Amaranthus viridis L. belongs to family (Amaranthaceae) commonly known as “Chowlai” is a common wild vegetable and weed of cultivation. A. viridis contains several compounds like amino acids lysine, arginine, histidine, cystine, phenylalanine, leucine, isoleucine, valine, threonine, methionine, tyrosine etc. In search of new activities chemical entities, pytochemical screening of the extract from leaves of A. vilidis L. indicates the presence of biologically active constituent: saponins, tannins and phenols, flavonoids, alkaloids, cardiac glycoside, steroid and triterpenoids. A. vilidis L have some chemical constituent that exhibits potent anti-inflammatory, antihepatotoxic, antiulcer antiallergic, antiviral actions. A. viridis used in Indian and Nepalese traditional system to reduce labour pain and act an antipyretic. The Negritos of the Philippines apply the bruised leaves directly to eczema, psoriasis and rashes etc. Other traditional uses range from an anti-inflammatory agent of the urinary tract, venereal diseases vermifuge, diuretic, anti-rheumatic, antiulcer, analgesic, antiemetic, laxative, improvement of appetite, antilep-rotic, treatment of respiratory and eye problems , to treatment of asthma.

Colocasia esculenta (L) Schott of the family Araceae is an herbaceous perennial plant cultivated as annuals. Local name of C. esculenta is Kochu in Bangladesh and Taro in India. C. esculenta (L) is an ancient crop grown throughout the humid tropics and is widely used throughout the world; Africa, Asia, the West Indies, and South America. Its edible corms and leaves are traditionally used for hepatic ailments. Juice obtained from stems. Schott is used to stop bleeding from cuts and Wounds. The young leaves and roots are rich in Vitamin C as well as starch. It contains calcium, phosphorours, thiamine, riboflavin, niacin, oxalic acid, calcium oxalate, sapotoxin and flavones, apigenin and luteolin. The biological properties as well as chemical constituents of plant C. esculenta were widely used in folk medicine. In traditional medicine, C. esculenta is used as Anti microbial, Antihepatotoxic, Anti-cancer, Anti-Lipidperoxidative, Antibacterial and Antifungal, Antidiabetic, Anti-melanogenic, Anthelmintic. In present study, C. esculenta shows potent pharmacological activity such as Antimicrobial, Antihepatotoxic, Anti-cancer, Anti-Lipidperoxidative, antibacterial and Antifungal, Antidiabetic, Anti-melanogenic, Anthelmintic. Due to present of several potential chemical constituents it may use in several disease conditions for the future treatment.

A hyperactive tumour microenvironment (TME) drives unrestricted cancer cell survival, drug resistance, and metastasis in ovarian carcinoma (OC). However, therapeutic targets within the TME for OC remain elusive, and efficient methods to quantify TME activity are still limited. Herein, we employed an integrated bioinformatics approach to determine which immune-related genes (IRGs) modulate the TME and further assess their potential theragnostic (therapeutic + diagnostic) significance in OC progression. Using a robust approach, we developed a predictive risk model to retrospectively examine the clinicopathological parameters of OC patients from The Cancer Genome Atlas (TCGA) database. The validity of the prognostic model was confirmed with data from the International Cancer Genome Consortium (ICGC) cohort. Our approach identified nine IRGs, AKT2, FGF7, FOS, IL27RA, LRP1, OBP2A, PAEP, PDGFRA, and PI3, that form a prognostic model in OC progression, distinguishing patients with significantly better clinical outcomes in the low-risk group. We validated this model as an independent prognostic indicator and demonstrated enhanced prognostic significance when used alongside clinical nomograms for accurate prediction. Elevated LRP1 expression, which indicates poor prognosis in bladder cancer (BLCA), OC, low-grade gliomas (LGG), and glioblastoma (GBM), was also associated with immune infiltration in several other cancers. Significant correlations with immune checkpoint genes (ICGs) highlight the potential importance of LRP1 as a biomarker and therapeutic target. Furthermore, gene set enrichment analysis highlighted LRP1’s involvement in metabolism-related pathways, supporting its prognostic and therapeutic relevance also in BLCA, OC, low-grade gliomas (LGG), GBM, kidney cancer, OC, BLCA, kidney renal clear cell carcinoma (KIRC), stomach adenocarcinoma (STAD), and stomach and oesophageal carcinoma (STES). Our study has generated a novel signature of nine IRGs within the TME across cancers, that could serve as potential prognostic predictors and provide a valuable resource to improve the prognosis of OC.