature predictive of differentiation fate of human bone marrow stromal cells. Stem Cell Research & Therapy 2021, 12, 1 -15.

AMA Style

Justyna Magdalena Kowal, Sören Möller, Dalia Ali, Florence Figeac, Torben Barington, Hagen Schmal, Moustapha Kassem. Identification of a clinical signature predictive of differentiation fate of human bone marrow stromal cells. Stem Cell Research & Therapy. 2021; 12 (1):1-15.

Chicago/Turabian Style

Justyna Magdalena Kowal; Sören Möller; Dalia Ali; Florence Figeac; Torben Barington; Hagen Schmal; Moustapha Kassem. 2021. "Identification of a clinical signature predictive of differentiation fate of human bone marrow stromal cells." Stem Cell Research & Therapy 12, no. 1: 1-15.

Original investigation
Published: 03 May 2021 in JAMA Network Open
Reads 0
Downloads 0

Anticoagulant and antiplatelet drugs offer clear clinical benefits in the treatment and prevention of thrombosis, but their use is also associated with an increased risk of intracerebral hemorrhage (ICH).1-3 Although less common than gastrointestinal hemorrhage, ICH is a severe complication with high case fatality in the setting of antithrombotic therapy.3,4 Therefore, the advent of direct oral anticoagulants (DOACs) that were reported to be associated with reduced risk of ICH compared with warfarin in clinical trials in patients with atrial fibrillation3 represented a major advance in oral anticoagulant (OAC) therapy. However, although intracranial hemorrhages (encompassing intracerebral, subdural, and subarachnoid hemorrhages) have been extensively studied as untoward effects of DOACs in observational studies,2,5-28 this is less the case for ICH. Observational studies that specifically present data on the risk of ICH associated with OAC use mostly predate the introduction1,29,30 and more widespread use of DOACs2 or report data only on patients with atrial fibrillation.31 Currently, preadmission use of OACs—alone or combined with antiplatelets—is relatively frequent among patients admitted for ICH.32 Antithrombotic drugs are frequently used by older people, the demographic segment with the largest projected increase worldwide in years to come.33 Observational studies can provide insights regarding the association of ICH with antithrombotic drug use in the wider population, including vulnerable populations, such as older people and patients with coexisting conditions, who are often less well represented in clinical trials.

ACS Style

Stine Munk Hald; Sören Möller; Luis Alberto García Rodríguez; Rustam Al-Shahi Salman; Mike Sharma; Hanne Christensen; Maja Hellfritzsch; Anton Pottegård; Jesper Hallas; David Gaist. Trends in Incidence of Intracerebral Hemorrhage and Association With Antithrombotic Drug Use in Denmark, 2005-2018. JAMA Network Open 2021, 4, e218380 -e218380.

AMA Style

Stine Munk Hald, Sören Möller, Luis Alberto García Rodríguez, Rustam Al-Shahi Salman, Mike Sharma, Hanne Christensen, Maja Hellfritzsch, Anton Pottegård, Jesper Hallas, David Gaist. Trends in Incidence of Intracerebral Hemorrhage and Association With Antithrombotic Drug Use in Denmark, 2005-2018. JAMA Network Open. 2021; 4 (5):e218380-e218380.

Chicago/Turabian Style

Stine Munk Hald; Sören Möller; Luis Alberto García Rodríguez; Rustam Al-Shahi Salman; Mike Sharma; Hanne Christensen; Maja Hellfritzsch; Anton Pottegård; Jesper Hallas; David Gaist. 2021. "Trends in Incidence of Intracerebral Hemorrhage and Association With Antithrombotic Drug Use in Denmark, 2005-2018." JAMA Network Open 4, no. 5: e218380-e218380.

Journal article
Published: 01 May 2021 in Journal of Geriatric Oncology
Reads 0
Downloads 0

A growing number of older patients with cancer require well-founded clinical decision-making. Frailty screening is suggested as a service to improve outcomes in vulnerable older patients with cancer. This prospective study examined the value of frailty screening to predict rapid functional decline, rapid progressive disease (PD) and shorter overall survival (OS) in older patients with gastrointestinal cancer receiving palliative chemotherapy. Patients aged ≥70 years were screened for frailty in an oncologic department after clinical decision but before starting palliative chemotherapy. Screening was repeated at first response evaluation after approximately two months of chemotherapy. Frailty screening tools included performance status (PS), Charlson Comorbidity Index, G-8 using two different cut-offs (G814,G811), VES-13, Timed-Up-and-Go, Handgrip strength and falls. A total of 170 patients were included, median age was 75.5 (70-88) years and 65.9% were male. The frequency of frailty varied from 14% to 74% according to the chosen frailty tool. In multivariate analysis G814 predicted OS (HR 1.5; 95%CI 1.0-2.4), whereas G811 predicted PD (OR 2.4; 1.1-5.6) and OS (HR 2.1; 1.4-2.9). VES-13 predicted functional decline (OR 3.5; 1.0-11.6), PD (OR 3.5; 1.5-8.4) and OS (HR 1.7; 1.2-2.4). Timed-Up-and-Go predicted OS (HR 1.8; 1.1-2.7). Handgrip strength and falls predicted functional decline (OR 4.5; 1.1-19 and OR 6.1; 1.4-25.8, respectively). PS predicted PD (OR 6.2; 2.6-14.7) and OS (HR 2.2; 1.5-3.2). VES-13 was useful for predicting all three endpoints of interest. Frailty tools covering domains of functioning and nutrition are suggested for older patients with advanced gastrointestinal cancer.

