Accurate detection and classification of lung malignancies are crucial for early diagnosis, treatment planning, and patient prognosis. Conventional histopathological analysis is time-consuming, limiting its clinical applicability. To address this, we present a dataset of 691 high-resolution (1200 × 1600 pixels) histopathological lung images, covering adenocarcinomas, squamous cell carcinomas, and normal tissues from 45 patients. These images are subdivided into three differentiation levels for both pathological types: well, moderately, and poorly differentiated, resulting in seven classes for classification. The dataset includes images at 20x and 40x magnification, reflecting real clinical diversity. We evaluated image classification using deep neural network and multiple instance learning approaches. Each method was used to classify images at 20x and 40x magnification into three superclasses. We achieved accuracies between 81% and 92%, depending on the method and resolution, demonstrating the dataset’s utility.

Colon Capsule Endoscopy (CCE) is a minimally invasive procedure which is increasingly being used as an alternative to conventional colonoscopy. Videos recorded by the capsule cameras are long and require one or more experts' time to review and identify polyps or other potential intestinal problems that can lead to major health issues. We developed and tested a multi-platform web application, AI-Tool, which embeds a Convolution Neural Network (CNN) to help CCE reviewers. With the help of artificial intelligence, AI-Tool is able to detect images with high probability of containing a polyp and prioritize them during the reviewing process. With the collaboration of 3 experts that reviewed 18 videos, we compared the classical linear review method using RAPID Reader Software v9.0 and the new software we present. Applying the new strategy, reviewing time was reduced by a factor of 6 and polyp detection sensitivity was increased from 81.08 to 87.80%.

In today’s digital landscape, recommender systems have gained ubiquity as a means of directing users toward personalized products, services, and content. However, despite their widespread adoption and a long track of research, these systems are not immune to shortcomings. A significant challenge faced by recommender systems is the presence of biases, which produces various undesirable effects, prominently the popularity bias. This bias hampers the diversity of recommended items, thus restricting users’ exposure to less popular or niche content. Furthermore, this issue is compounded when multiple stakeholders are considered, requiring the balance of multiple, potentially conflicting objectives. In this article, we present a new approach to address a wide range of undesired consequences in recommender systems that involve various stakeholders. Instead of adopting a consequentialist perspective that aims to mitigate the repercussions of a recommendation policy, we propose a deontological approach centered around a minimal set of ethical principles. More precisely, we introduce two distinct principles aimed at avoiding overconfidence in predictions and accurately modeling the genuine interests of users. The proposed approach circumvents the need for defining a multi-objective system, which has been identified as one of the main limitations when developing complex recommenders. Through extensive experimentation, we show the efficacy of our approach in mitigating the adverse impact of the recommender from both user and item perspectives, ultimately enhancing various beyond accuracy metrics. This study underscores the significance of responsible and equitable recommendations and proposes a strategy that can be easily deployed in real-world scenarios.

Background: Colon capsule endoscopy (CCE) has seen increased adoption since the COVID-19 pandemic, offering a non-invasive alternative for lower gastrointestinal investigations. However, inadequate bowel preparation remains a key limitation, often leading to higher conversion rates to colonoscopy. Manual assessment of bowel cleanliness is inherently subjective and marked by high interobserver variability. Recent advances in artificial intelligence (AI) have enabled automated cleansing scores that not only standardise assessment and reduce variability but also align with the emerging semi-automated AI reading workflow, which highlights only clinically significant frames. As full video review becomes less routine, reliable, and consistent, cleansing evaluation is essential, positioning bowel preparation AI as a critical enabler of diagnostic accuracy and scalable CCE deployment. Objective: This CESCAIL sub-study aimed to (1) evaluate interobserver agreement in CCE bowel cleansing assessment using two established scoring systems, and (2) determine the impact of AI-assisted scoring, specifically a TransUNet-based segmentation model with a custom Patch Loss function, on both interobserver and intraobserver agreement compared to manual assessment. Methods: As part of the CESCAIL study, twenty-five CCE videos were randomly selected from 673 participants. Nine readers with varying CCE experience scored bowel cleanliness using the Leighton–Rex and CC-CLEAR scales. After a minimum 8-week washout, the same readers reassessed the videos using AI-assisted CC-CLEAR scores. Interobserver variability was evaluated using bootstrapped intraclass correlation coefficients (ICC) and Fleiss’ Kappa; intraobserver variability was assessed with weighted Cohen’s Kappa, paired t-tests, and Two One-Sided Tests (TOSTs). Results: Leighton–Rex showed poor to fair agreement (Fleiss = 0.14; ICC = 0.55), while CC-CLEAR demonstrated fair to excellent agreement (Fleiss = 0.27; ICC = 0.90). AI-assisted CC-CLEAR achieved only moderate agreement overall (Fleiss = 0.27; ICC = 0.69), with weaker performance among less experienced readers (Fleiss = 0.15; ICC = 0.56). Intraobserver agreement was excellent (ICC > 0.75) for experienced readers but variable in others (ICC 0.03–0.80). AI-assisted scores were significantly lower than manual reads by 1.46 points (p < 0.001), potentially increasing conversion to colonoscopy. Conclusions: AI-assisted scoring did not improve interobserver agreement and may even reduce consistency amongst less experienced readers. The maintained agreement observed in experienced readers highlights its current value in experienced hands only. Further refinement, including spatial analysis integration, is needed for robust overall AI implementation in CCE.

(1) Background: Accurate evaluation of colon capsule endoscopy videos plays a pivotal role in diagnosing gastrointestinal disorders. A primary step in this process is assessing the cleanliness of the area of interest to determine its admissibility. This study introduces a system designed to assist physicians in evaluating the colon cleanliness score of capsule endoscopy videos. (2) Methods: The system uses a TransUNet architecture, a customized loss function, and a low-effort labeling method to propose cleanliness scores for previously unseen videos. The proposed model was evaluated on a dataset of 52 capsule endoscopy videos. Agreement with physicians was measured using Cohen’s kappa statistic. (3) Results: The system achieved a Cohen’s kappa agreement of 0.586 with physicians, which is notably higher than the intra-observer variability observed, measured at 0.546. Additionally, the system can show the cleanliness evolution throughout the entire video, helping justify the proposed score. (4) Conclusions: The proposed system demonstrates improved agreement with physicians compared to inter-physician agreement, showing its potential to support the cleanliness evaluation process in colon capsule endoscopy. The ability to visualize the cleanliness evolution across the video enhances the transparency and interpretability of the suggested score.

Accurate evaluation of capsule endoscopy videos plays a crucial role in diagnosing gastrointestinal disorders. One important aspect is the assessment of the cleansing quality, which indicates the visibility of the gastrointestinal mucosa during the examination. In this study, we propose a novel method for assigning a cleansing score to capsule endoscopy videos. Moreover, our system proposes a segmentation masks for each frame, highlighting the regions of the image that are not visible. This additional information aids in the interpretation and analysis of the videos, enabling more accurate diagnoses and improved patient care.