Based on a full factorial experimental design, the effects of the feed ratio, atomizer speed, and inlet air temperature on properties of spray-dried orange juice powders were investigated. The results indicate that increasing inlet air temperature increases the particle size, average time of wettablity, and insoluble solids and decreases the bulk density and moisture content of the powder. Increasing atomizer speed results in increasing the bulk density and average time of wettablity of powder and decreases the particle size, moisture content, and insoluble solids of powder. Increase in feed flow rate increases the bulk density, particle size, and moisture content of the powder and decreases the average time of wettablity and insoluble solids of powder. With multivariable regression analysis the relationships between physical properties of orange juice powder and operating parameters with high coefficient were obtained.