ACS Style

Eva Jespersen; Stine Braendegaard Winther; Lisbeth Rosenbek Minet; Sören Möller; Per Pfeiffer. Frailty screening for predicting rapid functional decline, rapid progressive disease, and shorter overall survival in older patients with gastrointestinal cancer receiving palliative chemotherapy - a prospective, clinical study. Journal of Geriatric Oncology 2021, 12, 578 -584.

AMA Style

Eva Jespersen, Stine Braendegaard Winther, Lisbeth Rosenbek Minet, Sören Möller, Per Pfeiffer. Frailty screening for predicting rapid functional decline, rapid progressive disease, and shorter overall survival in older patients with gastrointestinal cancer receiving palliative chemotherapy - a prospective, clinical study. Journal of Geriatric Oncology. 2021; 12 (4):578-584.

Chicago/Turabian Style

Eva Jespersen; Stine Braendegaard Winther; Lisbeth Rosenbek Minet; Sören Möller; Per Pfeiffer. 2021. "Frailty screening for predicting rapid functional decline, rapid progressive disease, and shorter overall survival in older patients with gastrointestinal cancer receiving palliative chemotherapy - a prospective, clinical study." Journal of Geriatric Oncology 12, no. 4: 578-584.

Psoriatic arthritis
Published: 29 April 2021 in Annals of the Rheumatic Diseases
Reads 0
Downloads 0

Objectives Although causality remains to be established, targeting dysbiosis of the intestinal microbiota by faecal microbiota transplantation (FMT) has been proposed as a novel treatment for inflammatory diseases. In this exploratory, proof-of-concept study, we evaluated the safety and efficacy of FMT in psoriatic arthritis (PsA). Methods In this double-blind, parallel-group, placebo-controlled, superiority trial, we randomly allocated (1:1) adults with active peripheral PsA (≥3 swollen joints) despite ongoing treatment with methotrexate to one gastroscopic-guided FMT or sham transplantation into the duodenum. Safety was monitored throughout the trial. The primary efficacy endpoint was the proportion of participants experiencing treatment failure (ie, needing treatment intensification) through 26 weeks. Key secondary endpoints were change in Health Assessment Questionnaire Disability Index (HAQ-DI) and American College of Rheumatology (ACR20) response at week 26. Results Of 97 screened, 31 (32%) underwent randomisation (15 allocated to FMT) and 30 (97%) completed the 26-week clinical evaluation. No serious adverse events were observed. Treatment failure occurred more frequently in the FMT group than in the sham group (9 (60%) vs 3 (19%); risk ratio, 3.20; 95% CI 1.06 to 9.62; p=0.018). Improvement in HAQ-DI differed between groups (0.07 vs 0.30) by 0.23 points (95% CI 0.02 to 0.44; p=0.031) in favour of sham. There was no difference in the proportion of ACR20 responders between groups (7 of 15 (47%) vs 8 of 16 (50%)). Conclusions In this first preliminary, interventional randomised controlled trial of FMT in immune-mediated arthritis, we did not observe any serious adverse events. Overall, FMT appeared to be inferior to sham in treating active peripheral PsA. Trial registration number NCT03058900.

ACS Style

Maja Skov Kragsnaes; Jens Kjeldsen; Hans Christian Horn; Heidi Lausten Munk; Jens Kristian Pedersen; Søren Andreas Just; Palle Ahlquist; Finn Moeller Pedersen; Maarten de Wit; Sören Möller; Vibeke Andersen; Karsten Kristiansen; Dorte Kinggaard Holm; Hanne Marie Holt; Robin Christensen; Torkell Ellingsen. Safety and efficacy of faecal microbiota transplantation for active peripheral psoriatic arthritis: an exploratory randomised placebo-controlled trial. Annals of the Rheumatic Diseases 2021, 80, 1158 -1167.

