Introduction: The presence of excessive noise poses a significant risk to the overall well-being and health of individuals. The presence of elevated noise levels within Intensive Care Units (ICUs) has the potential to exert detrimental effects on both the well-being of patients and the healthcare personnel. The aim of this study: This study aims to gather knowledge about the effects of noise pollution on patient’s wellbeing within Intensive Care Units, analyze various investigations around the world and discuss the possible preventive methods of reducing noise and thus sleep disturbances. Materials and methods: This review was based on available data collected in the PubMed database and Google Scholar web search engine using the key words Intensive Care Unit, sleep deprivation, noise pollution Conclusions: Intensive Care Unit noise disrupts patient’s sleep, communication, and increases stress, potentially leading to medical errors and longer recovery times. Addressing this issue is vital, aligning with patient-centered care and holistic therapy trends. Solutions include architectural changes, quieter equipment, staff education, clinical guidelines, and providing earplugs and eye masks for patient comfort. Noise negatively impacts sleep, causing circadian disruptions, cognitive impairments, and health issues. Identifying and mitigating noise sources can significantly enhance patient well-being and treatment outcomes.

Deviated septum, a common nasal structural abnormality, often leads to symptoms like nasal obstruction, sinusitis, and sleep disturbances, impacting respiratory function and quality of life. This clinical review emphasizes the critical role of septoplasty in the treatment of nasal septum deviation (NSD). While the nasal septum's anatomy is essential for proper airflow, deviations can cause significant issues, particularly in severe cases. Diagnosis involves clinical evaluation and imaging to assess the extent of deviation. Septoplasty, the gold standard treatment, realigns the septum to restore normal airflow and alleviate symptoms. The review also explores advances in septoplasty techniques aimed at improving outcomes and reducing recovery time. Overall, septoplasty remains the most effective intervention for managing NSD, with ongoing research focused on refining surgical methods and enhancing patient care.

Pancreatic cancer still has a 5-year survival rate in the single digits, making it one of the most aggressive and deadly cancers. The therapy of pancreatic cancer presents considerable hurdles because of its late diagnosis, fast development, and resistance to traditional therapies, even with advancements in oncological research. This study offers a thorough summary of the various treatment options available today, including as radiation therapy, chemotherapy, surgery, and the newly recognized roles of immunotherapy and targeted medicines. We examine the most recent advancements in personalized medicine and molecular profiling, which are starting to challenge established therapy paradigms and provide fresh hope for bettering patient outcomes. The study also outlines ongoing clinical trials that attempt to address the shortcomings of current therapy, such as the toxicity and limited efficacy of chemotherapeutic drugs. This study aims to provide a comprehensive overview of the pancreatic cancer therapy landscape by analyzing both conventional and cutting-edge treatments. It also identifies promising directions for future research and clinical practice.

Rotator cuff injuries are a prevalent and debilitating condition among athletes, particularly those engaged in overhead and throwing sports. Once primarily associated with aging populations, these injuries are now frequently diagnosed in younger, high-performance athletes due to advances in imaging and greater clinical awareness. This literature review synthesizes current knowledge on the etiology, diagnostic strategies, and modern treatment methods for rotator cuff injuries across various athletic disciplines. Key risk factors include repetitive microtrauma, poor biomechanics, scapular dyskinesis, and sport-specific demands such as the overhead motions in tennis, handball, and baseball. Diagnostic accuracy has significantly improved with the combined use of physical examination and imaging modalities - most notably MRI and ultrasonography. While MRI remains the gold standard for soft tissue visualization, ultrasound offers a cost-effective and dynamic alternative. Treatment options range from conservative management and rehabilitation to arthroscopic surgical repair, with outcomes influenced by age, sport, injury severity, and adherence to sport-specific rehabilitation protocols. Return-to-sport rates vary by population, with competitive athletes generally achieving faster recovery. The review underscores the need for tailored prevention, early diagnosis, and individualized rehabilitation strategies to optimize performance outcomes and long-term joint health in athletic populations.

Primary dysmenorrhea significantly impacts the daily functioning and well-being of adolescent girls and women of reproductive age. Although pharmacological treatment remains the standard approach, growing research highlights the effectiveness of non-pharmacological methods, particularly physical activity. This narrative review explores the role of exercise in alleviating menstrual pain, with an emphasis on its physiological mechanisms and the comparative effectiveness of various exercise types. We analyzed recent studies and meta-analyses focusing on aerobic activity, strength training, and relaxation-based techniques. The most promising outcomes were observed in structured exercise programs that included progressive muscle relaxation, abdominal massage, and resistance training, all of which consistently led to reduced pain intensity. Regular engagement in moderate aerobic exercise and yoga was also associated with significant symptom improvement after 8 to 12 weeks. In contrast, less structured or low-intensity activities such as Kegel exercises showed limited benefit unless sustained over a longer duration. Overall, physical activity appears to be a valuable complementary strategy in managing primary dysmenorrhea. When personalized and performed regularly, exercise interventions can offer meaningful symptom relief and potentially reduce reliance on medication. Further research is needed to refine exercise guidelines for this population.

The review article discusses the latest therapeutic approaches in the treatment of colorectal cancer (CRC), with a particular focus on metastatic disease. Despite advancements in standard treatments such as surgery, chemotherapy, and targeted therapies, the prognosis for patients with metastatic CRC remains poor, with five-year survival rates still low. The article examines the potential of immunotherapy, including PD-1 inhibitors like dostarlimab, which have shown promising results in treating selected patient groups. Additionally, the role of the ketogenic diet and probiotics as supportive strategies in CRC treatment is discussed, highlighting their potential to influence cancer metabolism and improve therapeutic outcomes. The article also addresses the development of nanotechnology-based therapies, such as PEGylated PLGA nanoparticles and sphingomyelin nanosystems, which may enhance drug delivery precision, thereby improving treatment efficacy and minimizing side effects. The conclusion emphasizes the need for further research into these innovative therapies and their integration with existing treatment protocols to improve survival and quality of life for CRC patients.