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Dr. Lei Fan
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2Years (2025-Present)
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Journal Article
LFLei Fan
Lei FanYLYuqing Lei
Yuqing LeiZQZhihui Qi
Zhihui QiHZHaiyang Zhang
Haiyang ZhangLTLin Tian
Lin TianFTFang Tang
Fang TangFumonisins, a major class of mycotoxins, pose significant health risks to humans and animals due to their widespread contamination and potent toxicity. Recent advances in molecular biology, biochemistry, and enzymology have greatly enhanced the understanding of fumonisin biosynthesis and its genetic regulation. The key biosynthetic genes are typically organized in clusters and regulated by specific transcription factors; increasing evidence also highlights the involvement of complex transcriptional and epigenetic mechanisms. Environmental factors such as nitrogen, carbon, and pH also modulate these regulatory networks. Despite substantial progress, critical gaps remain in fully elucidating the regulatory pathways that control fumonisin production. This review synthesizes current knowledge regarding fumonisin biosynthesis, gene clusters, and multi-level regulatory mechanisms, while emphasizing recent trends, existing challenges, and potential applications in food safety and biotechnology to enhance food security and promote sustainable development.
About Me
Lei Fan2024–Present Assistant Researcher, Academy of National Food and Strategic Reserves Administration Research focuses on the regulatory mechanisms of mycotoxin production by stored-grain fungi and strategies for mycotoxin prevention. Secured funding as Principal Investigator from the National Natural Science Foundation of China (Youth Program, No. 32502569) and the Fundamental Research Funds for the Central Research Institutes of China (No. ZX2505) in 2025. 2023–2024 Assistant Researcher, Changping Laboratory, Group of Academician Xiaoliang Sunney Xie Worked on the development of spatial ATAC-seq technology and gene research based on the Lianti-DBit platform within the Frontier Technology Platform. 2015–2020 Ph.D. in Genetics, Institute of Genetics and Developmental Biology, University of the Chinese Academy of Sciences (UCAS)Conducted research in Prof. Zhixi Tian’s group on functional mechanisms of genes associated with key agronomic traits in soybean. 2020–2022 Postdoctoral Researcher, Institute of Genetics and Developmental Biology, UCAS Continued soybean gene-function studies, particularly on the regulation of major agronomic traits. Contributed to a National Natural Science Foundation of China General Program (No. 32272107)and published research articles in Plant Biotechnology Journal, Molecular Plant, Journal of Integrative Plant Biology, and Nature Communications.