The histopathological effects of duodenogastric reflux (DGR) in children remain poorly described. This study aimed to evaluate and compare the gastric histopathological findings of pediatric patients with endoscopically confirmed DGR gastritis and those without, to identify potential morphological changes associated with bile reflux in childhood. This retrospective study compared children with endoscopically confirmed DGR to age- and sex-matched controls without DGR. Gastric biopsy samples were re-evaluated by a single pathologist blinded to clinical data. Histopathological features, including inflammation severity, activity, fibrosis, vascular congestion, edema, foveolar hyperplasia, the presence of Helicobacter pylori, lymphoid aggregates, reactive gastropathy, intestinal metaplasia, and glandular atrophy were compared. Logistic regression was used to identify significant predictors of DGR. A total of 73 patients with DGR and 65 controls were included. Fibrosis (60.2% vs. 9.2%, p < 0.001), congestion (63.0% vs. 27.7%, p < 0.001), foveolar hyperplasia (32.9% vs. 6.2%, p < 0.001), and edema (24.7% vs. 6.2%, p = 0.003) were significantly more common in the DGR group. Logistic regression identified foveolar hyperplasia (OR 10.67), edema (OR 9.01), fibrosis (OR 6.98), and congestion (OR 5.85) as independent predictors of DGR. Conclusion: Fibrosis, congestion, foveolar hyperplasia, and edema are significantly associated with DGR in pediatric patients and may serve as supportive histological markers for diagnosis. What is Known:• DGR in children lacks a standardized diagnostic method, with endoscopy and histopathology being commonly used.• Histopathological features such as foveolar hyperplasia and fibrosis are known in adults but less studied in children. What is New:• This study identifies fibrosis, congestion, foveolar hyperplasia, and edema as significant histopathological markers in pediatric DGR.• It suggests that endoscopic findings, combined with histopathology, can aid in the diagnosis of DGR in children.

Purpose: Demodex is a parasite that lives in the hair follicles or sebaceous glands of the eyelid. There are two species that live in humans. These are Demodex follicularum and Demodex brevis. Demodex mites have been found to be associated with many inflammatory diseases such as blepharitis, chalazion, and rosacea. The role of the inflammatory environment in the pathogenesis of cancer development is also known. Our aim in this study was to investigate the role of Demodex mites and inflammation in eyelid tumors. Materials and methods: Basal cell carcinoma, squamous cell carcinoma, and tumor-free control tissues were included in our study. In these cases, the presence and number of Demodex and the presence and severity of inflammation were evaluated. In addition, the demographic characteristics of the tumors and prognostic data such as tumor size and invasion depth were evaluated. Results: No significant difference was found between the tumor and control groups in terms of the presence of Demodex. However, a significant relationship was found between the inflammation caused by Demodex mites in basal cell carcinomas and tumor size and invasion depth. Conclusion: Demodex mites may create an inflammatory tumor environment and play a role in tumor growth and progression.

En tr Lipomas of the uterus are very rare tumors, they are often misdiagnosed by preoperative radiological examination due to their content and their rarity. Although MRI is preferred because of the fat nature of the lesion, the definitive diagnosis requires histopathological examination. Although many theories have been proposed about the histogenesis of the tumor, there is still no accepted theory. These lesions may have concomitant malignancy in the uterus, ovaries, and fallopian tubes, or may have other metabolic disorders and abnormal estrogen status. Here, we report a 39-year-old female patient who was admitted to the hospital with pelvic pain and irregular vaginal bleeding. Abdominal hysterectomy and bilateral salpingo-oopherectomy was performed and histopathological examination revealed rare occurrence of coexistent uterine lipoma, leiomyoma and endometrial polyp. Uterusun lipomları çok nadir görülen tümörler olup, preoperatif radyolojik incelemeleri ile içerikleri ve nadirlikleri nedeniyle sıklıkla yanlış tanı alırlar. Her ne kadar MRG lezyonun yağ yapısından dolayı tercih edilse de kesin tanı histopatolojik inceleme gerektirir. Tümörün histogenezi hakkında birçok teori öne sürülmüş olsa da, hala kabul edilmiş bir teori yoktur. Bu lezyonlar rahim, yumurtalıklar ve fallop tüplerinde eşlik eden maligniteye sahip olabilir veya başka metabolik bozukluklara ve anormal östrojen durumuna sahip olabilir. Burada, pelvik ağrı ve düzensiz vajinal kanama ile hastaneye başvuran 39 yaşında bir kadın hastayı sunuyoruz. Abdominal histerektomi ve bilateral salpingo-ooferektomi yapılmış ve histopatolojik incelemede nadir görülen uterin lipom, leiomyom ve endometrial polip birlikteliği saptanmıştır.