AMA Style

Maja Skov Kragsnaes, Jens Kjeldsen, Hans Christian Horn, Heidi Lausten Munk, Jens Kristian Pedersen, Søren Andreas Just, Palle Ahlquist, Finn Moeller Pedersen, Maarten de Wit, Sören Möller, Vibeke Andersen, Karsten Kristiansen, Dorte Kinggaard Holm, Hanne Marie Holt, Robin Christensen, Torkell Ellingsen. Safety and efficacy of faecal microbiota transplantation for active peripheral psoriatic arthritis: an exploratory randomised placebo-controlled trial. Annals of the Rheumatic Diseases. 2021; 80 (9):1158-1167.

Chicago/Turabian Style

Maja Skov Kragsnaes; Jens Kjeldsen; Hans Christian Horn; Heidi Lausten Munk; Jens Kristian Pedersen; Søren Andreas Just; Palle Ahlquist; Finn Moeller Pedersen; Maarten de Wit; Sören Möller; Vibeke Andersen; Karsten Kristiansen; Dorte Kinggaard Holm; Hanne Marie Holt; Robin Christensen; Torkell Ellingsen. 2021. "Safety and efficacy of faecal microbiota transplantation for active peripheral psoriatic arthritis: an exploratory randomised placebo-controlled trial." Annals of the Rheumatic Diseases 80, no. 9: 1158-1167.

Original research
Published: 22 April 2021 in BMJ Quality & Safety
Reads 0
Downloads 0

Background Patient-centredness is an essential quality parameter of modern healthcare. Accordingly, involving patients in decisions about care is required by international laws and an increasing number of medical codes and standards. These directives are based on ethical principles of autonomy. Still, there is limited empirical knowledge about the influence of patient involvement on satisfaction with care. Objective In a large national vignette survey, we aimed to empirically test healthcare users’ satisfaction with healthcare given different degrees of patient involvement, choices made and outcomes. Methods A web-based cross-sectional survey distributed to a randomised sample of men in Denmark aged 45–70 years. Case vignettes used prostate-specific antigen (PSA) screening for early detection of prostate cancer as a clinical model. Using a 5-point Likert scale, we measured respondents’ satisfaction with care in scenarios which differed in the amount of patient involvement (ranging from no involvement, through involvement with neutral or nudged information, to shared decision-making), the decision made (PSA test or no PSA test) and clinical outcomes (no cancer detected, detection of treatable cancer and detection of non-treatable cancer). Results Participating healthcare users tended to be more satisfied with healthcare in scenarios illustrating greater levels of patient involvement. Participants were positive towards nudging in favour of the intervention but patient involvement through shared decision-making obtained the highest satisfaction ratings (Likert rating 3.81 without any involvement vs 4.07 for shared decision-making, p<0.001). Greater involvement also had an ameliorating effect on satisfaction if a non-treatable cancer was later diagnosed. Conclusion Our study provides empirical support for the hypothesis that greater patient involvement in healthcare decision-making improves satisfaction with care irrespective of decisions made and clinical outcomes. Overall satisfaction with the care illustrated was highest when decisions were reached through shared decision-making.

ACS Style

Søren Birkeland; Marie Bismark; Michael John Barry; Sören Möller. Is greater patient involvement associated with higher satisfaction? Experimental evidence from a vignette survey. BMJ Quality & Safety 2021, 1 .

AMA Style

Søren Birkeland, Marie Bismark, Michael John Barry, Sören Möller. Is greater patient involvement associated with higher satisfaction? Experimental evidence from a vignette survey. BMJ Quality & Safety. 2021; ():1.

Chicago/Turabian Style

Søren Birkeland; Marie Bismark; Michael John Barry; Sören Möller. 2021. "Is greater patient involvement associated with higher satisfaction? Experimental evidence from a vignette survey." BMJ Quality & Safety , no. : 1.

Original article
Published: 16 April 2021 in Alcoholism: Clinical and Experimental Research
Reads 0
Downloads 0

