Image registration constitutes the fundamental basis for the joint interpretation of synthetic aperture radar (SAR) and optical images. However, robust image registration remains challenging due to significant regional heterogeneity in remote sensing scenes (e.g., co-existing urban and marine areas within a single image). To overcome this challenge, this article proposes a novel optical–SAR image registration method named Gradient and Standard Deviation Feature Weighted Fusion (GDWF). First, a Block-local standard deviation (Block-LSD) operator is proposed to extract block-based feature points with regional adaptability. Subsequently, a dual-modal feature description is developed, constructing both gradient-based descriptors and local standard deviation (LSD) descriptors for the neighborhoods surrounding the detected feature points. To further enhance matching robustness, a confidence-weighted feature fusion strategy is proposed. By establishing a reliability evaluation model for similarity measurement maps, the contribution weights of gradient features and LSD features are dynamically optimized, ensuring adaptive performance under varying conditions. To verify the effectiveness of the method, different optical and SAR datasets are used to compare it with the currently advanced algorithms MOGF, CFOG, and FED-HOPC. The experimental results demonstrate that the proposed GDWF algorithm achieves the best performance in terms of registration accuracy and robustness among all compared methods, effectively handling optical–SAR image pairs with significant regional heterogeneity.