Background Only a minority of individuals with problematic alcohol use ever seek alcohol treatment. Knowledge of general help‐seeking behavior in the healthcare system can identify possibilities for prevention and intervention. Method The current study describes healthcare use, burden of disease, and prior morbidities over a 15‐year period by current alcohol use behavior among Danish adults aged 60–70. The Danish National Health Survey 2013 and the baseline assessment of the Elderly Study (2014–2016) were linked to Danish national registers to collect annual information on healthcare use and morbidity for the 15 years prior to inclusion. Participants from the 3 largest Danish municipalities were divided into 4 groups with varying drinking patterns and no recent treatment [12‐month abstinent (n = 691), low‐risk drinkers (n = 1978), moderate‐risk drinkers (n = 602), and high‐risk drinkers (n = 467)], and a group of treatment‐seeking individuals with a 12‐month DSM‐5 alcohol use disorder (AUD; n=262). Negative binomial regression models were utilized to compare rates of healthcare use and logistic regressions were used to compare odds of diagnoses. Results Low‐, moderate‐, and high‐risk drinkers had similar rates of past healthcare utilization (low‐risk mean yearly number of contacts for primary care 7.50 (yearly range 6.25–8.45), outpatient care 0.80 (0.41–1.32) and inpatient care 0.13 (0.10–0.21)). Higher rates were observed for both the 12‐month abstinent group (adjusted RR = 1.16–1.26) and the group with AUD (ARR = 1.40–1.60) compared to the group with low‐risk alcohol consumption. Individuals with AUD had higher odds of previous liver disease (adjusted OR = 6.30), ulcer disease (AOR = 2.83), and peripheral vascular disease (AOR 2.71). Twelve‐month abstinence was associated with higher odds of diabetes (AOR = 1.97) and ulcer disease (AOR = 2.10). Conclusions Looking back in time, we found that older adults had regular healthcare contacts, with those who received treatment for AUD having had the highest contact frequency and prevalence of alcohol‐related diseases. Thus, healthcare settings are suitable locations for efforts at AUD prevention and intervention.

ACS Style

Anna Mejldal; Kjeld Andersen; Silke Behrendt; Randi Bilberg; Anne Illemann Christensen; Cathrine Juel Lau; Sören Möller; Anette Søgaard Nielsen. History of healthcare use and disease burden in older adults with different levels of alcohol use. A register‐based cohort study. Alcoholism: Clinical and Experimental Research 2021, 45, 1237 -1248.

AMA Style

Anna Mejldal, Kjeld Andersen, Silke Behrendt, Randi Bilberg, Anne Illemann Christensen, Cathrine Juel Lau, Sören Möller, Anette Søgaard Nielsen. History of healthcare use and disease burden in older adults with different levels of alcohol use. A register‐based cohort study. Alcoholism: Clinical and Experimental Research. 2021; 45 (6):1237-1248.

Chicago/Turabian Style

Anna Mejldal; Kjeld Andersen; Silke Behrendt; Randi Bilberg; Anne Illemann Christensen; Cathrine Juel Lau; Sören Möller; Anette Søgaard Nielsen. 2021. "History of healthcare use and disease burden in older adults with different levels of alcohol use. A register‐based cohort study." Alcoholism: Clinical and Experimental Research 45, no. 6: 1237-1248.

Original article
Published: 11 April 2021 in Journal of Public Health
Reads 0
Downloads 0

International health authorities suggest that individuals aged 65 years and above and people with underlying comorbidities such as hypertension, chronic lung disease, cardiovascular disease, cancer, diabetes, and obesity are at increased risk of severe Coronavirus Disease 2019 (COVID-19); however, the prevalence of risk factors is unknown in many countries. Therefore, we aimed to describe the distribution of these risk factors across Europe. Prevalence of risk factors for severe COVID-19 was identified based on interviews from 73,274 Europeans aged 50+ participating in the Survey of Health, Ageing and Retirement in Europe (SHARE) in 2017. Burden of disease was estimated using population data from Eurostat. A total of 75.3% of the study population (corresponding to approx. 60 million European men and 71 million women) had at least one risk factor for severe COVID-19, 45.9% (approx. 36 million men and 43 million women) had at least two factors, and 21.2% (approx. 17 million men and 20 million women) had at least three risk factors. The prevalence of underlying medical conditions ranged from 4.5% for cancer to 41.4% for hypertension, and the region-specific prevalence of having at least three risk factors ranged from 18.9% in Northern Europe to 24.6% in Eastern Europe. Information about the prevalence of risk factors might help authorities to identify the most vulnerable subpopulations with multiple risk factors of severe COVID-19 and thus to decide appropriate strategies to mitigate the pandemic.

ACS Style

Linda Juel Ahrenfeldt; Camilla Riis Nielsen; Sören Möller; Kaare Christensen; Rune Lindahl-Jacobsen. Burden and prevalence of risk factors for severe COVID-19 in the ageing European population – a SHARE-based analysis. Journal of Public Health 2021, 1 -10.

AMA Style

Linda Juel Ahrenfeldt, Camilla Riis Nielsen, Sören Möller, Kaare Christensen, Rune Lindahl-Jacobsen. Burden and prevalence of risk factors for severe COVID-19 in the ageing European population – a SHARE-based analysis. Journal of Public Health. 2021; ():1-10.

Chicago/Turabian Style

Linda Juel Ahrenfeldt; Camilla Riis Nielsen; Sören Möller; Kaare Christensen; Rune Lindahl-Jacobsen. 2021. "Burden and prevalence of risk factors for severe COVID-19 in the ageing European population – a SHARE-based analysis." Journal of Public Health , no. : 1-10.